Retinoic Acid Signalling in Neuropsychiatric Disease

Possible Markers and Treatment Agents

Sarah J Bailey, Peter J McCaffery

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Retinoic acid is the transcriptionally active product of vitamin A, potentially controlling expression of several hundred genes through activation of specific nuclear receptors. The retinoic acid receptors (RARs) are expressed through much of the adult brain; in contrast the ligand for these receptors is much more restricted in its extent of expression. Non-liganded RARs likely control function through transcriptional repression whereas ligand activated receptors probably regulate more restricted functions including neuroplasticity and neurogenesis. Deregulation of retinoic acid signalling through application of excess levels of this ligand have been associated with depression while genetic and anatomical evidence has linked retinoic acid with the neurodevelopmental hypothesis of schizophrenia and autism. The RARs frequently act in conjunction with the second class of retinoid receptors, the retinoid X receptors (RXRs). These RXRs heterodimerize with other classes of nuclear receptors, including the thyroid hormone receptor which, like those for retinoic acid, are associated with schizophrenia and depression. It is possible that drugs that act on RXRs may be particularly effective in psychiatric disease by acting simultaneously on several nuclear receptor signalling pathways
Original languageEnglish
Title of host publicationThe Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes
Subtitle of host publicationVolume III: Metabolic and Peripheral Biomarkers
EditorsM Ritsner
Place of PublicationDordrecht, Netherlands
PublisherSpringer Science+Business Media
Pages171-190
Number of pages20
Volume3
ISBN (Electronic)978-1402098383
ISBN (Print)1402098375, 978-1402098376
DOIs
Publication statusPublished - 25 May 2009

Publication series

NameThe Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes
PublisherSpringer Science+Business Media
Volume3

Fingerprint

Tretinoin
Retinoid X Receptors
Retinoic Acid Receptors
Cytoplasmic and Nuclear Receptors
Ligands
Schizophrenia
Depression
Thyroid Hormone Receptors
Neuronal Plasticity
Neurogenesis
Retinoids
Autistic Disorder
Vitamin A
Transcriptional Activation
Psychiatry
Brain
Pharmaceutical Preparations

Cite this

Bailey, S. J., & McCaffery, P. J. (2009). Retinoic Acid Signalling in Neuropsychiatric Disease: Possible Markers and Treatment Agents. In M. Ritsner (Ed.), The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes: Volume III: Metabolic and Peripheral Biomarkers (Vol. 3, pp. 171-190). (The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes; Vol. 3). Dordrecht, Netherlands: Springer Science+Business Media. https://doi.org/10.1007/978-1-4020-9838-3_11

Retinoic Acid Signalling in Neuropsychiatric Disease : Possible Markers and Treatment Agents. / Bailey, Sarah J; McCaffery, Peter J.

The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes: Volume III: Metabolic and Peripheral Biomarkers. ed. / M Ritsner . Vol. 3 Dordrecht, Netherlands : Springer Science+Business Media, 2009. p. 171-190 (The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes; Vol. 3).

Research output: Chapter in Book/Report/Conference proceedingChapter

Bailey, SJ & McCaffery, PJ 2009, Retinoic Acid Signalling in Neuropsychiatric Disease: Possible Markers and Treatment Agents. in M Ritsner (ed.), The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes: Volume III: Metabolic and Peripheral Biomarkers. vol. 3, The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes, vol. 3, Springer Science+Business Media, Dordrecht, Netherlands, pp. 171-190. https://doi.org/10.1007/978-1-4020-9838-3_11
Bailey SJ, McCaffery PJ. Retinoic Acid Signalling in Neuropsychiatric Disease: Possible Markers and Treatment Agents. In Ritsner M, editor, The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes: Volume III: Metabolic and Peripheral Biomarkers. Vol. 3. Dordrecht, Netherlands: Springer Science+Business Media. 2009. p. 171-190. (The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes). https://doi.org/10.1007/978-1-4020-9838-3_11
Bailey, Sarah J ; McCaffery, Peter J. / Retinoic Acid Signalling in Neuropsychiatric Disease : Possible Markers and Treatment Agents. The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes: Volume III: Metabolic and Peripheral Biomarkers. editor / M Ritsner . Vol. 3 Dordrecht, Netherlands : Springer Science+Business Media, 2009. pp. 171-190 (The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes).
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