Regulation of genes encoding proteolytic enzymes during mammary gland development

D A Sorrell, M Szymanowska, M Boutinaud, C Robinson, R W E Clarkson, T Stein, D J Flint, Andreas Kolb

    Research output: Contribution to journalArticle

    15 Citations (Scopus)

    Abstract

    The mammary gland undergoes extensive tissue remodelling during each lactation cycle. During pregnancy, the epithelial compartment of the gland is vastly expanded (Benaud et al. 1998). At the end of lactation the epithelial cells undergo apoptosis and adipocyte differentiation is induced (Lilla et al. 2002). Ductal and alveolar growth during puberty and pregnancy, and the involution process require the action of proteolytic enzymes (including matrix metalloproteinases, plasminogen and membrane-peptidases) and the corresponding genes are activated during these periods (Benaud et al. 1998; Alexander et al. 2001). Matrix metalloproteinases (MMP) are expressed in several cell types of the mammary gland including stromal fibroblasts (e.g., MMP3, MMP2), epithelial cells (e.g., MMP7 or MMP9), adipocytes (e.g., MMP2) and lymphoid cells (e.g., MMP9) (Crawford et al. 1996; Lund et al. 1996; Wiseman et al. 2003). A number of knock-out mice, which are deficient for individual MMP genes (e.g., MMP2, MMP3) or plasminogen, display alterations to mammary gland structure and impairment of lactation (Lund et al. 1999; Wiseman et al. 2003).

    Original languageEnglish
    Pages (from-to)433-441
    Number of pages9
    JournalJournal of Dairy Research
    Volume72
    Issue number4
    Early online date14 Jul 2005
    DOIs
    Publication statusPublished - Nov 2005

    Keywords

    • matrix metalloproteinase
    • micro-array
    • quantitative PCR
    • pregnancy
    • involution
    • hepatocyte growth-factor
    • ETS transcription factors
    • matrix metalloproteinases
    • epithelial-cells
    • plasminogen-activator
    • binding protein
    • transgenic mice
    • factor receptor
    • apoptosis

    Cite this

    Sorrell, D. A., Szymanowska, M., Boutinaud, M., Robinson, C., Clarkson, R. W. E., Stein, T., ... Kolb, A. (2005). Regulation of genes encoding proteolytic enzymes during mammary gland development. Journal of Dairy Research, 72(4), 433-441. https://doi.org/10.1017/S0022029905001202

    Regulation of genes encoding proteolytic enzymes during mammary gland development. / Sorrell, D A ; Szymanowska, M ; Boutinaud, M ; Robinson, C ; Clarkson, R W E ; Stein, T ; Flint, D J ; Kolb, Andreas.

    In: Journal of Dairy Research, Vol. 72, No. 4, 11.2005, p. 433-441.

    Research output: Contribution to journalArticle

    Sorrell, DA, Szymanowska, M, Boutinaud, M, Robinson, C, Clarkson, RWE, Stein, T, Flint, DJ & Kolb, A 2005, 'Regulation of genes encoding proteolytic enzymes during mammary gland development', Journal of Dairy Research, vol. 72, no. 4, pp. 433-441. https://doi.org/10.1017/S0022029905001202
    Sorrell DA, Szymanowska M, Boutinaud M, Robinson C, Clarkson RWE, Stein T et al. Regulation of genes encoding proteolytic enzymes during mammary gland development. Journal of Dairy Research. 2005 Nov;72(4):433-441. https://doi.org/10.1017/S0022029905001202
    Sorrell, D A ; Szymanowska, M ; Boutinaud, M ; Robinson, C ; Clarkson, R W E ; Stein, T ; Flint, D J ; Kolb, Andreas. / Regulation of genes encoding proteolytic enzymes during mammary gland development. In: Journal of Dairy Research. 2005 ; Vol. 72, No. 4. pp. 433-441.
    @article{e59612c790fc4522b649f99ca7e90e6d,
    title = "Regulation of genes encoding proteolytic enzymes during mammary gland development",
    abstract = "The mammary gland undergoes extensive tissue remodelling during each lactation cycle. During pregnancy, the epithelial compartment of the gland is vastly expanded (Benaud et al. 1998). At the end of lactation the epithelial cells undergo apoptosis and adipocyte differentiation is induced (Lilla et al. 2002). Ductal and alveolar growth during puberty and pregnancy, and the involution process require the action of proteolytic enzymes (including matrix metalloproteinases, plasminogen and membrane-peptidases) and the corresponding genes are activated during these periods (Benaud et al. 1998; Alexander et al. 2001). Matrix metalloproteinases (MMP) are expressed in several cell types of the mammary gland including stromal fibroblasts (e.g., MMP3, MMP2), epithelial cells (e.g., MMP7 or MMP9), adipocytes (e.g., MMP2) and lymphoid cells (e.g., MMP9) (Crawford et al. 1996; Lund et al. 1996; Wiseman et al. 2003). A number of knock-out mice, which are deficient for individual MMP genes (e.g., MMP2, MMP3) or plasminogen, display alterations to mammary gland structure and impairment of lactation (Lund et al. 1999; Wiseman et al. 2003).",
    keywords = "matrix metalloproteinase, micro-array, quantitative PCR, pregnancy, involution, hepatocyte growth-factor, ETS transcription factors, matrix metalloproteinases, epithelial-cells, plasminogen-activator, binding protein, transgenic mice, factor receptor, apoptosis",
    author = "Sorrell, {D A} and M Szymanowska and M Boutinaud and C Robinson and Clarkson, {R W E} and T Stein and Flint, {D J} and Andreas Kolb",
    year = "2005",
    month = "11",
    doi = "10.1017/S0022029905001202",
    language = "English",
    volume = "72",
    pages = "433--441",
    journal = "Journal of Dairy Research",
    issn = "0022-0299",
    publisher = "Cambridge University Press",
    number = "4",

    }

    TY - JOUR

    T1 - Regulation of genes encoding proteolytic enzymes during mammary gland development

    AU - Sorrell, D A

    AU - Szymanowska, M

    AU - Boutinaud, M

    AU - Robinson, C

    AU - Clarkson, R W E

    AU - Stein, T

    AU - Flint, D J

    AU - Kolb, Andreas

    PY - 2005/11

    Y1 - 2005/11

    N2 - The mammary gland undergoes extensive tissue remodelling during each lactation cycle. During pregnancy, the epithelial compartment of the gland is vastly expanded (Benaud et al. 1998). At the end of lactation the epithelial cells undergo apoptosis and adipocyte differentiation is induced (Lilla et al. 2002). Ductal and alveolar growth during puberty and pregnancy, and the involution process require the action of proteolytic enzymes (including matrix metalloproteinases, plasminogen and membrane-peptidases) and the corresponding genes are activated during these periods (Benaud et al. 1998; Alexander et al. 2001). Matrix metalloproteinases (MMP) are expressed in several cell types of the mammary gland including stromal fibroblasts (e.g., MMP3, MMP2), epithelial cells (e.g., MMP7 or MMP9), adipocytes (e.g., MMP2) and lymphoid cells (e.g., MMP9) (Crawford et al. 1996; Lund et al. 1996; Wiseman et al. 2003). A number of knock-out mice, which are deficient for individual MMP genes (e.g., MMP2, MMP3) or plasminogen, display alterations to mammary gland structure and impairment of lactation (Lund et al. 1999; Wiseman et al. 2003).

    AB - The mammary gland undergoes extensive tissue remodelling during each lactation cycle. During pregnancy, the epithelial compartment of the gland is vastly expanded (Benaud et al. 1998). At the end of lactation the epithelial cells undergo apoptosis and adipocyte differentiation is induced (Lilla et al. 2002). Ductal and alveolar growth during puberty and pregnancy, and the involution process require the action of proteolytic enzymes (including matrix metalloproteinases, plasminogen and membrane-peptidases) and the corresponding genes are activated during these periods (Benaud et al. 1998; Alexander et al. 2001). Matrix metalloproteinases (MMP) are expressed in several cell types of the mammary gland including stromal fibroblasts (e.g., MMP3, MMP2), epithelial cells (e.g., MMP7 or MMP9), adipocytes (e.g., MMP2) and lymphoid cells (e.g., MMP9) (Crawford et al. 1996; Lund et al. 1996; Wiseman et al. 2003). A number of knock-out mice, which are deficient for individual MMP genes (e.g., MMP2, MMP3) or plasminogen, display alterations to mammary gland structure and impairment of lactation (Lund et al. 1999; Wiseman et al. 2003).

    KW - matrix metalloproteinase

    KW - micro-array

    KW - quantitative PCR

    KW - pregnancy

    KW - involution

    KW - hepatocyte growth-factor

    KW - ETS transcription factors

    KW - matrix metalloproteinases

    KW - epithelial-cells

    KW - plasminogen-activator

    KW - binding protein

    KW - transgenic mice

    KW - factor receptor

    KW - apoptosis

    U2 - 10.1017/S0022029905001202

    DO - 10.1017/S0022029905001202

    M3 - Article

    VL - 72

    SP - 433

    EP - 441

    JO - Journal of Dairy Research

    JF - Journal of Dairy Research

    SN - 0022-0299

    IS - 4

    ER -