Regulation of leptin receptor and NPY gene expression in hypothalamus of leptin-treated obese (ob/ob) and cold-exposed lean mice

Julian Mercer, Kim-Marie Moar, D V Rayner, P Trayhurn, Nigel Hoggard

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

Leptin receptor gene expression has been measured in arcuate and ventromedial hypothalamic nuclei. Receptor mRNA in both hypothalamic areas was higher in obese mice than in lean littermates. Twice daily leptin administration for 7 days profoundly affected food intake, reduced leptin receptor mRNA in the arcuate nucleus, and had a similar effect on neuropeptide Y gene expression. A single leptin injection was ineffective. Exposure of lean mice to cold for 24 h caused an induction of leptin receptor and NPY mRNA which was normalized when animals were returned to the warm. Regulation of receptor gene expression may be an important component in the reading of the leptin signal.
Original languageEnglish
Pages (from-to)185-188
Number of pages4
JournalFEBS Letters
Volume402
Issue number2-3
DOIs
Publication statusPublished - 3 Feb 1997

Fingerprint

Leptin Receptors
Leptin
Gene expression
Hypothalamus
Gene Expression
Messenger RNA
Ventromedial Hypothalamic Nucleus
Obese Mice
Arcuate Nucleus of Hypothalamus
Neuropeptide Y
Gene Expression Regulation
Reading
Animals
Eating
Injections

Keywords

  • Acclimatization
  • Analysis of Variance
  • Animals
  • Arcuate Nucleus
  • Carrier Proteins
  • Cold Temperature
  • Feeding Behavior
  • Gene Expression Regulation
  • Hypothalamus
  • In Situ Hybridization
  • Leptin
  • Mice
  • Mice, Obese
  • Obesity
  • Proteins
  • RNA, Messenger
  • Receptors, Cell Surface
  • Receptors, Leptin
  • Receptors, Neuropeptide Y
  • Recombinant Proteins
  • Transcription, Genetic
  • Ventromedial Hypothalamic Nucleus

Cite this

Regulation of leptin receptor and NPY gene expression in hypothalamus of leptin-treated obese (ob/ob) and cold-exposed lean mice. / Mercer, Julian; Moar, Kim-Marie; Rayner, D V; Trayhurn, P; Hoggard, Nigel.

In: FEBS Letters, Vol. 402, No. 2-3, 03.02.1997, p. 185-188.

Research output: Contribution to journalArticle

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AU - Hoggard, Nigel

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KW - Obesity

KW - Proteins

KW - RNA, Messenger

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KW - Receptors, Neuropeptide Y

KW - Recombinant Proteins

KW - Transcription, Genetic

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