Regional Differences in COVID-19 Vaccine Hesitancy in December 2020: A Natural Experiment in the French Working-Age Population

Fanny Velardo, Verity Watson, Pierre Arwidson, François Alla, Stéphane Luchini, Michaël Schwarzinger, CoVaMax Study Group

Research output: Contribution to journalArticlepeer-review

Abstract

It can be assumed that higher SARS-CoV-2 infection risk is associated with higher COVID-19 vaccination intentions, although evidence is scarce. In this large and representative survey of 6007 adults aged 18–64 years and residing in France, 8.1% (95% CI, 7.5–8.8) reported a prior SARS-CoV-2 infection in December 2020, with regional variations according to an East–West gradient (p < 0.0001). In participants without prior SARS-CoV-2 infection, COVID-19 vaccine hesitancy was substantial, including 41.3% (95% CI, 39.8–42.8) outright refusal of COVID-19 vaccination. Taking into account five characteristics of the first approved vaccines (efficacy, duration of immunity, safety, country of the vaccine manufacturer, and place of administration) as well as the initial setting of the mass vaccination campaign in France, COVID-19 vaccine acceptance would reach 43.6% (95% CI, 43.0–44.1) at best among working-age adults without prior SARS-CoV-2 infection. COVID-19 vaccine acceptance was primarily driven by vaccine characteristics, sociodemographic and attitudinal factors. Considering the region of residency as a proxy of the likelihood of getting infected, our study findings do not support the assumption that SARS-CoV-2 infection risk is associated with COVID-19 vaccine acceptance.
Original languageEnglish
Article number1364
Number of pages13
JournalVaccines
Volume9
Issue number11
Early online date20 Nov 2021
DOIs
Publication statusPublished - 20 Nov 2021

Keywords

  • SARS-CoV-2
  • COVID-19
  • mass vaccination
  • anti-vaccinations behavior
  • vaccine hesitancy
  • survey experiment
  • discrete choice experiment
  • France

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