Rising incidence of pediatric inflammatory bowel disease in Scotland

Paul Henderson, Richard Hansen, Fiona Louise Cameron, Kostas Gerasimidis, Pam Rogers, W. Michael Bisset, Emma Reynish, Hazel E. Drummond, Niall Anderson, Johan Van Limbergen, Richard Kay Russell, Jack Satsangi, David C. Wilson

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Background:
An accurate indication of the changing incidence of pediatric inflammatory bowel disease (PIBD) within a population is useful in understanding concurrent etiological factors. We aimed to compare the current incidence and other demographic attributes of PIBD in the Scottish population to previous data.
Methods:
A national cohort of prospectively and retrospectively acquired incident cases of PIBD diagnosed less than 16 years old in pediatric services in Scotland was captured for the period 2003–2008; historical Scottish data were used for comparison (1990–1995). Age/sex-adjusted incidences were calculated and statistical comparisons made using Poisson regression.
Results:
During the 2003–2008 study period 436 patients were diagnosed with PIBD in Scotland, giving an adjusted incidence of 7.82/100,000/year. The incidence of Crohn's disease (CD) was 4.75/100,000/year, ulcerative colitis (UC) 2.06/100,000/year, and inflammatory bowel disease-unclassified (IBDU) 1.01/100,000/year. Compared with data from 1990–1995 when 260 IBD patients were diagnosed, significant rises in the incidence of IBD (from 4.45/100,000/year, P < 0.0001), CD (from 2.86/100,000/year, P < 0.0001), and UC (from 1.59/100,000/year, P = 0.023) were seen. There was also a significant reduction in the median age at IBD diagnosis from 12.7 years to 11.9 years between the periods (P = 0.003), with a continued male preponderance.
Conclusions:
The number of Scottish children diagnosed with IBD continues to rise, with a statistically significant 76% increase since the mid-1990s. Furthermore, PIBD is now being diagnosed at a younger age. The reason for this continued rise is not yet clear; however, new hypotheses regarding disease pathogenesis and other population trends may provide further insights in future years.
Original languageEnglish
Pages (from-to)999-1005
Number of pages7
JournalInflammatory Bowel Diseases
Volume18
Issue number6
Early online date17 Jun 2011
DOIs
Publication statusPublished - Jun 2012

Fingerprint

Scotland
Inflammatory Bowel Diseases
Pediatrics
Incidence
Ulcerative Colitis
Crohn Disease
Population
Demography

Keywords

  • inflammatory bowel diseases
  • epidemiology
  • Crohn's disease
  • ulcerative colitis
  • childhood

Cite this

Henderson, P., Hansen, R., Cameron, F. L., Gerasimidis, K., Rogers, P., Bisset, W. M., ... Wilson, D. C. (2012). Rising incidence of pediatric inflammatory bowel disease in Scotland. Inflammatory Bowel Diseases, 18(6), 999-1005. https://doi.org/10.1002/ibd.21797

Rising incidence of pediatric inflammatory bowel disease in Scotland. / Henderson, Paul; Hansen, Richard; Cameron, Fiona Louise; Gerasimidis, Kostas; Rogers, Pam; Bisset, W. Michael; Reynish, Emma; Drummond, Hazel E.; Anderson, Niall; Van Limbergen, Johan; Russell, Richard Kay; Satsangi, Jack; Wilson, David C.

In: Inflammatory Bowel Diseases, Vol. 18, No. 6, 06.2012, p. 999-1005.

Research output: Contribution to journalArticle

Henderson, P, Hansen, R, Cameron, FL, Gerasimidis, K, Rogers, P, Bisset, WM, Reynish, E, Drummond, HE, Anderson, N, Van Limbergen, J, Russell, RK, Satsangi, J & Wilson, DC 2012, 'Rising incidence of pediatric inflammatory bowel disease in Scotland', Inflammatory Bowel Diseases, vol. 18, no. 6, pp. 999-1005. https://doi.org/10.1002/ibd.21797
Henderson P, Hansen R, Cameron FL, Gerasimidis K, Rogers P, Bisset WM et al. Rising incidence of pediatric inflammatory bowel disease in Scotland. Inflammatory Bowel Diseases. 2012 Jun;18(6):999-1005. https://doi.org/10.1002/ibd.21797
Henderson, Paul ; Hansen, Richard ; Cameron, Fiona Louise ; Gerasimidis, Kostas ; Rogers, Pam ; Bisset, W. Michael ; Reynish, Emma ; Drummond, Hazel E. ; Anderson, Niall ; Van Limbergen, Johan ; Russell, Richard Kay ; Satsangi, Jack ; Wilson, David C. / Rising incidence of pediatric inflammatory bowel disease in Scotland. In: Inflammatory Bowel Diseases. 2012 ; Vol. 18, No. 6. pp. 999-1005.
@article{3437b906d3c643cc97790069ba64be5e,
title = "Rising incidence of pediatric inflammatory bowel disease in Scotland",
abstract = "Background: An accurate indication of the changing incidence of pediatric inflammatory bowel disease (PIBD) within a population is useful in understanding concurrent etiological factors. We aimed to compare the current incidence and other demographic attributes of PIBD in the Scottish population to previous data. Methods: A national cohort of prospectively and retrospectively acquired incident cases of PIBD diagnosed less than 16 years old in pediatric services in Scotland was captured for the period 2003–2008; historical Scottish data were used for comparison (1990–1995). Age/sex-adjusted incidences were calculated and statistical comparisons made using Poisson regression. Results: During the 2003–2008 study period 436 patients were diagnosed with PIBD in Scotland, giving an adjusted incidence of 7.82/100,000/year. The incidence of Crohn's disease (CD) was 4.75/100,000/year, ulcerative colitis (UC) 2.06/100,000/year, and inflammatory bowel disease-unclassified (IBDU) 1.01/100,000/year. Compared with data from 1990–1995 when 260 IBD patients were diagnosed, significant rises in the incidence of IBD (from 4.45/100,000/year, P < 0.0001), CD (from 2.86/100,000/year, P < 0.0001), and UC (from 1.59/100,000/year, P = 0.023) were seen. There was also a significant reduction in the median age at IBD diagnosis from 12.7 years to 11.9 years between the periods (P = 0.003), with a continued male preponderance. Conclusions: The number of Scottish children diagnosed with IBD continues to rise, with a statistically significant 76{\%} increase since the mid-1990s. Furthermore, PIBD is now being diagnosed at a younger age. The reason for this continued rise is not yet clear; however, new hypotheses regarding disease pathogenesis and other population trends may provide further insights in future years.",
keywords = "inflammatory bowel diseases, epidemiology, Crohn's disease, ulcerative colitis, childhood",
author = "Paul Henderson and Richard Hansen and Cameron, {Fiona Louise} and Kostas Gerasimidis and Pam Rogers and Bisset, {W. Michael} and Emma Reynish and Drummond, {Hazel E.} and Niall Anderson and {Van Limbergen}, Johan and Russell, {Richard Kay} and Jack Satsangi and Wilson, {David C.}",
year = "2012",
month = "6",
doi = "10.1002/ibd.21797",
language = "English",
volume = "18",
pages = "999--1005",
journal = "Inflammatory Bowel Diseases",
issn = "1078-0998",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - Rising incidence of pediatric inflammatory bowel disease in Scotland

AU - Henderson, Paul

AU - Hansen, Richard

AU - Cameron, Fiona Louise

AU - Gerasimidis, Kostas

AU - Rogers, Pam

AU - Bisset, W. Michael

AU - Reynish, Emma

AU - Drummond, Hazel E.

AU - Anderson, Niall

AU - Van Limbergen, Johan

AU - Russell, Richard Kay

AU - Satsangi, Jack

AU - Wilson, David C.

PY - 2012/6

Y1 - 2012/6

N2 - Background: An accurate indication of the changing incidence of pediatric inflammatory bowel disease (PIBD) within a population is useful in understanding concurrent etiological factors. We aimed to compare the current incidence and other demographic attributes of PIBD in the Scottish population to previous data. Methods: A national cohort of prospectively and retrospectively acquired incident cases of PIBD diagnosed less than 16 years old in pediatric services in Scotland was captured for the period 2003–2008; historical Scottish data were used for comparison (1990–1995). Age/sex-adjusted incidences were calculated and statistical comparisons made using Poisson regression. Results: During the 2003–2008 study period 436 patients were diagnosed with PIBD in Scotland, giving an adjusted incidence of 7.82/100,000/year. The incidence of Crohn's disease (CD) was 4.75/100,000/year, ulcerative colitis (UC) 2.06/100,000/year, and inflammatory bowel disease-unclassified (IBDU) 1.01/100,000/year. Compared with data from 1990–1995 when 260 IBD patients were diagnosed, significant rises in the incidence of IBD (from 4.45/100,000/year, P < 0.0001), CD (from 2.86/100,000/year, P < 0.0001), and UC (from 1.59/100,000/year, P = 0.023) were seen. There was also a significant reduction in the median age at IBD diagnosis from 12.7 years to 11.9 years between the periods (P = 0.003), with a continued male preponderance. Conclusions: The number of Scottish children diagnosed with IBD continues to rise, with a statistically significant 76% increase since the mid-1990s. Furthermore, PIBD is now being diagnosed at a younger age. The reason for this continued rise is not yet clear; however, new hypotheses regarding disease pathogenesis and other population trends may provide further insights in future years.

AB - Background: An accurate indication of the changing incidence of pediatric inflammatory bowel disease (PIBD) within a population is useful in understanding concurrent etiological factors. We aimed to compare the current incidence and other demographic attributes of PIBD in the Scottish population to previous data. Methods: A national cohort of prospectively and retrospectively acquired incident cases of PIBD diagnosed less than 16 years old in pediatric services in Scotland was captured for the period 2003–2008; historical Scottish data were used for comparison (1990–1995). Age/sex-adjusted incidences were calculated and statistical comparisons made using Poisson regression. Results: During the 2003–2008 study period 436 patients were diagnosed with PIBD in Scotland, giving an adjusted incidence of 7.82/100,000/year. The incidence of Crohn's disease (CD) was 4.75/100,000/year, ulcerative colitis (UC) 2.06/100,000/year, and inflammatory bowel disease-unclassified (IBDU) 1.01/100,000/year. Compared with data from 1990–1995 when 260 IBD patients were diagnosed, significant rises in the incidence of IBD (from 4.45/100,000/year, P < 0.0001), CD (from 2.86/100,000/year, P < 0.0001), and UC (from 1.59/100,000/year, P = 0.023) were seen. There was also a significant reduction in the median age at IBD diagnosis from 12.7 years to 11.9 years between the periods (P = 0.003), with a continued male preponderance. Conclusions: The number of Scottish children diagnosed with IBD continues to rise, with a statistically significant 76% increase since the mid-1990s. Furthermore, PIBD is now being diagnosed at a younger age. The reason for this continued rise is not yet clear; however, new hypotheses regarding disease pathogenesis and other population trends may provide further insights in future years.

KW - inflammatory bowel diseases

KW - epidemiology

KW - Crohn's disease

KW - ulcerative colitis

KW - childhood

U2 - 10.1002/ibd.21797

DO - 10.1002/ibd.21797

M3 - Article

VL - 18

SP - 999

EP - 1005

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

SN - 1078-0998

IS - 6

ER -