Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men

Stuart Robert Gray, M Robinson, M A Nimmo

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The pleiotropic cytokine interleukin-6 (IL-6) has been demonstrated to increase during exercise. Little is known regarding the response of the soluble IL-6 receptors (sIL-6R and sgp130) during such exercise. The aim of the current study was to investigate the response of plasma IL-6, sIL-6R and sgp130 during fatiguing submaximal exercise in humans. Twelve participants underwent an incremental exercise test to exhaustion and one week later performed a submaximal exercise bout (96 +/- 6% lactate threshold) to volitional exhaustion. Blood samples taken at rest and immediately post exercise were analyzed for IL-6, sIL-6R and sgp130. IL-6 increased (P <0.01) by 8.4 +/- 8.9 pg ml(-1) (75.7%) during the exercise period. sIL-6R and sgp130 also increased (P <0.05) by 2.7 +/- 3.9 ng ml(-1) (9.6%) and 37.7 +/- 55.6 ng ml(-1) (9.6%), respectively. The current study is the first investigation to demonstrate that alongside IL-6, acute exercise stress results in an increase in both sIL-6R and sgp130.
Original languageEnglish
Pages (from-to)247-251
Number of pages5
JournalCell Stress & Chaperones
Volume13
Issue number2
Early online date5 Mar 2008
DOIs
Publication statusPublished - Jun 2008

Keywords

  • adult
  • blood volume
  • cytokine receptor gp130
  • exercise test
  • fatigue
  • heart rate
  • humans
  • interleukin-6
  • lactates
  • male
  • middle aged
  • motor activity
  • oxygen consumption
  • physical exertion
  • receptors, interleukin-6
  • solubility
  • Exercise stress
  • Interleukin-6
  • Receptors
  • Fatigue

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