Risk factors in the development of Kaposis sarcoma

Rachel Colman, David J. Blackbourn

Research output: Contribution to journalEditorialpeer-review

13 Citations (Scopus)

Abstract

Kaposi's sarcoma is a multifocal malignancy observed in elderly Mediterranean men (so-called Classic Kaposi's sarcoma), individuals in Africa (endemic Kaposi's sarcoma) and patients with immune disorders, including those undergoing organ transplantation (iatrogenic Kaposi's sarcoma) or infected with HIV (epidemic Kaposi's sarcoma). In all of these four clinical categories of Kaposi's sarcoma, the tumour represents aberrant angiogenesis or lymphangiogenesis (i.e. formation of new blood or lymphatic vessels, respectively [1]) through proliferation of spindle-shaped endothelial cells that line these vascular structures.
Original languageEnglish
Pages (from-to)1629-1632
Number of pages4
JournalAIDS
Volume22
Issue number13
DOIs
Publication statusPublished - 20 Aug 2008

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