Risk of adverse outcomes following urinary tract infection in older people with renal impairment: Retrospective cohort study using linked health record data

Haroon Ahmed* (Corresponding Author), Daniel Farewell, Nick A. Francis, Shantini Paranjothy, Christopher C. Butler

*Corresponding author for this work

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3 Citations (Scopus)

Abstract

Background Few studies have investigated the risk of adverse outcomes in older people with renal impairment presenting to primary care with a urinary tract infection (UTI). The aim of this study was to determine the risk of adverse outcomes in patients aged ?65 years presenting to primary care with a UTI, by estimated glomerular filtration rate (eGFR) and empirical prescription of nitrofurantoin versus trimethoprim. Methods and Findings This was a retrospective cohort study using linked health record data from 795,484 patients from 393 general practices in England, who were aged ?65 years between 2010 and 2016. Patients were entered into the cohort if they presented with a UTI and had a creatinine measurement in the 24 months prior to presentation. We calculated an eGFR to estimate risk of adverse outcomes by renal function, and propensity-score matched patients with eGFRs 60mls/min/1.73m2, patients with an eGFR of 60mls/min/1.73m2, patients with an eGFR of
Original languageEnglish
Article number1002652
Number of pages16
JournalPLoS Medicine
Volume15
Issue number9
Early online date10 Sep 2018
DOIs
Publication statusPublished - 10 Sep 2018

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