Abstract
Background Few studies have investigated the risk of adverse outcomes in older people with renal impairment presenting to primary care with a urinary tract infection (UTI). The aim of this study was to determine the risk of adverse outcomes in patients aged ?65 years presenting to primary care with a UTI, by estimated glomerular filtration rate (eGFR) and empirical prescription of nitrofurantoin versus trimethoprim. Methods and Findings This was a retrospective cohort study using linked health record data from 795,484 patients from 393 general practices in England, who were aged ?65 years between 2010 and 2016. Patients were entered into the cohort if they presented with a UTI and had a creatinine measurement in the 24 months prior to presentation. We calculated an eGFR to estimate risk of adverse outcomes by renal function, and propensity-score matched patients with eGFRs 60mls/min/1.73m2, patients with an eGFR of 60mls/min/1.73m2, patients with an eGFR of
Original language | English |
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Article number | 1002652 |
Number of pages | 16 |
Journal | PLoS Medicine |
Volume | 15 |
Issue number | 9 |
Early online date | 10 Sep 2018 |
DOIs | |
Publication status | Published - 10 Sep 2018 |
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Dive into the research topics of 'Risk of adverse outcomes following urinary tract infection in older people with renal impairment: Retrospective cohort study using linked health record data'. Together they form a unique fingerprint.Profiles
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Shantini Paranjothy
- School of Medicine, Medical Sciences & Nutrition, Applied Health Sciences - Clinical Chair in Public Health
Person: Clinical Academic