Retinal development and function in a 'blind' mole

F David Carmona, Martin Glosmann, Jingxing Ou, Rafael Jiménez, J Martin Collinson

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Animals adapted to dark ecotopes may experience selective pressure for retinal reduction. No previous studies have explicitly addressed the molecular basis of retinal development in any fossorial mammal. We studied retinal development and function in the Iberian mole Talpa occidentalis, which was presumed to be blind because of its permanently closed eyes. Prenatal retina development was relatively normal, with specification of all cell types and evidence of dorsoventral regionalization. Severe developmental defects occurred after birth, subsequent to lens abnormalities. ‘Blind’ Iberian moles had rods, cones and rod nuclear ultrastructure typical of diurnal mammals. DiI staining revealed only contralateral projections through the optic chiasm. Y-maze experiments demonstrated that moles retain a photoavoidance response. Over-representation of melanopsin-positive retinal ganglion cells that mediate photoperiodicity was observed. Hence, molecular pathways of eye development in Iberian moles retain the adaptive function of rod/cone primary vision and photoperiodicity, with no evidence that moles are likely to completely lose their eyes on an evolutionary time scale.
Original languageEnglish
Pages (from-to)1513-1522
Number of pages10
JournalProceedings of the Royal Society of London. B, Biological Sciences
Volume277
Issue number1687
Early online date9 Dec 2009
DOIs
Publication statusPublished - 22 May 2010

Fingerprint

Mammals
Cones
Vertebrate Photoreceptor Cells
rods (retina)
photoperiodism
mammal
eyes
cones (retina)
Optic Chiasm
Lenses
Optics
Animals
Retinal Ganglion Cells
ultrastructure
regionalization
abnormality
Specifications
Defects
Talpa
defect

Keywords

  • Iberian mole
  • fossorial
  • evolution
  • retina development
  • melanopsin
  • gliosis

Cite this

Retinal development and function in a 'blind' mole. / Carmona, F David; Glosmann, Martin; Ou, Jingxing; Jiménez, Rafael; Collinson, J Martin.

In: Proceedings of the Royal Society of London. B, Biological Sciences, Vol. 277, No. 1687, 22.05.2010, p. 1513-1522.

Research output: Contribution to journalArticle

Carmona, F David ; Glosmann, Martin ; Ou, Jingxing ; Jiménez, Rafael ; Collinson, J Martin. / Retinal development and function in a 'blind' mole. In: Proceedings of the Royal Society of London. B, Biological Sciences. 2010 ; Vol. 277, No. 1687. pp. 1513-1522.
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