Resistance to abomasal nematodes and individual genetic variability in reindeer

S D Cote, A Stien, R J Irvine, J F Dallas, F Marshall, O Halvorsen, R Langvatn, S D Albon

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Resistance to parasites is believed to have a widespread influence on demographic and adaptive processes. In systems where parasites impose a fitness cost on their host, heterozygotes may be selected because they are more resistant to parasites than homozygotes. Our objective was to assess the relationships between genomewide individual heterozygosity and abomasal nematode burdens in female Svalbard reindeer (Rangifer tarandus platyrhynchus) after the effects of host age, locality, season, and year had been accounted for. Samples were obtained from 306 female reindeer that were culled and genotyped at nine microsatellite loci. Reindeer in our study populations are mainly parasitized by the gastrointestinal nematodes Ostertagia gruehneri and Marshallagia marshalli. The infection intensity of each parasite differed between subpopulations, and among host age classes, seasons and years. We found no significant relationships between abomasal worm burdens, or lumen and mucosa larvae, of either O. gruehneri or M. marshalli and individual heterozygosity ( or mean d(2)) alone or in interactions with host age, locality, and year. Although we analysed one of the largest data set available to date on gastrointestinal nematodes of a wild ruminant, we used a typical data set of nine genetic neutral markers that may have had low power to detect heterozygosity-fitness correlations. We conclude that the proportion of the variance in parasite resistance explained by individual heterozygosity for neutral genetic markers is low in Svalbard reindeer and in vertebrates in general, and we suggest that the candidate-gene approach might be more fruitful for further research on gene-fitness correlations.

Original languageEnglish
Pages (from-to)4159-4168
Number of pages10
JournalMolecular Ecology
Volume14
DOIs
Publication statusPublished - 2005

Keywords

  • heterozygosity
  • Marshallagia marshalli
  • Ostertagia gruehneri
  • Rangifer tarandus
  • reindeer
  • trichostrongyle nematodes
  • MAJOR HISTOCOMPATIBILITY COMPLEX
  • RANGIFER-TARANDUS-PLATYRHYNCHUS
  • PARASITE RESISTANCE
  • RED DEER
  • MICROSATELLITE LOCI
  • SVALBARD REINDEER
  • GASTROINTESTINAL NEMATODES
  • MULTILOCUS HETEROZYGOSITY
  • INBREEDING DEPRESSION
  • UNGULATE POPULATION

Cite this

Cote, S. D., Stien, A., Irvine, R. J., Dallas, J. F., Marshall, F., Halvorsen, O., ... Albon, S. D. (2005). Resistance to abomasal nematodes and individual genetic variability in reindeer. Molecular Ecology, 14, 4159-4168. https://doi.org/10.1111/j.1365-294X.2005.02733.x

Resistance to abomasal nematodes and individual genetic variability in reindeer. / Cote, S D ; Stien, A ; Irvine, R J ; Dallas, J F ; Marshall, F ; Halvorsen, O ; Langvatn, R ; Albon, S D .

In: Molecular Ecology, Vol. 14, 2005, p. 4159-4168.

Research output: Contribution to journalArticle

Cote, SD, Stien, A, Irvine, RJ, Dallas, JF, Marshall, F, Halvorsen, O, Langvatn, R & Albon, SD 2005, 'Resistance to abomasal nematodes and individual genetic variability in reindeer', Molecular Ecology, vol. 14, pp. 4159-4168. https://doi.org/10.1111/j.1365-294X.2005.02733.x
Cote, S D ; Stien, A ; Irvine, R J ; Dallas, J F ; Marshall, F ; Halvorsen, O ; Langvatn, R ; Albon, S D . / Resistance to abomasal nematodes and individual genetic variability in reindeer. In: Molecular Ecology. 2005 ; Vol. 14. pp. 4159-4168.
@article{22544f7f3ceb4c049aa8e8cb204c1142,
title = "Resistance to abomasal nematodes and individual genetic variability in reindeer",
abstract = "Resistance to parasites is believed to have a widespread influence on demographic and adaptive processes. In systems where parasites impose a fitness cost on their host, heterozygotes may be selected because they are more resistant to parasites than homozygotes. Our objective was to assess the relationships between genomewide individual heterozygosity and abomasal nematode burdens in female Svalbard reindeer (Rangifer tarandus platyrhynchus) after the effects of host age, locality, season, and year had been accounted for. Samples were obtained from 306 female reindeer that were culled and genotyped at nine microsatellite loci. Reindeer in our study populations are mainly parasitized by the gastrointestinal nematodes Ostertagia gruehneri and Marshallagia marshalli. The infection intensity of each parasite differed between subpopulations, and among host age classes, seasons and years. We found no significant relationships between abomasal worm burdens, or lumen and mucosa larvae, of either O. gruehneri or M. marshalli and individual heterozygosity ( or mean d(2)) alone or in interactions with host age, locality, and year. Although we analysed one of the largest data set available to date on gastrointestinal nematodes of a wild ruminant, we used a typical data set of nine genetic neutral markers that may have had low power to detect heterozygosity-fitness correlations. We conclude that the proportion of the variance in parasite resistance explained by individual heterozygosity for neutral genetic markers is low in Svalbard reindeer and in vertebrates in general, and we suggest that the candidate-gene approach might be more fruitful for further research on gene-fitness correlations.",
keywords = "heterozygosity, Marshallagia marshalli, Ostertagia gruehneri, Rangifer tarandus, reindeer, trichostrongyle nematodes, MAJOR HISTOCOMPATIBILITY COMPLEX, RANGIFER-TARANDUS-PLATYRHYNCHUS, PARASITE RESISTANCE, RED DEER, MICROSATELLITE LOCI, SVALBARD REINDEER, GASTROINTESTINAL NEMATODES, MULTILOCUS HETEROZYGOSITY, INBREEDING DEPRESSION, UNGULATE POPULATION",
author = "Cote, {S D} and A Stien and Irvine, {R J} and Dallas, {J F} and F Marshall and O Halvorsen and R Langvatn and Albon, {S D}",
year = "2005",
doi = "10.1111/j.1365-294X.2005.02733.x",
language = "English",
volume = "14",
pages = "4159--4168",
journal = "Molecular Ecology",
issn = "0962-1083",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Resistance to abomasal nematodes and individual genetic variability in reindeer

AU - Cote, S D

AU - Stien, A

AU - Irvine, R J

AU - Dallas, J F

AU - Marshall, F

AU - Halvorsen, O

AU - Langvatn, R

AU - Albon, S D

PY - 2005

Y1 - 2005

N2 - Resistance to parasites is believed to have a widespread influence on demographic and adaptive processes. In systems where parasites impose a fitness cost on their host, heterozygotes may be selected because they are more resistant to parasites than homozygotes. Our objective was to assess the relationships between genomewide individual heterozygosity and abomasal nematode burdens in female Svalbard reindeer (Rangifer tarandus platyrhynchus) after the effects of host age, locality, season, and year had been accounted for. Samples were obtained from 306 female reindeer that were culled and genotyped at nine microsatellite loci. Reindeer in our study populations are mainly parasitized by the gastrointestinal nematodes Ostertagia gruehneri and Marshallagia marshalli. The infection intensity of each parasite differed between subpopulations, and among host age classes, seasons and years. We found no significant relationships between abomasal worm burdens, or lumen and mucosa larvae, of either O. gruehneri or M. marshalli and individual heterozygosity ( or mean d(2)) alone or in interactions with host age, locality, and year. Although we analysed one of the largest data set available to date on gastrointestinal nematodes of a wild ruminant, we used a typical data set of nine genetic neutral markers that may have had low power to detect heterozygosity-fitness correlations. We conclude that the proportion of the variance in parasite resistance explained by individual heterozygosity for neutral genetic markers is low in Svalbard reindeer and in vertebrates in general, and we suggest that the candidate-gene approach might be more fruitful for further research on gene-fitness correlations.

AB - Resistance to parasites is believed to have a widespread influence on demographic and adaptive processes. In systems where parasites impose a fitness cost on their host, heterozygotes may be selected because they are more resistant to parasites than homozygotes. Our objective was to assess the relationships between genomewide individual heterozygosity and abomasal nematode burdens in female Svalbard reindeer (Rangifer tarandus platyrhynchus) after the effects of host age, locality, season, and year had been accounted for. Samples were obtained from 306 female reindeer that were culled and genotyped at nine microsatellite loci. Reindeer in our study populations are mainly parasitized by the gastrointestinal nematodes Ostertagia gruehneri and Marshallagia marshalli. The infection intensity of each parasite differed between subpopulations, and among host age classes, seasons and years. We found no significant relationships between abomasal worm burdens, or lumen and mucosa larvae, of either O. gruehneri or M. marshalli and individual heterozygosity ( or mean d(2)) alone or in interactions with host age, locality, and year. Although we analysed one of the largest data set available to date on gastrointestinal nematodes of a wild ruminant, we used a typical data set of nine genetic neutral markers that may have had low power to detect heterozygosity-fitness correlations. We conclude that the proportion of the variance in parasite resistance explained by individual heterozygosity for neutral genetic markers is low in Svalbard reindeer and in vertebrates in general, and we suggest that the candidate-gene approach might be more fruitful for further research on gene-fitness correlations.

KW - heterozygosity

KW - Marshallagia marshalli

KW - Ostertagia gruehneri

KW - Rangifer tarandus

KW - reindeer

KW - trichostrongyle nematodes

KW - MAJOR HISTOCOMPATIBILITY COMPLEX

KW - RANGIFER-TARANDUS-PLATYRHYNCHUS

KW - PARASITE RESISTANCE

KW - RED DEER

KW - MICROSATELLITE LOCI

KW - SVALBARD REINDEER

KW - GASTROINTESTINAL NEMATODES

KW - MULTILOCUS HETEROZYGOSITY

KW - INBREEDING DEPRESSION

KW - UNGULATE POPULATION

U2 - 10.1111/j.1365-294X.2005.02733.x

DO - 10.1111/j.1365-294X.2005.02733.x

M3 - Article

VL - 14

SP - 4159

EP - 4168

JO - Molecular Ecology

JF - Molecular Ecology

SN - 0962-1083

ER -