Relationship between serum lipids and markers of bone health in post-menopausal women

Adrian David Wood, Antonia D Hardcastle, Garry Graeme Duthie, William D Fraser, David MacAulay Reid, Helen MacDonald

Research output: Contribution to journalAbstract

Abstract

CVD and osteoporosis are major chronic diseases that have a profound impact on morbidity and mortality in the UK. Epidemiological studies suggest that the two diseases are linked. Osteoblasts and adipocytes share a common progenitor in the bone marrow and it hasbeen hypothesised that an atherogenic lipid profile has a negative influence on bone formation. The aim of the present study was to testthe relationship between serum lipids and markers of bone health (bone mineral density (BMD) and bone-turnover markers) in post-menopausal women living in north east Scotland.A total of 272 women (mean age 59.6 (SD2.1) years) took part in an intervention trial investigating the mechanisms associated with theeffects of fruit and vegetable intake on bone health. Serum lipids were determined at 1 year for a subset of the women (placebo and fruitand vegetable arms). BMD was measured at the hip (mean of right and left hip) and lumbar spine (LS) by dual X-ray absorptiometry(Lunar Prodigy; GE Medical Systems Inc. Madison, WI, USA); the bone formation marker serum N-terminal propeptide of type 1collagen (P1NP) and the bone resportion marker serumbC-terminal telopeptide (CTX) were measured using enzyme chemiluminescentimmunoassays (Roche Diagnostics GmbH, Mannheim, Germany). Serum LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), TAG andtotal cholesterol were measured using a KONE clinical chemistry analyser (Thermo Fisher Scientific Inc., Waltham, MA, USA).There were no significant differences in serum lipid or BMD measurements between the placebo and fruit and vegetable group. Frombivariate correlations for the combined group (n119), significant negative associations were observed between LDL-C and BMD (LS andhip), remaining significant after adjustment for weight and height, whereas the negative association between HDL-C and mean hip BMDwas no longer significant after adjustment for these confounders (r values shown in Table). For the bone-turnover markers, HDL-C waspositively associated with P1NP at baseline and 1 year, remaining significant after adjustment for height and weight, whereas associationsbetween HDL-C and CTX were not significant after adjustment for confounders. Serum TAG were negatively associated with P1NP andCTX at 1 year only.

These results support findings relating serum lipids and BMD reported in other populations. The relationship between HDL-C andP1NP is consistent with the hypothesis that a healthy lipid profile is linked with bone formation. Further research is required to elucidatethe mechanisms behind these observations.
Original languageEnglish
Article numberOCE1
Pages (from-to)E123
JournalProceedings of the Nutrition Society
Volume69
Issue number1
DOIs
Publication statusPublished - 2010

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Bone Density
HDL Cholesterol
Biomarkers
Lipids
Bone and Bones
Health
Osteogenesis
Vegetables
Hip
Serum
Bone Remodeling
LDL Cholesterol
Fruit
Spine
Placebos
Weights and Measures
Clinical Chemistry
Photon Absorptiometry
Scotland
Osteoblasts

Cite this

Relationship between serum lipids and markers of bone health in post-menopausal women. / Wood, Adrian David; Hardcastle, Antonia D; Duthie, Garry Graeme; Fraser, William D; Reid, David MacAulay; MacDonald, Helen.

In: Proceedings of the Nutrition Society, Vol. 69, No. 1, OCE1, 2010, p. E123.

Research output: Contribution to journalAbstract

Wood, Adrian David ; Hardcastle, Antonia D ; Duthie, Garry Graeme ; Fraser, William D ; Reid, David MacAulay ; MacDonald, Helen. / Relationship between serum lipids and markers of bone health in post-menopausal women. In: Proceedings of the Nutrition Society. 2010 ; Vol. 69, No. 1. pp. E123.
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abstract = "CVD and osteoporosis are major chronic diseases that have a profound impact on morbidity and mortality in the UK. Epidemiological studies suggest that the two diseases are linked. Osteoblasts and adipocytes share a common progenitor in the bone marrow and it hasbeen hypothesised that an atherogenic lipid profile has a negative influence on bone formation. The aim of the present study was to testthe relationship between serum lipids and markers of bone health (bone mineral density (BMD) and bone-turnover markers) in post-menopausal women living in north east Scotland.A total of 272 women (mean age 59.6 (SD2.1) years) took part in an intervention trial investigating the mechanisms associated with theeffects of fruit and vegetable intake on bone health. Serum lipids were determined at 1 year for a subset of the women (placebo and fruitand vegetable arms). BMD was measured at the hip (mean of right and left hip) and lumbar spine (LS) by dual X-ray absorptiometry(Lunar Prodigy; GE Medical Systems Inc. Madison, WI, USA); the bone formation marker serum N-terminal propeptide of type 1collagen (P1NP) and the bone resportion marker serumbC-terminal telopeptide (CTX) were measured using enzyme chemiluminescentimmunoassays (Roche Diagnostics GmbH, Mannheim, Germany). Serum LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), TAG andtotal cholesterol were measured using a KONE clinical chemistry analyser (Thermo Fisher Scientific Inc., Waltham, MA, USA).There were no significant differences in serum lipid or BMD measurements between the placebo and fruit and vegetable group. Frombivariate correlations for the combined group (n119), significant negative associations were observed between LDL-C and BMD (LS andhip), remaining significant after adjustment for weight and height, whereas the negative association between HDL-C and mean hip BMDwas no longer significant after adjustment for these confounders (r values shown in Table). For the bone-turnover markers, HDL-C waspositively associated with P1NP at baseline and 1 year, remaining significant after adjustment for height and weight, whereas associationsbetween HDL-C and CTX were not significant after adjustment for confounders. Serum TAG were negatively associated with P1NP andCTX at 1 year only. These results support findings relating serum lipids and BMD reported in other populations. The relationship between HDL-C andP1NP is consistent with the hypothesis that a healthy lipid profile is linked with bone formation. Further research is required to elucidatethe mechanisms behind these observations.",
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T1 - Relationship between serum lipids and markers of bone health in post-menopausal women

AU - Wood, Adrian David

AU - Hardcastle, Antonia D

AU - Duthie, Garry Graeme

AU - Fraser, William D

AU - Reid, David MacAulay

AU - MacDonald, Helen

PY - 2010

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N2 - CVD and osteoporosis are major chronic diseases that have a profound impact on morbidity and mortality in the UK. Epidemiological studies suggest that the two diseases are linked. Osteoblasts and adipocytes share a common progenitor in the bone marrow and it hasbeen hypothesised that an atherogenic lipid profile has a negative influence on bone formation. The aim of the present study was to testthe relationship between serum lipids and markers of bone health (bone mineral density (BMD) and bone-turnover markers) in post-menopausal women living in north east Scotland.A total of 272 women (mean age 59.6 (SD2.1) years) took part in an intervention trial investigating the mechanisms associated with theeffects of fruit and vegetable intake on bone health. Serum lipids were determined at 1 year for a subset of the women (placebo and fruitand vegetable arms). BMD was measured at the hip (mean of right and left hip) and lumbar spine (LS) by dual X-ray absorptiometry(Lunar Prodigy; GE Medical Systems Inc. Madison, WI, USA); the bone formation marker serum N-terminal propeptide of type 1collagen (P1NP) and the bone resportion marker serumbC-terminal telopeptide (CTX) were measured using enzyme chemiluminescentimmunoassays (Roche Diagnostics GmbH, Mannheim, Germany). Serum LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), TAG andtotal cholesterol were measured using a KONE clinical chemistry analyser (Thermo Fisher Scientific Inc., Waltham, MA, USA).There were no significant differences in serum lipid or BMD measurements between the placebo and fruit and vegetable group. Frombivariate correlations for the combined group (n119), significant negative associations were observed between LDL-C and BMD (LS andhip), remaining significant after adjustment for weight and height, whereas the negative association between HDL-C and mean hip BMDwas no longer significant after adjustment for these confounders (r values shown in Table). For the bone-turnover markers, HDL-C waspositively associated with P1NP at baseline and 1 year, remaining significant after adjustment for height and weight, whereas associationsbetween HDL-C and CTX were not significant after adjustment for confounders. Serum TAG were negatively associated with P1NP andCTX at 1 year only. These results support findings relating serum lipids and BMD reported in other populations. The relationship between HDL-C andP1NP is consistent with the hypothesis that a healthy lipid profile is linked with bone formation. Further research is required to elucidatethe mechanisms behind these observations.

AB - CVD and osteoporosis are major chronic diseases that have a profound impact on morbidity and mortality in the UK. Epidemiological studies suggest that the two diseases are linked. Osteoblasts and adipocytes share a common progenitor in the bone marrow and it hasbeen hypothesised that an atherogenic lipid profile has a negative influence on bone formation. The aim of the present study was to testthe relationship between serum lipids and markers of bone health (bone mineral density (BMD) and bone-turnover markers) in post-menopausal women living in north east Scotland.A total of 272 women (mean age 59.6 (SD2.1) years) took part in an intervention trial investigating the mechanisms associated with theeffects of fruit and vegetable intake on bone health. Serum lipids were determined at 1 year for a subset of the women (placebo and fruitand vegetable arms). BMD was measured at the hip (mean of right and left hip) and lumbar spine (LS) by dual X-ray absorptiometry(Lunar Prodigy; GE Medical Systems Inc. Madison, WI, USA); the bone formation marker serum N-terminal propeptide of type 1collagen (P1NP) and the bone resportion marker serumbC-terminal telopeptide (CTX) were measured using enzyme chemiluminescentimmunoassays (Roche Diagnostics GmbH, Mannheim, Germany). Serum LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), TAG andtotal cholesterol were measured using a KONE clinical chemistry analyser (Thermo Fisher Scientific Inc., Waltham, MA, USA).There were no significant differences in serum lipid or BMD measurements between the placebo and fruit and vegetable group. Frombivariate correlations for the combined group (n119), significant negative associations were observed between LDL-C and BMD (LS andhip), remaining significant after adjustment for weight and height, whereas the negative association between HDL-C and mean hip BMDwas no longer significant after adjustment for these confounders (r values shown in Table). For the bone-turnover markers, HDL-C waspositively associated with P1NP at baseline and 1 year, remaining significant after adjustment for height and weight, whereas associationsbetween HDL-C and CTX were not significant after adjustment for confounders. Serum TAG were negatively associated with P1NP andCTX at 1 year only. These results support findings relating serum lipids and BMD reported in other populations. The relationship between HDL-C andP1NP is consistent with the hypothesis that a healthy lipid profile is linked with bone formation. Further research is required to elucidatethe mechanisms behind these observations.

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DO - 10.1017/S0029665109993119

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VL - 69

SP - E123

JO - Proceedings of the Nutrition Society

JF - Proceedings of the Nutrition Society

SN - 0029-6651

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M1 - OCE1

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