Abstract
The pleiotropic cytokine interleukin-6 (IL-6) has been demonstrated to increase during exercise. Little is known regarding the response of the soluble IL-6 receptors (sIL-6R and sgp130) during such exercise. The aim of the current study was to investigate the response of plasma IL-6, sIL-6R and sgp130 during fatiguing submaximal exercise in humans. Twelve participants underwent an incremental exercise test to exhaustion and one week later performed a submaximal exercise bout (96 +/- 6% lactate threshold) to volitional exhaustion. Blood samples taken at rest and immediately post exercise were analyzed for IL-6, sIL-6R and sgp130. IL-6 increased (P <0.01) by 8.4 +/- 8.9 pg ml(-1) (75.7%) during the exercise period. sIL-6R and sgp130 also increased (P <0.05) by 2.7 +/- 3.9 ng ml(-1) (9.6%) and 37.7 +/- 55.6 ng ml(-1) (9.6%), respectively. The current study is the first investigation to demonstrate that alongside IL-6, acute exercise stress results in an increase in both sIL-6R and sgp130.
Original language | English |
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Pages (from-to) | 247-251 |
Number of pages | 5 |
Journal | Cell Stress & Chaperones |
Volume | 13 |
Issue number | 2 |
Early online date | 5 Mar 2008 |
DOIs | |
Publication status | Published - Jun 2008 |
Keywords
- adult
- blood volume
- cytokine receptor gp130
- exercise test
- fatigue
- heart rate
- humans
- interleukin-6
- lactates
- male
- middle aged
- motor activity
- oxygen consumption
- physical exertion
- receptors, interleukin-6
- solubility
- Exercise stress
- Interleukin-6
- Receptors
- Fatigue