Ribosomally synthesized and post-translationally modified peptide natural products

Overview and recommendations for a universal nomenclature

Paul G. Arnison, Mervyn J. Bibb, Gabriele Bierbaum, Albert A. Bowers, Tim S. Bugni, Grzegorz Bulaj, Julio A. Camarero, Dominic J. Campopiano, Gregory L. Challis, Jon Clardy, Paul D. Cotter, David J. Craik, Michael Dawson, Elke Dittmann, Stefano Donadio, Pieter C. Dorrestein, Karl-Dieter Entian, Michael A. Fischbach, John S. Garavelli, Ulf Göransson & 45 others Christian W. Gruber, Daniel H. Haft, Thomas K. Hemscheidt, Christian Hertweck, Colin Hill, Alexander R. Horswill, Marcel Jaspars, Wendy L. Kelly, Judith P. Klinman, Oscar P. Kuipers, A. James Link, Wen Liu, Mohamed A. Marahiel, Douglas A. Mitchell, Gert N. Moll, Bradley S. Moore, Rolf Müller, Satish K. Nair, Ingolf F. Nes, Gillian E. Norris, Baldomero M. Olivera, Hiroyasu Onaka, Mark L. Patchett, Joern Piel, Martin J. T. Reaney, Sylvie Rebuffat, R. Paul Ross, Hans-Georg Sahl, Eric W. Schmidt, Michael E. Selsted, Konstantin Severinov, Ben Shen, Kaarina Sivonen, Leif Smith, Torsten Stein, Roderich D. Süssmuth, John R. Tagg, Gong-Li Tang, Andrew W. Truman, John C. Vederas, Christopher T. Walsh, Jonathan D. Walton, Silke C. Wenzel, Joanne M. Willey, Wilfred A. van der Donk

Research output: Contribution to journalArticle

771 Citations (Scopus)

Abstract

Covering: 1988 to 2012

This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The current knowledge regarding the biosynthesis of the >20 distinct compound classes is also reviewed, and commonalities are discussed.

Original languageEnglish
Pages (from-to)108-160
Number of pages53
JournalNatural Product Reports
Volume30
Issue number1
Early online date19 Nov 2012
DOIs
Publication statusPublished - Jan 2013

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Biosynthesis
Terminology
Biological Products
Peptides
compound 20

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Drug Discovery
  • Organic Chemistry

Cite this

Arnison, P. G., Bibb, M. J., Bierbaum, G., Bowers, A. A., Bugni, T. S., Bulaj, G., ... van der Donk, W. A. (2013). Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature. Natural Product Reports, 30(1), 108-160. https://doi.org/10.1039/c2np20085f

Ribosomally synthesized and post-translationally modified peptide natural products : Overview and recommendations for a universal nomenclature. / Arnison, Paul G.; Bibb, Mervyn J.; Bierbaum, Gabriele; Bowers, Albert A.; Bugni, Tim S.; Bulaj, Grzegorz; Camarero, Julio A.; Campopiano, Dominic J.; Challis, Gregory L.; Clardy, Jon; Cotter, Paul D.; Craik, David J.; Dawson, Michael; Dittmann, Elke; Donadio, Stefano; Dorrestein, Pieter C.; Entian, Karl-Dieter; Fischbach, Michael A.; Garavelli, John S.; Göransson, Ulf; Gruber, Christian W.; Haft, Daniel H.; Hemscheidt, Thomas K.; Hertweck, Christian; Hill, Colin; Horswill, Alexander R.; Jaspars, Marcel; Kelly, Wendy L.; Klinman, Judith P.; Kuipers, Oscar P.; Link, A. James; Liu, Wen; Marahiel, Mohamed A.; Mitchell, Douglas A.; Moll, Gert N.; Moore, Bradley S.; Müller, Rolf; Nair, Satish K.; Nes, Ingolf F.; Norris, Gillian E.; Olivera, Baldomero M.; Onaka, Hiroyasu; Patchett, Mark L.; Piel, Joern; Reaney, Martin J. T.; Rebuffat, Sylvie; Ross, R. Paul; Sahl, Hans-Georg; Schmidt, Eric W.; Selsted, Michael E.; Severinov, Konstantin; Shen, Ben; Sivonen, Kaarina; Smith, Leif; Stein, Torsten; Süssmuth, Roderich D.; Tagg, John R.; Tang, Gong-Li; Truman, Andrew W.; Vederas, John C.; Walsh, Christopher T.; Walton, Jonathan D.; Wenzel, Silke C.; Willey, Joanne M.; van der Donk, Wilfred A.

In: Natural Product Reports, Vol. 30, No. 1, 01.2013, p. 108-160.

Research output: Contribution to journalArticle

Arnison, PG, Bibb, MJ, Bierbaum, G, Bowers, AA, Bugni, TS, Bulaj, G, Camarero, JA, Campopiano, DJ, Challis, GL, Clardy, J, Cotter, PD, Craik, DJ, Dawson, M, Dittmann, E, Donadio, S, Dorrestein, PC, Entian, K-D, Fischbach, MA, Garavelli, JS, Göransson, U, Gruber, CW, Haft, DH, Hemscheidt, TK, Hertweck, C, Hill, C, Horswill, AR, Jaspars, M, Kelly, WL, Klinman, JP, Kuipers, OP, Link, AJ, Liu, W, Marahiel, MA, Mitchell, DA, Moll, GN, Moore, BS, Müller, R, Nair, SK, Nes, IF, Norris, GE, Olivera, BM, Onaka, H, Patchett, ML, Piel, J, Reaney, MJT, Rebuffat, S, Ross, RP, Sahl, H-G, Schmidt, EW, Selsted, ME, Severinov, K, Shen, B, Sivonen, K, Smith, L, Stein, T, Süssmuth, RD, Tagg, JR, Tang, G-L, Truman, AW, Vederas, JC, Walsh, CT, Walton, JD, Wenzel, SC, Willey, JM & van der Donk, WA 2013, 'Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature', Natural Product Reports, vol. 30, no. 1, pp. 108-160. https://doi.org/10.1039/c2np20085f
Arnison, Paul G. ; Bibb, Mervyn J. ; Bierbaum, Gabriele ; Bowers, Albert A. ; Bugni, Tim S. ; Bulaj, Grzegorz ; Camarero, Julio A. ; Campopiano, Dominic J. ; Challis, Gregory L. ; Clardy, Jon ; Cotter, Paul D. ; Craik, David J. ; Dawson, Michael ; Dittmann, Elke ; Donadio, Stefano ; Dorrestein, Pieter C. ; Entian, Karl-Dieter ; Fischbach, Michael A. ; Garavelli, John S. ; Göransson, Ulf ; Gruber, Christian W. ; Haft, Daniel H. ; Hemscheidt, Thomas K. ; Hertweck, Christian ; Hill, Colin ; Horswill, Alexander R. ; Jaspars, Marcel ; Kelly, Wendy L. ; Klinman, Judith P. ; Kuipers, Oscar P. ; Link, A. James ; Liu, Wen ; Marahiel, Mohamed A. ; Mitchell, Douglas A. ; Moll, Gert N. ; Moore, Bradley S. ; Müller, Rolf ; Nair, Satish K. ; Nes, Ingolf F. ; Norris, Gillian E. ; Olivera, Baldomero M. ; Onaka, Hiroyasu ; Patchett, Mark L. ; Piel, Joern ; Reaney, Martin J. T. ; Rebuffat, Sylvie ; Ross, R. Paul ; Sahl, Hans-Georg ; Schmidt, Eric W. ; Selsted, Michael E. ; Severinov, Konstantin ; Shen, Ben ; Sivonen, Kaarina ; Smith, Leif ; Stein, Torsten ; Süssmuth, Roderich D. ; Tagg, John R. ; Tang, Gong-Li ; Truman, Andrew W. ; Vederas, John C. ; Walsh, Christopher T. ; Walton, Jonathan D. ; Wenzel, Silke C. ; Willey, Joanne M. ; van der Donk, Wilfred A. / Ribosomally synthesized and post-translationally modified peptide natural products : Overview and recommendations for a universal nomenclature. In: Natural Product Reports. 2013 ; Vol. 30, No. 1. pp. 108-160.
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title = "Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature",
abstract = "Covering: 1988 to 2012This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The current knowledge regarding the biosynthesis of the >20 distinct compound classes is also reviewed, and commonalities are discussed.",
author = "Arnison, {Paul G.} and Bibb, {Mervyn J.} and Gabriele Bierbaum and Bowers, {Albert A.} and Bugni, {Tim S.} and Grzegorz Bulaj and Camarero, {Julio A.} and Campopiano, {Dominic J.} and Challis, {Gregory L.} and Jon Clardy and Cotter, {Paul D.} and Craik, {David J.} and Michael Dawson and Elke Dittmann and Stefano Donadio and Dorrestein, {Pieter C.} and Karl-Dieter Entian and Fischbach, {Michael A.} and Garavelli, {John S.} and Ulf G{\"o}ransson and Gruber, {Christian W.} and Haft, {Daniel H.} and Hemscheidt, {Thomas K.} and Christian Hertweck and Colin Hill and Horswill, {Alexander R.} and Marcel Jaspars and Kelly, {Wendy L.} and Klinman, {Judith P.} and Kuipers, {Oscar P.} and Link, {A. James} and Wen Liu and Marahiel, {Mohamed A.} and Mitchell, {Douglas A.} and Moll, {Gert N.} and Moore, {Bradley S.} and Rolf M{\"u}ller and Nair, {Satish K.} and Nes, {Ingolf F.} and Norris, {Gillian E.} and Olivera, {Baldomero M.} and Hiroyasu Onaka and Patchett, {Mark L.} and Joern Piel and Reaney, {Martin J. T.} and Sylvie Rebuffat and Ross, {R. Paul} and Hans-Georg Sahl and Schmidt, {Eric W.} and Selsted, {Michael E.} and Konstantin Severinov and Ben Shen and Kaarina Sivonen and Leif Smith and Torsten Stein and S{\"u}ssmuth, {Roderich D.} and Tagg, {John R.} and Gong-Li Tang and Truman, {Andrew W.} and Vederas, {John C.} and Walsh, {Christopher T.} and Walton, {Jonathan D.} and Wenzel, {Silke C.} and Willey, {Joanne M.} and {van der Donk}, {Wilfred A.}",
note = "Acknowledgements The recommendations in this review were compiled from the answers to two sets of successive questionnaires. Several discussion groups then made recommendations to the entire group of authors. The discussion groups were led by David Craik (cyclotides), Elke Dittmann (microviridins), Baldomero Olivera (conopeptides), Sylvie Rebuffat (microcins), Eric Schmidt (cyanobactins and LAPs), Wilfred van der Donk (lanthipeptides and glycocins), John Vederas (sactipeptides and N-to-C cyclized peptides), and Christopher Walsh (thiopeptides). The final write-ups for the several classes of compounds were provided by David Craik (cyclotides), Elke Dittmann (microviridins), Wendy Kelly (thiopeptides), Douglas Mitchell (LAPs), Joern Piel (proteusins), Baldomero Olivera (conopeptides), Martin Reaney (orbitides), Sylvie Rebuffat (microcins and lasso peptides), Eric Schmidt (cyanobactins), Wilfred van der Donk (introduction, lanthipeptides, linaridins, bottromycins, glycocins, quorum sensing peptides, PQQ, methanobactin, linear nomenclature, and outlook) and John Vederas (sactipeptides, N-to-C cyclized peptides, linear nomenclature). Coordination of the discussions and assembly and editing of the final review was done by Wilfred van der Donk. We thank Dr Qi Zhang (UIUC) for help with illustrations.",
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TY - JOUR

T1 - Ribosomally synthesized and post-translationally modified peptide natural products

T2 - Overview and recommendations for a universal nomenclature

AU - Arnison, Paul G.

AU - Bibb, Mervyn J.

AU - Bierbaum, Gabriele

AU - Bowers, Albert A.

AU - Bugni, Tim S.

AU - Bulaj, Grzegorz

AU - Camarero, Julio A.

AU - Campopiano, Dominic J.

AU - Challis, Gregory L.

AU - Clardy, Jon

AU - Cotter, Paul D.

AU - Craik, David J.

AU - Dawson, Michael

AU - Dittmann, Elke

AU - Donadio, Stefano

AU - Dorrestein, Pieter C.

AU - Entian, Karl-Dieter

AU - Fischbach, Michael A.

AU - Garavelli, John S.

AU - Göransson, Ulf

AU - Gruber, Christian W.

AU - Haft, Daniel H.

AU - Hemscheidt, Thomas K.

AU - Hertweck, Christian

AU - Hill, Colin

AU - Horswill, Alexander R.

AU - Jaspars, Marcel

AU - Kelly, Wendy L.

AU - Klinman, Judith P.

AU - Kuipers, Oscar P.

AU - Link, A. James

AU - Liu, Wen

AU - Marahiel, Mohamed A.

AU - Mitchell, Douglas A.

AU - Moll, Gert N.

AU - Moore, Bradley S.

AU - Müller, Rolf

AU - Nair, Satish K.

AU - Nes, Ingolf F.

AU - Norris, Gillian E.

AU - Olivera, Baldomero M.

AU - Onaka, Hiroyasu

AU - Patchett, Mark L.

AU - Piel, Joern

AU - Reaney, Martin J. T.

AU - Rebuffat, Sylvie

AU - Ross, R. Paul

AU - Sahl, Hans-Georg

AU - Schmidt, Eric W.

AU - Selsted, Michael E.

AU - Severinov, Konstantin

AU - Shen, Ben

AU - Sivonen, Kaarina

AU - Smith, Leif

AU - Stein, Torsten

AU - Süssmuth, Roderich D.

AU - Tagg, John R.

AU - Tang, Gong-Li

AU - Truman, Andrew W.

AU - Vederas, John C.

AU - Walsh, Christopher T.

AU - Walton, Jonathan D.

AU - Wenzel, Silke C.

AU - Willey, Joanne M.

AU - van der Donk, Wilfred A.

N1 - Acknowledgements The recommendations in this review were compiled from the answers to two sets of successive questionnaires. Several discussion groups then made recommendations to the entire group of authors. The discussion groups were led by David Craik (cyclotides), Elke Dittmann (microviridins), Baldomero Olivera (conopeptides), Sylvie Rebuffat (microcins), Eric Schmidt (cyanobactins and LAPs), Wilfred van der Donk (lanthipeptides and glycocins), John Vederas (sactipeptides and N-to-C cyclized peptides), and Christopher Walsh (thiopeptides). The final write-ups for the several classes of compounds were provided by David Craik (cyclotides), Elke Dittmann (microviridins), Wendy Kelly (thiopeptides), Douglas Mitchell (LAPs), Joern Piel (proteusins), Baldomero Olivera (conopeptides), Martin Reaney (orbitides), Sylvie Rebuffat (microcins and lasso peptides), Eric Schmidt (cyanobactins), Wilfred van der Donk (introduction, lanthipeptides, linaridins, bottromycins, glycocins, quorum sensing peptides, PQQ, methanobactin, linear nomenclature, and outlook) and John Vederas (sactipeptides, N-to-C cyclized peptides, linear nomenclature). Coordination of the discussions and assembly and editing of the final review was done by Wilfred van der Donk. We thank Dr Qi Zhang (UIUC) for help with illustrations.

PY - 2013/1

Y1 - 2013/1

N2 - Covering: 1988 to 2012This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The current knowledge regarding the biosynthesis of the >20 distinct compound classes is also reviewed, and commonalities are discussed.

AB - Covering: 1988 to 2012This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The current knowledge regarding the biosynthesis of the >20 distinct compound classes is also reviewed, and commonalities are discussed.

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U2 - 10.1039/c2np20085f

DO - 10.1039/c2np20085f

M3 - Article

VL - 30

SP - 108

EP - 160

JO - Natural Product Reports

JF - Natural Product Reports

SN - 0265-0568

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