Rheumatoid arthritis association at 6q23

Wendy Thomson; Anne Barton; Xiayi Ke; Steve Eyre; Anne Hinks; John Bowes; Rachelle Donn; Deborah Symmons; Samantha Hider; Ian N. Bruce; Anthony G. Wilson; Ioanna Marinou; Ann Morgan; Paul Emery; Angela Carter; Sophia Steer; Lynne Hocking; David M Reid; Paul Wordsworth; Pille Harrison; David Strachan; Jane Worthington; Wellcome Trust Case Control Consortium

doi:10.1038/ng.2007.32

Rheumatoid arthritis association at 6q23

Wendy Thomson, Anne Barton, Xiayi Ke, Steve Eyre, Anne Hinks, John Bowes, Rachelle Donn, Deborah Symmons, Samantha Hider, Ian N. Bruce, Anthony G. Wilson, Ioanna Marinou, Ann Morgan, Paul Emery, Angela Carter, Sophia Steer, Lynne Hocking, David M Reid, Paul Wordsworth, Pille HarrisonDavid Strachan, Jane Worthington, Wellcome Trust Case Control Consortium

Applied Medicine

Research output: Contribution to journal › Article › peer-review

329 Citations (Scopus)

Abstract

The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5)-5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated ( trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 ( TNFAIP3).

Original language	English
Pages (from-to)	1431-1433
Number of pages	3
Journal	Nature Genetics
Volume	39
Issue number	12
Early online date	4 Nov 2007
DOIs	https://doi.org/10.1038/ng.2007.32
Publication status	Published - Dec 2007

Keywords

NF-KAPPA-B
population
responses
PTPN22
risk
gene
A20

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10.1038/ng.2007.32

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Thomson, W., Barton, A., Ke, X., Eyre, S., Hinks, A., Bowes, J., Donn, R., Symmons, D., Hider, S., Bruce, I. N., Wilson, A. G., Marinou, I., Morgan, A., Emery, P., Carter, A., Steer, S., Hocking, L., Reid, D. M., Wordsworth, P., ... Wellcome Trust Case Control Consortium (2007). Rheumatoid arthritis association at 6q23. Nature Genetics, 39(12), 1431-1433. https://doi.org/10.1038/ng.2007.32

Thomson, W, Barton, A, Ke, X, Eyre, S, Hinks, A, Bowes, J, Donn, R, Symmons, D, Hider, S, Bruce, IN, Wilson, AG, Marinou, I, Morgan, A, Emery, P, Carter, A, Steer, S, Hocking, L, Reid, DM, Wordsworth, P, Harrison, P, Strachan, D, Worthington, J & Wellcome Trust Case Control Consortium 2007, 'Rheumatoid arthritis association at 6q23', Nature Genetics, vol. 39, no. 12, pp. 1431-1433. https://doi.org/10.1038/ng.2007.32

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author = "Wendy Thomson and Anne Barton and Xiayi Ke and Steve Eyre and Anne Hinks and John Bowes and Rachelle Donn and Deborah Symmons and Samantha Hider and Bruce, {Ian N.} and Wilson, {Anthony G.} and Ioanna Marinou and Ann Morgan and Paul Emery and Angela Carter and Sophia Steer and Lynne Hocking and Reid, {David M} and Paul Wordsworth and Pille Harrison and David Strachan and Jane Worthington and {Wellcome Trust Case Control Consortium}",

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AU - Thomson, Wendy

AU - Barton, Anne

AU - Ke, Xiayi

AU - Eyre, Steve

AU - Hinks, Anne

AU - Bowes, John

AU - Donn, Rachelle

AU - Symmons, Deborah

AU - Hider, Samantha

AU - Bruce, Ian N.

AU - Wilson, Anthony G.

AU - Marinou, Ioanna

AU - Morgan, Ann

AU - Emery, Paul

AU - Carter, Angela

AU - Steer, Sophia

AU - Hocking, Lynne

AU - Reid, David M

AU - Wordsworth, Paul

AU - Harrison, Pille

AU - Strachan, David

AU - Worthington, Jane

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KW - NF-KAPPA-B

KW - population

KW - responses

KW - PTPN22

KW - risk

KW - gene

KW - A20

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JO - Nature Genetics

JF - Nature Genetics

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Rheumatoid arthritis association at 6q23

Abstract

Keywords

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