Regulation and trafficking of muscarinic acetylcholine receptors

Dmitry Zenko, James N Hislop (Corresponding Author)

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Fidelity of signal transduction relies on cells expressing the appropriate number of functional receptors. Fluctuation in the total number of muscarinic acetylcholine receptors has been implicated in a range of physiological and pathophysiological processes, and the mechanisms responsible for this regulation represent potential molecular targets for therapeutic intervention. This article will review the current literature on the endocytic trafficking of muscarinic receptors and how knowledge of the trafficking of related receptors might influence future studies.

Original languageEnglish
Pages (from-to)374-382
Number of pages9
JournalNeuropharmacology
Volume136
Issue numberPart C
Early online date11 Nov 2017
DOIs
Publication statusPublished - 30 Jul 2018

Keywords

  • Journal Article
  • Review
  • Receptor
  • Trafficking
  • Recycling
  • Endocytosis
  • Down-Regulation

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