Risk of skin cancer after neonatal phototherapy

retrospective cohort study

David H Brewster, Janet S Tucker, Michael Fleming, Carole Morris, Diane L Stockton, David J Lloyd, Sohinee Bhattacharya, James W T Chalmers

Research output: Contribution to journalArticle

13 Citations (Scopus)
4 Downloads (Pure)

Abstract

Objective: To assess the risk of skin cancer in persons treated with neonatal phototherapy (NNPT) for jaundice.

Design: Retrospective cohort study.

Setting: Grampian Region, Scotland, UK.

Data source: Aberdeen Maternity and Neonatal Databank. NNPT exposure was abstracted from paper records spanning 1976-1990. Follow-up to 31 December 2006 by linkage to cancer registration and mortality records.

Main outcome measures: Indcidence ratios, standardised for age, sex, calendar period and socioeconomic position.

Results: After excluding neonatal deaths (n-435), the cohort comprised 77,518 persons. 5868 received NNPT, providing 138,000 person-years at risk (median follow-up, 24 years). Two cases of meanoma occured in persons exposed to NNPT versus 16 cases in unexposed persons, yielding a stadardised incidence ratio of 1.40 (95% CI, 0.17 to 5.04; p=0.834). No cases of squamous cell or basal cell carcinoma were observed in exposed persons.

Conclusions: Although there is no statistically significant evidence of an excess risk of skin cancer following NNPT, evidence available so far does not suggest a major cause for concern.
Original languageEnglish
Pages (from-to)826-831
Number of pages6
JournalArchives of Disease in Childhood
Volume95
Issue number10
Early online date23 Jun 2010
DOIs
Publication statusPublished - Oct 2010

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Phototherapy
Skin Neoplasms
Cohort Studies
Retrospective Studies
Neonatal Jaundice
Information Storage and Retrieval
Basal Cell Carcinoma
Scotland
Epithelial Cells
Outcome Assessment (Health Care)
Databases
Mortality
Incidence
Neoplasms

Cite this

Brewster, D. H., Tucker, J. S., Fleming, M., Morris, C., Stockton, D. L., Lloyd, D. J., ... Chalmers, J. W. T. (2010). Risk of skin cancer after neonatal phototherapy: retrospective cohort study. Archives of Disease in Childhood, 95(10), 826-831. https://doi.org/10.1136/adc.2009.179275

Risk of skin cancer after neonatal phototherapy : retrospective cohort study. / Brewster, David H; Tucker, Janet S; Fleming, Michael; Morris, Carole; Stockton, Diane L; Lloyd, David J; Bhattacharya, Sohinee; Chalmers, James W T.

In: Archives of Disease in Childhood, Vol. 95, No. 10, 10.2010, p. 826-831.

Research output: Contribution to journalArticle

Brewster, DH, Tucker, JS, Fleming, M, Morris, C, Stockton, DL, Lloyd, DJ, Bhattacharya, S & Chalmers, JWT 2010, 'Risk of skin cancer after neonatal phototherapy: retrospective cohort study', Archives of Disease in Childhood, vol. 95, no. 10, pp. 826-831. https://doi.org/10.1136/adc.2009.179275
Brewster DH, Tucker JS, Fleming M, Morris C, Stockton DL, Lloyd DJ et al. Risk of skin cancer after neonatal phototherapy: retrospective cohort study. Archives of Disease in Childhood. 2010 Oct;95(10):826-831. https://doi.org/10.1136/adc.2009.179275
Brewster, David H ; Tucker, Janet S ; Fleming, Michael ; Morris, Carole ; Stockton, Diane L ; Lloyd, David J ; Bhattacharya, Sohinee ; Chalmers, James W T. / Risk of skin cancer after neonatal phototherapy : retrospective cohort study. In: Archives of Disease in Childhood. 2010 ; Vol. 95, No. 10. pp. 826-831.
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abstract = "Objective: To assess the risk of skin cancer in persons treated with neonatal phototherapy (NNPT) for jaundice. Design: Retrospective cohort study. Setting: Grampian Region, Scotland, UK. Data source: Aberdeen Maternity and Neonatal Databank. NNPT exposure was abstracted from paper records spanning 1976-1990. Follow-up to 31 December 2006 by linkage to cancer registration and mortality records. Main outcome measures: Indcidence ratios, standardised for age, sex, calendar period and socioeconomic position. Results: After excluding neonatal deaths (n-435), the cohort comprised 77,518 persons. 5868 received NNPT, providing 138,000 person-years at risk (median follow-up, 24 years). Two cases of meanoma occured in persons exposed to NNPT versus 16 cases in unexposed persons, yielding a stadardised incidence ratio of 1.40 (95{\%} CI, 0.17 to 5.04; p=0.834). No cases of squamous cell or basal cell carcinoma were observed in exposed persons. Conclusions: Although there is no statistically significant evidence of an excess risk of skin cancer following NNPT, evidence available so far does not suggest a major cause for concern.",
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N2 - Objective: To assess the risk of skin cancer in persons treated with neonatal phototherapy (NNPT) for jaundice. Design: Retrospective cohort study. Setting: Grampian Region, Scotland, UK. Data source: Aberdeen Maternity and Neonatal Databank. NNPT exposure was abstracted from paper records spanning 1976-1990. Follow-up to 31 December 2006 by linkage to cancer registration and mortality records. Main outcome measures: Indcidence ratios, standardised for age, sex, calendar period and socioeconomic position. Results: After excluding neonatal deaths (n-435), the cohort comprised 77,518 persons. 5868 received NNPT, providing 138,000 person-years at risk (median follow-up, 24 years). Two cases of meanoma occured in persons exposed to NNPT versus 16 cases in unexposed persons, yielding a stadardised incidence ratio of 1.40 (95% CI, 0.17 to 5.04; p=0.834). No cases of squamous cell or basal cell carcinoma were observed in exposed persons. Conclusions: Although there is no statistically significant evidence of an excess risk of skin cancer following NNPT, evidence available so far does not suggest a major cause for concern.

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