Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 375-379 |
| Number of pages | 5 |
| Journal | Behavioural Brain Research |
| Volume | 222 |
| Issue number | 2 |
| Early online date | 12 Apr 2011 |
| DOIs | |
| Publication status | Published - 23 Sep 2011 |
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Keywords
- aged
- Alzheimer disease
- basal ganglia
- cerebrovascular circulation
- clinical trials, phase II as topic
- female
- frontal lobe
- humans
- male
- motor activity
- radiopharmaceuticals
- technetium Tc 99m exametazime
- tomography, emission-computed, single-photon
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Regional cerebral blood flow and aberrant motor behaviour in Alzheimer's disease. / Reilly, Thomas J; Staff, Roger T; Ahearn, Trevor S; Bentham, Peter; Wischik, Claude M; Murray, Alison D.
In: Behavioural Brain Research, Vol. 222, No. 2, 23.09.2011, p. 375-379.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regional cerebral blood flow and aberrant motor behaviour in Alzheimer's disease
AU - Reilly, Thomas J
AU - Staff, Roger T
AU - Ahearn, Trevor S
AU - Bentham, Peter
AU - Wischik, Claude M
AU - Murray, Alison D
N1 - Copyright © 2011 Elsevier B.V. All rights reserved.
PY - 2011/9/23
Y1 - 2011/9/23
N2 - Aberrant motor behaviour (AMB) in Alzheimer's disease shares behavioural correlates with obsessive compulsive disorder (OCD). We investigated whether AMB was also comparable in terms of metabolic activity in the orbitofrontal cortex (OFC), an area shown to be hyperactive in OCD. In this study 135 patients meeting research criteria for Alzheimer's disease were identified from a database of patients recruited as part of a phase II drug trial. These patients were assessed using the Neuropsychiatric Inventory, the Alzheimer's disease assessment scale, cognitive subscale and perfusion SPECT performed with 99Tc(m) hexamethylpropyleneamine oxime. Regions of interest were created for orbitofrontal cortices and basal ganglia. In 35 patients with AMB, adjusted tracer uptake was greater in the OFC. This reached statistical significance in right superior, left superior, right medial and left medial orbital gyri (p <0.05). The association between AMB and hyperactivity in the OFC remained significant after adjusting for the presence of anxiety. These results parallel the OFC hypermetabolism consistently seen in OCD. One model of OCD, proposes that dysfunctional interactions between frontal regions, including the OFC, produce the characteristic symptoms of OCD. The behaviour is though to be brought about by a perceived incompleteness of performing a task and is caused by an error in normal reward signals initiated upon task completion. These finding indicate that AMB in Alzheimer's disease are brought about by the same mechanistic failure.
AB - Aberrant motor behaviour (AMB) in Alzheimer's disease shares behavioural correlates with obsessive compulsive disorder (OCD). We investigated whether AMB was also comparable in terms of metabolic activity in the orbitofrontal cortex (OFC), an area shown to be hyperactive in OCD. In this study 135 patients meeting research criteria for Alzheimer's disease were identified from a database of patients recruited as part of a phase II drug trial. These patients were assessed using the Neuropsychiatric Inventory, the Alzheimer's disease assessment scale, cognitive subscale and perfusion SPECT performed with 99Tc(m) hexamethylpropyleneamine oxime. Regions of interest were created for orbitofrontal cortices and basal ganglia. In 35 patients with AMB, adjusted tracer uptake was greater in the OFC. This reached statistical significance in right superior, left superior, right medial and left medial orbital gyri (p <0.05). The association between AMB and hyperactivity in the OFC remained significant after adjusting for the presence of anxiety. These results parallel the OFC hypermetabolism consistently seen in OCD. One model of OCD, proposes that dysfunctional interactions between frontal regions, including the OFC, produce the characteristic symptoms of OCD. The behaviour is though to be brought about by a perceived incompleteness of performing a task and is caused by an error in normal reward signals initiated upon task completion. These finding indicate that AMB in Alzheimer's disease are brought about by the same mechanistic failure.
KW - aged
KW - Alzheimer disease
KW - basal ganglia
KW - cerebrovascular circulation
KW - clinical trials, phase II as topic
KW - female
KW - frontal lobe
KW - humans
KW - male
KW - motor activity
KW - radiopharmaceuticals
KW - technetium Tc 99m exametazime
KW - tomography, emission-computed, single-photon
U2 - 10.1016/j.bbr.2011.04.003
DO - 10.1016/j.bbr.2011.04.003
M3 - Article
VL - 222
SP - 375
EP - 379
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
IS - 2
ER -