TY - JOUR
T1 - Risk of adverse outcomes following urinary tract infection in older people with renal impairment
T2 - Retrospective cohort study using linked health record data
AU - Ahmed, Haroon
AU - Farewell, Daniel
AU - Francis, Nick A.
AU - Paranjothy, Shantini
AU - Butler, Christopher C.
N1 - Funding: This report is independent research arising from a National Institute of Health Research (NIHR) Doctoral Research Fellowship awarded to HA, and supported by Health and Care Research Wales (HCRW) (grant number DRF-2014-07-010). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Data Availability: Data analysed for this study were obtained under institutional license from the Clinical Practice Research Datalink, https://www.cprd.com/intro.asp. Data are not available for sharing but can be applied for through the CPRD. Relevant information to allow acquisition of a replicable data set is available in the paper and its Supporting Information files.
PY - 2018/9/10
Y1 - 2018/9/10
N2 - Background Few studies have investigated the risk of adverse outcomes in older people with renal impairment presenting to primary care with a urinary tract infection (UTI). The aim of this study was to determine the risk of adverse outcomes in patients aged ?65 years presenting to primary care with a UTI, by estimated glomerular filtration rate (eGFR) and empirical prescription of nitrofurantoin versus trimethoprim. Methods and Findings This was a retrospective cohort study using linked health record data from 795,484 patients from 393 general practices in England, who were aged ?65 years between 2010 and 2016. Patients were entered into the cohort if they presented with a UTI and had a creatinine measurement in the 24 months prior to presentation. We calculated an eGFR to estimate risk of adverse outcomes by renal function, and propensity-score matched patients with eGFRs 60mls/min/1.73m2, patients with an eGFR of 60mls/min/1.73m2, patients with an eGFR of
AB - Background Few studies have investigated the risk of adverse outcomes in older people with renal impairment presenting to primary care with a urinary tract infection (UTI). The aim of this study was to determine the risk of adverse outcomes in patients aged ?65 years presenting to primary care with a UTI, by estimated glomerular filtration rate (eGFR) and empirical prescription of nitrofurantoin versus trimethoprim. Methods and Findings This was a retrospective cohort study using linked health record data from 795,484 patients from 393 general practices in England, who were aged ?65 years between 2010 and 2016. Patients were entered into the cohort if they presented with a UTI and had a creatinine measurement in the 24 months prior to presentation. We calculated an eGFR to estimate risk of adverse outcomes by renal function, and propensity-score matched patients with eGFRs 60mls/min/1.73m2, patients with an eGFR of 60mls/min/1.73m2, patients with an eGFR of
U2 - 10.1371/journal.pmed.1002652
DO - 10.1371/journal.pmed.1002652
M3 - Article
VL - 15
JO - PLoS Medicine
JF - PLoS Medicine
SN - 1549-1277
IS - 9
M1 - 1002652
ER -