Relationships between resting metabolic rate and morphology in lactating mice

What tissues are the major contributors to resting metabolism?

John Roger Speakman, Lorna Mary Johnson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We sought the relationship between resting metabolic rate (RMR) and gross tissue morphology in 59 lactating female MFI mice. RMR was measured at peak lactation (Day 18 post partum) and the animals were then immediately killed and dissected into 18 separate components which were dried for 14 days at 60 degreesC. Individual variation in the RMR (CV) was 27%. The masses of the tissue components were similarly variable (CV ranging from 4.3% for the brain to around 150% for fat tissue). RMR was significantly related to overall body mass (r(2) = 0.458) with a scaling exponent of 1.55. Similar significant relationships were evident between masses of most (16/18) of the tissues and overall body mass. Accordingly there were significant relationships between RMR and all the tissue masses with the exception of those tissues poorly related to overall body mass (specifically the lungs, small intestine, brain and kidneys). When the shared variation due to total body mass was eliminated there were no significant links between residual RMR and residual In;lss of any tissue. Re-describing the morphology using principal components analysis revealed a link between a general size component (PC1) and RMR (r(2) = 0.374) but this relationship disappeared when residual RMR was employed as the dependent variable. Despite other studies that indicate wide variations in the rates at which different tissues metabolise energy ill vitro there was no indication in the present study that any particular component of the morphology was linked to high RMR in vivo.

Original languageEnglish
Title of host publicationLife in the Cold
Place of PublicationBerlin
PublisherSpringer-Verlag
Number of pages8
ISBN (Print)3-540-67410-1
Publication statusPublished - 2000

Keywords

  • energy budgets
  • daily torpor
  • intraspecific variation
  • mammals
  • hibernation
  • birds
  • reproduction
  • limits
  • mus

Cite this

Relationships between resting metabolic rate and morphology in lactating mice : What tissues are the major contributors to resting metabolism? / Speakman, John Roger; Johnson, Lorna Mary.

Life in the Cold. Berlin : Springer-Verlag, 2000.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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abstract = "We sought the relationship between resting metabolic rate (RMR) and gross tissue morphology in 59 lactating female MFI mice. RMR was measured at peak lactation (Day 18 post partum) and the animals were then immediately killed and dissected into 18 separate components which were dried for 14 days at 60 degreesC. Individual variation in the RMR (CV) was 27{\%}. The masses of the tissue components were similarly variable (CV ranging from 4.3{\%} for the brain to around 150{\%} for fat tissue). RMR was significantly related to overall body mass (r(2) = 0.458) with a scaling exponent of 1.55. Similar significant relationships were evident between masses of most (16/18) of the tissues and overall body mass. Accordingly there were significant relationships between RMR and all the tissue masses with the exception of those tissues poorly related to overall body mass (specifically the lungs, small intestine, brain and kidneys). When the shared variation due to total body mass was eliminated there were no significant links between residual RMR and residual In;lss of any tissue. Re-describing the morphology using principal components analysis revealed a link between a general size component (PC1) and RMR (r(2) = 0.374) but this relationship disappeared when residual RMR was employed as the dependent variable. Despite other studies that indicate wide variations in the rates at which different tissues metabolise energy ill vitro there was no indication in the present study that any particular component of the morphology was linked to high RMR in vivo.",
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N2 - We sought the relationship between resting metabolic rate (RMR) and gross tissue morphology in 59 lactating female MFI mice. RMR was measured at peak lactation (Day 18 post partum) and the animals were then immediately killed and dissected into 18 separate components which were dried for 14 days at 60 degreesC. Individual variation in the RMR (CV) was 27%. The masses of the tissue components were similarly variable (CV ranging from 4.3% for the brain to around 150% for fat tissue). RMR was significantly related to overall body mass (r(2) = 0.458) with a scaling exponent of 1.55. Similar significant relationships were evident between masses of most (16/18) of the tissues and overall body mass. Accordingly there were significant relationships between RMR and all the tissue masses with the exception of those tissues poorly related to overall body mass (specifically the lungs, small intestine, brain and kidneys). When the shared variation due to total body mass was eliminated there were no significant links between residual RMR and residual In;lss of any tissue. Re-describing the morphology using principal components analysis revealed a link between a general size component (PC1) and RMR (r(2) = 0.374) but this relationship disappeared when residual RMR was employed as the dependent variable. Despite other studies that indicate wide variations in the rates at which different tissues metabolise energy ill vitro there was no indication in the present study that any particular component of the morphology was linked to high RMR in vivo.

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