Reparative medicine: from tissue engineering to joint surface regeneration

Cosimo De Bari, Costantino Pitzalis, Francesco Dell'Accio

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Biological regeneration is proving to be an increasingly attractive alternative/complement to prosthetic replacement of tissues and organs. In cell-based therapeutic approaches, cells are manipulated in vitro and administered to patients as living and dynamic biological agents. In this review, we have focused on the regeneration of the injured joint surface to discuss novel issues that these new therapeutic agents raise and are difficult to address within the paradigms of traditional pharmacology. They include: determination of the mechanism of action and dose, evaluation of potency, safety and toxicity, as well as upscale, delivery and identification of proper indications. Finally, novel potential approaches are proposed in which resident progenitor cells are targeted to regenerate the damaged tissue.
Original languageEnglish
Pages (from-to)59-69
Number of pages11
JournalRegenerative Medicine
Volume1
Issue number1
DOIs
Publication statusPublished - 1 Jan 2006

Fingerprint

Tissue Engineering
Tissue engineering
Medicine
Regeneration
Joints
Tissue
Biological Factors
Prosthetics
Toxicity
Stem Cells
Pharmacology
Safety
Therapeutics
In Vitro Techniques

Keywords

  • Biocompatible Materials
  • Guided Tissue Regeneration
  • Humans
  • Joints
  • Models, Biological
  • Regenerative Medicine
  • Stem Cells
  • Tissue Engineering

Cite this

Reparative medicine : from tissue engineering to joint surface regeneration. / De Bari, Cosimo; Pitzalis, Costantino; Dell'Accio, Francesco.

In: Regenerative Medicine, Vol. 1, No. 1, 01.01.2006, p. 59-69.

Research output: Contribution to journalArticle

De Bari, Cosimo ; Pitzalis, Costantino ; Dell'Accio, Francesco. / Reparative medicine : from tissue engineering to joint surface regeneration. In: Regenerative Medicine. 2006 ; Vol. 1, No. 1. pp. 59-69.
@article{601b08511f15459d869ce9c48d604dec,
title = "Reparative medicine: from tissue engineering to joint surface regeneration",
abstract = "Biological regeneration is proving to be an increasingly attractive alternative/complement to prosthetic replacement of tissues and organs. In cell-based therapeutic approaches, cells are manipulated in vitro and administered to patients as living and dynamic biological agents. In this review, we have focused on the regeneration of the injured joint surface to discuss novel issues that these new therapeutic agents raise and are difficult to address within the paradigms of traditional pharmacology. They include: determination of the mechanism of action and dose, evaluation of potency, safety and toxicity, as well as upscale, delivery and identification of proper indications. Finally, novel potential approaches are proposed in which resident progenitor cells are targeted to regenerate the damaged tissue.",
keywords = "Biocompatible Materials, Guided Tissue Regeneration, Humans, Joints, Models, Biological, Regenerative Medicine, Stem Cells, Tissue Engineering",
author = "{De Bari}, Cosimo and Costantino Pitzalis and Francesco Dell'Accio",
year = "2006",
month = "1",
day = "1",
doi = "10.2217/17460751.1.1.59",
language = "English",
volume = "1",
pages = "59--69",
journal = "Regenerative Medicine",
issn = "1746-0751",
publisher = "Future Medicine Ltd.",
number = "1",

}

TY - JOUR

T1 - Reparative medicine

T2 - from tissue engineering to joint surface regeneration

AU - De Bari, Cosimo

AU - Pitzalis, Costantino

AU - Dell'Accio, Francesco

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Biological regeneration is proving to be an increasingly attractive alternative/complement to prosthetic replacement of tissues and organs. In cell-based therapeutic approaches, cells are manipulated in vitro and administered to patients as living and dynamic biological agents. In this review, we have focused on the regeneration of the injured joint surface to discuss novel issues that these new therapeutic agents raise and are difficult to address within the paradigms of traditional pharmacology. They include: determination of the mechanism of action and dose, evaluation of potency, safety and toxicity, as well as upscale, delivery and identification of proper indications. Finally, novel potential approaches are proposed in which resident progenitor cells are targeted to regenerate the damaged tissue.

AB - Biological regeneration is proving to be an increasingly attractive alternative/complement to prosthetic replacement of tissues and organs. In cell-based therapeutic approaches, cells are manipulated in vitro and administered to patients as living and dynamic biological agents. In this review, we have focused on the regeneration of the injured joint surface to discuss novel issues that these new therapeutic agents raise and are difficult to address within the paradigms of traditional pharmacology. They include: determination of the mechanism of action and dose, evaluation of potency, safety and toxicity, as well as upscale, delivery and identification of proper indications. Finally, novel potential approaches are proposed in which resident progenitor cells are targeted to regenerate the damaged tissue.

KW - Biocompatible Materials

KW - Guided Tissue Regeneration

KW - Humans

KW - Joints

KW - Models, Biological

KW - Regenerative Medicine

KW - Stem Cells

KW - Tissue Engineering

U2 - 10.2217/17460751.1.1.59

DO - 10.2217/17460751.1.1.59

M3 - Article

C2 - 17465820

VL - 1

SP - 59

EP - 69

JO - Regenerative Medicine

JF - Regenerative Medicine

SN - 1746-0751

IS - 1

ER -