Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Anne Barton; Wendy Thomson; Xiayi Ke; Steve Eyre; Anne Hinks; John Bowes; Darren Plant; Laura J. Gibbons; Wellcome Trust Case Control Consortium; YEAR Consortium; BIRAC consortium; Anthony G. Wilson; Deborah E. Bax; Ann W. Morgan; Paul Emery; Sophia Steer; Lynne Hocking; David M Reid; Paul Wordsworth; Pille Harrison; Jane Worthington

doi:10.1038/ng.218

Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Anne Barton (Corresponding Author), Wendy Thomson, Xiayi Ke, Steve Eyre, Anne Hinks, John Bowes, Darren Plant, Laura J. Gibbons, Wellcome Trust Case Control Consortium, YEAR Consortium, BIRAC consortium, Anthony G. Wilson, Deborah E. Bax, Ann W. Morgan, Paul Emery, Sophia Steer, Lynne Hocking, David M Reid, Paul Wordsworth, Pille HarrisonJane Worthington

Applied Medicine

Research output: Contribution to journal › Article › peer-review

133 Citations (Scopus)

Abstract

The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

Original language	English
Pages (from-to)	1156-1159
Number of pages	4
Journal	Nature Genetics
Volume	40
Early online date	14 Sept 2008
DOIs	https://doi.org/10.1038/ng.218
Publication status	Published - 2008

Keywords

GENOME-WIDE ASSOCIATION
EXPRESSION
PATHWAY
6Q23
RISK

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Barton, A., Thomson, W., Ke, X., Eyre, S., Hinks, A., Bowes, J., Plant, D., Gibbons, L. J., Wellcome Trust Case Control Consortium, YEAR Consortium, BIRAC consortium, Wilson, A. G., Bax, D. E., Morgan, A. W., Emery, P., Steer, S., Hocking, L., Reid, D. M., Wordsworth, P., ... Worthington, J. (2008). Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nature Genetics, 40, 1156-1159. https://doi.org/10.1038/ng.218

Barton, A, Thomson, W, Ke, X, Eyre, S, Hinks, A, Bowes, J, Plant, D, Gibbons, LJ, Wellcome Trust Case Control Consortium, YEAR Consortium, BIRAC consortium, Wilson, AG, Bax, DE, Morgan, AW, Emery, P, Steer, S, Hocking, L, Reid, DM, Wordsworth, P, Harrison, P & Worthington, J 2008, 'Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13', Nature Genetics, vol. 40, pp. 1156-1159. https://doi.org/10.1038/ng.218

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title = "Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13",

abstract = "The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.",

keywords = "GENOME-WIDE ASSOCIATION, EXPRESSION, PATHWAY, 6Q23, RISK",

author = "Anne Barton and Wendy Thomson and Xiayi Ke and Steve Eyre and Anne Hinks and John Bowes and Darren Plant and Gibbons, {Laura J.} and {Wellcome Trust Case Control Consortium} and {YEAR Consortium} and {BIRAC consortium} and Wilson, {Anthony G.} and Bax, {Deborah E.} and Morgan, {Ann W.} and Paul Emery and Sophia Steer and Lynne Hocking and Reid, {David M} and Paul Wordsworth and Pille Harrison and Jane Worthington",

year = "2008",

doi = "10.1038/ng.218",

language = "English",

volume = "40",

pages = "1156--1159",

journal = "Nature Genetics",

issn = "1061-4036",

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AU - Barton, Anne

AU - Thomson, Wendy

AU - Ke, Xiayi

AU - Eyre, Steve

AU - Hinks, Anne

AU - Bowes, John

AU - Plant, Darren

AU - Gibbons, Laura J.

AU - Wellcome Trust Case Control Consortium

AU - YEAR Consortium

AU - BIRAC consortium

AU - Wilson, Anthony G.

AU - Bax, Deborah E.

AU - Morgan, Ann W.

AU - Emery, Paul

AU - Steer, Sophia

AU - Hocking, Lynne

AU - Reid, David M

AU - Wordsworth, Paul

AU - Harrison, Pille

AU - Worthington, Jane

PY - 2008

Y1 - 2008

N2 - The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

AB - The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

KW - GENOME-WIDE ASSOCIATION

KW - EXPRESSION

KW - PATHWAY

KW - 6Q23

KW - RISK

U2 - 10.1038/ng.218

DO - 10.1038/ng.218

M3 - Article

SN - 1061-4036

VL - 40

SP - 1156

EP - 1159

JO - Nature Genetics

JF - Nature Genetics

ER -

Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Abstract

Keywords

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