Regulatory T cells secreting IL-10 dominate the immune response to EBV latent membrane protein 11

Neil Andrew Marshall, Mark Adrian Vickers, Robert Norman Barker

Research output: Contribution to journalArticle

Abstract

Viruses exploit a number of strategies to evade immune recognition. In this study, we describe a novel mechanism by which EBV, rather than avoiding detection, subverts the immune response by stimulating regulatory T cells that secrete IL-10. Human PBMC from all EBV-seropositive, but not -seronegative, donors responded to both purified latent membrane protein 1 and the corresponding immunodominant peptides with high levels of IL-10 secretion by CD4+ T cells. These IL-10 responses, characteristic of T regulatory I cells, inhibited T cell proliferation and IFN-gamma secretion induced by both mitogen and recall Ag. It was confirmed that the inhibition was IL-10 dependent by the use of neutralizing Ab. The deviation of the immune response toward suppression is likely to be important in maintaining latency and EBV-associated tumors.

Original languageEnglish
Pages (from-to)6183-6189
Number of pages6
JournalThe Journal of Immunology
Volume170
Issue number12
Publication statusPublished - Jun 2003

Keywords

  • BARR-VIRUS EBV
  • NF-KAPPA-B
  • T-REGULATORY-1 CELLS
  • CYTOKINE PRODUCTION
  • NUCLEAR ANTIGEN-1
  • EPITHELIAL-CELLS
  • HELPER TYPE-1
  • ENCODED LMP1
  • IN-VITRO
  • IDENTIFICATION

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