Relationship Between Cannabis Use and Erectile Dysfunction: A Systematic Review and Meta-Analysis

Damiano Pizzol*, Jacopo Demurtas, Brendon Stubbs, Pinar Soysal, Corina Mason, Ahmet Turan Isik, Marco Solmi, Lee Smith, Nicola Veronese

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Globally, there is increasing usage and legalization of cannabis. In addition to its reported therapeutic effects, cannabis has several health risks which are not clearly defined. Erectile dysfunction (ED) is the most common male sexual disorder and there are plausible mechanisms linking cannabis use to ED. No attempt has been made to collate the literature on this topic. The aim of this review was to summarize the prevalence and risk of ED in cannabis users compared to controls. A systematic review of major databases from inception to January 1, 2019, without language restriction, was undertaken to identify studies investigating cannabis use and presence of ED. The analysis compared the prevalence of ED in cannabis users versus controls. Consequently, the odds ratio (OR) with 95% confidence intervals (CI) was calculated, applying a random-effect model. Five case-control studies were included with data from 3,395 healthy men, 1,035 using cannabis (smoking) and 2,360 nonusers. The overall prevalence of ED in cannabis users was 69.1% (95% CI: 38.0-89.1), whilst the correspondent figure in controls was 34.7% (95% CI: 20.3-52.7). The OR of ED in cannabis users was almost four times that of controls (OR = 3.83; 95% CI: 1.30-11.28; p = .02), even if characterized by high heterogeneity (I2 = 90%) and the prediction intervals overlapped 1.00 (95% CI: 0.35-7.26). Data suggest that ED is twice as high in cannabis users compared to controls. Future longitudinal research is needed to confirm/refute this and explore if a dose-response relationship between cannabis and ED may be evident.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalAmerican Journal of Men's Health
Volume13
Issue number6
DOIs
Publication statusPublished - 1 Dec 2019

Fingerprint

Erectile Dysfunction
Cannabis
Meta-Analysis
confidence
Confidence Intervals
sexual disorder
Odds Ratio
legalization
health risk
Marijuana Smoking
smoking
Therapeutic Uses
Case-Control Studies
language
Language
Databases
Health

Keywords

  • Cannabis
  • erectile dysfunction
  • prevalence
  • meta-analysis
  • systematic review
  • MARIJUANA
  • QUALITY
  • BIAS
  • MEN
  • PENILE ERECTION
  • RISK
  • ASSOCIATION

ASJC Scopus subject areas

  • Health(social science)
  • Public Health, Environmental and Occupational Health

Cite this

Relationship Between Cannabis Use and Erectile Dysfunction : A Systematic Review and Meta-Analysis. / Pizzol, Damiano; Demurtas, Jacopo; Stubbs, Brendon; Soysal, Pinar; Mason, Corina; Isik, Ahmet Turan; Solmi, Marco; Smith, Lee; Veronese, Nicola.

In: American Journal of Men's Health, Vol. 13, No. 6, 01.12.2019, p. 1-7.

Research output: Contribution to journalArticle

Pizzol, D, Demurtas, J, Stubbs, B, Soysal, P, Mason, C, Isik, AT, Solmi, M, Smith, L & Veronese, N 2019, 'Relationship Between Cannabis Use and Erectile Dysfunction: A Systematic Review and Meta-Analysis', American Journal of Men's Health, vol. 13, no. 6, pp. 1-7. https://doi.org/10.1177/1557988319892464
Pizzol, Damiano ; Demurtas, Jacopo ; Stubbs, Brendon ; Soysal, Pinar ; Mason, Corina ; Isik, Ahmet Turan ; Solmi, Marco ; Smith, Lee ; Veronese, Nicola. / Relationship Between Cannabis Use and Erectile Dysfunction : A Systematic Review and Meta-Analysis. In: American Journal of Men's Health. 2019 ; Vol. 13, No. 6. pp. 1-7.
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N1 - Funding The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: BS is supported by the Health Education England and the National Institute for Health Research HEE/ NIHR ICA Programme Clinical Lectureship (ICA-CL-2017-03-001). The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the National Institute for Health Research, the Department of Health and Social Care or the Italian Agency for Development Cooperation.

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