Risk to human and animal health related to the presence of 4,15‐diacetoxyscirpenol in food and feed

Helle Katrine  Knutsen; Jan Alexander; Lars Barregård; Margherita Bignami; Beat  Brüschweiler; Sandra Ceccatelli; Bruce Cottrill; Michael Dinovi; Bettina  Grasl-Kraupp; Christer  Hogstrand; Laurentius (Ron)  Hoogenboom; Carlo Stefano  Nebbia; Isabelle P. Oswald; Annette  Petersen; Martin  Rose; Alain-Claude  Roudot; Tanja  Schwerdtle; Christiane  Vleminckx; Günter  Vollmer; Heather Wallace; Sarah De Saeger; Gunnar Sundstøl Eriksen; Peter Farmer; Jean-Marc Fremy; Yun Yun Gong; Karsten Meyer; Dominique  Parent-Massin; Hans van Egmond; Andrea Altieri; Paolo Colombo; Zsuzsanna Horvath; Sara Levorato; Lutz Edler; EFSA Panel on Contaminants in the Food Chain (CONTAM)

doi:10.2903/j.efsa.2018.5367

Risk to human and animal health related to the presence of 4,15‐diacetoxyscirpenol in food and feed

Helle Katrine Knutsen, Jan Alexander, Lars Barregård, Margherita Bignami, Beat Brüschweiler, Sandra Ceccatelli, Bruce Cottrill, Michael Dinovi, Bettina Grasl-Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Carlo Stefano Nebbia, Isabelle P. Oswald, Annette Petersen, Martin Rose, Alain-Claude Roudot, Tanja Schwerdtle, Christiane Vleminckx, Günter Vollmer, Heather WallaceSarah De Saeger, Gunnar Sundstøl Eriksen, Peter Farmer, Jean-Marc Fremy, Yun Yun Gong, Karsten Meyer, Dominique Parent-Massin, Hans van Egmond, Andrea Altieri, Paolo Colombo, Zsuzsanna Horvath, Sara Levorato, Lutz Edler, EFSA Panel on Contaminants in the Food Chain (CONTAM)

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

10 Downloads (Pure)

Abstract

4,15‐Diacetoxyscirpenol (DAS) is a mycotoxin primarily produced by Fusarium fungi and occurring predominantly in cereal grains. As requested by the European Commission, the EFSA Panel on Contaminants in the Food Chain (CONTAM) assessed the risk of DAS to human and animal health related to its presence in food and feed. Very limited information was available on toxicity and on toxicokinetics in experimental and farm animals. Due to the limitations in the available data set, human acute and chronic health‐based guidance values (HBGV) were established based on data obtained in clinical trials of DAS as an anticancer agent (anguidine) after intravenous administration to cancer patients. The CONTAM Panel considered these data as informative for the hazard characterisation of DAS after oral exposure. The main adverse effects after acute and repeated exposure were emesis, with a no‐observed‐adverse‐effect level (NOAEL) of 32 μg DAS/kg body weight (bw), and haematotoxicity, with a NOAEL of 65 μg DAS/kg bw, respectively. An acute reference dose (ARfD) of 3.2 μg DAS/kg bw and a tolerable daily intake (TDI) of 0.65 μg DAS/kg bw were established. Based on over 15,000 occurrence data, the highest acute and chronic dietary exposures were estimated to be 0.8 and 0.49 μg DAS/kg bw per day, respectively, and were not of health concern for humans. The limited information for poultry, pigs and dogs indicated a low risk for these animals at the estimated DAS exposure levels under current feeding practices, with the possible exception of fattening chicken. Assuming similar or lower sensitivity than for poultry, the risk was considered overall low for other farm and companion animal species for which no toxicity data were available. In consideration of the similarities of several trichothecenes and the likelihood of co‐exposure via food and feed, it could be appropriate to perform a cumulative risk assessment for this group of substances.

Original language	English
Article number	e05367
Number of pages	106
Journal	EFSA Journal
Volume	16
Issue number	8
Early online date	16 Aug 2018
DOIs	https://doi.org/10.2903/j.efsa.2018.5367
Publication status	Published - Aug 2018

Keywords

4,15 ‐ diacetoxyscirpenol
DAS
anguidine
MAS
exposure
toxicity
human and animal risk assessment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.2903/j.efsa.2018.5367Licence: CC BY-ND

Risk to human and animal health related to the presence of 4,15‐diacetoxyscirpenol in food and feed
© 2018 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the Creative Commons Attribution‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made. https://creativecommons.org/licenses/by-nd/4.0/
Final published version, 10.7 MBLicence: CC BY-ND

Cite this

Knutsen, H. K., Alexander, J., Barregård, L., Bignami, M., Brüschweiler, B., Ceccatelli, S., Cottrill, B., Dinovi, M., Grasl-Kraupp, B., Hogstrand, C., Hoogenboom, L., Nebbia, C. S., Oswald, I. P., Petersen, A., Rose, M., Roudot, A-C., Schwerdtle, T., Vleminckx, C., Vollmer, G., ... EFSA Panel on Contaminants in the Food Chain (CONTAM) (2018). Risk to human and animal health related to the presence of 4,15‐diacetoxyscirpenol in food and feed. EFSA Journal, 16(8), [e05367]. https://doi.org/10.2903/j.efsa.2018.5367

Knutsen, HK, Alexander, J, Barregård, L, Bignami, M, Brüschweiler, B, Ceccatelli, S, Cottrill, B, Dinovi, M, Grasl-Kraupp, B, Hogstrand, C, Hoogenboom, L, Nebbia, CS, Oswald, IP, Petersen, A, Rose, M, Roudot, A-C, Schwerdtle, T, Vleminckx, C, Vollmer, G, Wallace, H, De Saeger, S, Eriksen, GS, Farmer, P, Fremy, J-M, Gong, YY, Meyer, K, Parent-Massin, D, van Egmond, H, Altieri, A, Colombo, P, Horvath, Z, Levorato, S, Edler, L & EFSA Panel on Contaminants in the Food Chain (CONTAM) 2018, 'Risk to human and animal health related to the presence of 4,15‐diacetoxyscirpenol in food and feed', EFSA Journal, vol. 16, no. 8, e05367. https://doi.org/10.2903/j.efsa.2018.5367

@article{89051b588f1f420db292ecef8a32a4ad,

title = "Risk to human and animal health related to the presence of 4,15‐diacetoxyscirpenol in food and feed",

abstract = "4,15‐Diacetoxyscirpenol (DAS) is a mycotoxin primarily produced by Fusarium fungi and occurring predominantly in cereal grains. As requested by the European Commission, the EFSA Panel on Contaminants in the Food Chain (CONTAM) assessed the risk of DAS to human and animal health related to its presence in food and feed. Very limited information was available on toxicity and on toxicokinetics in experimental and farm animals. Due to the limitations in the available data set, human acute and chronic health‐based guidance values (HBGV) were established based on data obtained in clinical trials of DAS as an anticancer agent (anguidine) after intravenous administration to cancer patients. The CONTAM Panel considered these data as informative for the hazard characterisation of DAS after oral exposure. The main adverse effects after acute and repeated exposure were emesis, with a no‐observed‐adverse‐effect level (NOAEL) of 32 μg DAS/kg body weight (bw), and haematotoxicity, with a NOAEL of 65 μg DAS/kg bw, respectively. An acute reference dose (ARfD) of 3.2 μg DAS/kg bw and a tolerable daily intake (TDI) of 0.65 μg DAS/kg bw were established. Based on over 15,000 occurrence data, the highest acute and chronic dietary exposures were estimated to be 0.8 and 0.49 μg DAS/kg bw per day, respectively, and were not of health concern for humans. The limited information for poultry, pigs and dogs indicated a low risk for these animals at the estimated DAS exposure levels under current feeding practices, with the possible exception of fattening chicken. Assuming similar or lower sensitivity than for poultry, the risk was considered overall low for other farm and companion animal species for which no toxicity data were available. In consideration of the similarities of several trichothecenes and the likelihood of co‐exposure via food and feed, it could be appropriate to perform a cumulative risk assessment for this group of substances. ",

keywords = " 4,15 ‐ diacetoxyscirpenol, DAS, anguidine, MAS, exposure, toxicity, human and animal risk assessment",

author = "Knutsen, {Helle Katrine} and Jan Alexander and Lars Barreg{\aa}rd and Margherita Bignami and Beat Br{\"u}schweiler and Sandra Ceccatelli and Bruce Cottrill and Michael Dinovi and Bettina Grasl-Kraupp and Christer Hogstrand and Hoogenboom, {Laurentius (Ron)} and Nebbia, {Carlo Stefano} and Oswald, {Isabelle P.} and Annette Petersen and Martin Rose and Alain-Claude Roudot and Tanja Schwerdtle and Christiane Vleminckx and G{\"u}nter Vollmer and Heather Wallace and {De Saeger}, Sarah and Eriksen, {Gunnar Sundst{\o}l} and Peter Farmer and Jean-Marc Fremy and Gong, {Yun Yun} and Karsten Meyer and Dominique Parent-Massin and {van Egmond}, Hans and Andrea Altieri and Paolo Colombo and Zsuzsanna Horvath and Sara Levorato and Lutz Edler and {EFSA Panel on Contaminants in the Food Chain (CONTAM)}",

note = "The CONTAM Panel wishes to thank the hearing expert Chiara Dall'Asta, the WG member Hanspeter Naegeli and the EFSA staff member Mari Eskola for the support provided to this scientific output. The CONTAM Panel acknowledges all European competent institutions and other stakeholders that provided occurrence data on DAS in food and feed, and supported the data collection for the Comprehensive European Food Consumption database. Adopted: 29 June 2018",

year = "2018",

month = aug,

doi = "10.2903/j.efsa.2018.5367",

language = "English",

volume = "16",

journal = "EFSA Journal",

issn = "1831-4732",

publisher = "John Wiley & Sons, Ltd",

number = "8",

}

TY - JOUR

T1 - Risk to human and animal health related to the presence of 4,15‐diacetoxyscirpenol in food and feed

AU - Knutsen, Helle Katrine

AU - Alexander, Jan

AU - Barregård, Lars

AU - Bignami, Margherita

AU - Brüschweiler, Beat

AU - Ceccatelli, Sandra

AU - Cottrill, Bruce

AU - Dinovi, Michael

AU - Grasl-Kraupp, Bettina

AU - Hogstrand, Christer

AU - Hoogenboom, Laurentius (Ron)

AU - Nebbia, Carlo Stefano

AU - Oswald, Isabelle P.

AU - Petersen, Annette

AU - Rose, Martin

AU - Roudot, Alain-Claude

AU - Schwerdtle, Tanja

AU - Vleminckx, Christiane

AU - Vollmer, Günter

AU - Wallace, Heather

AU - De Saeger, Sarah

AU - Eriksen, Gunnar Sundstøl

AU - Farmer, Peter

AU - Fremy, Jean-Marc

AU - Gong, Yun Yun

AU - Meyer, Karsten

AU - Parent-Massin, Dominique

AU - van Egmond, Hans

AU - Altieri, Andrea

AU - Colombo, Paolo

AU - Horvath, Zsuzsanna

AU - Levorato, Sara

AU - Edler, Lutz

AU - EFSA Panel on Contaminants in the Food Chain (CONTAM)

N1 - The CONTAM Panel wishes to thank the hearing expert Chiara Dall'Asta, the WG member Hanspeter Naegeli and the EFSA staff member Mari Eskola for the support provided to this scientific output. The CONTAM Panel acknowledges all European competent institutions and other stakeholders that provided occurrence data on DAS in food and feed, and supported the data collection for the Comprehensive European Food Consumption database. Adopted: 29 June 2018

PY - 2018/8

Y1 - 2018/8

N2 - 4,15‐Diacetoxyscirpenol (DAS) is a mycotoxin primarily produced by Fusarium fungi and occurring predominantly in cereal grains. As requested by the European Commission, the EFSA Panel on Contaminants in the Food Chain (CONTAM) assessed the risk of DAS to human and animal health related to its presence in food and feed. Very limited information was available on toxicity and on toxicokinetics in experimental and farm animals. Due to the limitations in the available data set, human acute and chronic health‐based guidance values (HBGV) were established based on data obtained in clinical trials of DAS as an anticancer agent (anguidine) after intravenous administration to cancer patients. The CONTAM Panel considered these data as informative for the hazard characterisation of DAS after oral exposure. The main adverse effects after acute and repeated exposure were emesis, with a no‐observed‐adverse‐effect level (NOAEL) of 32 μg DAS/kg body weight (bw), and haematotoxicity, with a NOAEL of 65 μg DAS/kg bw, respectively. An acute reference dose (ARfD) of 3.2 μg DAS/kg bw and a tolerable daily intake (TDI) of 0.65 μg DAS/kg bw were established. Based on over 15,000 occurrence data, the highest acute and chronic dietary exposures were estimated to be 0.8 and 0.49 μg DAS/kg bw per day, respectively, and were not of health concern for humans. The limited information for poultry, pigs and dogs indicated a low risk for these animals at the estimated DAS exposure levels under current feeding practices, with the possible exception of fattening chicken. Assuming similar or lower sensitivity than for poultry, the risk was considered overall low for other farm and companion animal species for which no toxicity data were available. In consideration of the similarities of several trichothecenes and the likelihood of co‐exposure via food and feed, it could be appropriate to perform a cumulative risk assessment for this group of substances.

AB - 4,15‐Diacetoxyscirpenol (DAS) is a mycotoxin primarily produced by Fusarium fungi and occurring predominantly in cereal grains. As requested by the European Commission, the EFSA Panel on Contaminants in the Food Chain (CONTAM) assessed the risk of DAS to human and animal health related to its presence in food and feed. Very limited information was available on toxicity and on toxicokinetics in experimental and farm animals. Due to the limitations in the available data set, human acute and chronic health‐based guidance values (HBGV) were established based on data obtained in clinical trials of DAS as an anticancer agent (anguidine) after intravenous administration to cancer patients. The CONTAM Panel considered these data as informative for the hazard characterisation of DAS after oral exposure. The main adverse effects after acute and repeated exposure were emesis, with a no‐observed‐adverse‐effect level (NOAEL) of 32 μg DAS/kg body weight (bw), and haematotoxicity, with a NOAEL of 65 μg DAS/kg bw, respectively. An acute reference dose (ARfD) of 3.2 μg DAS/kg bw and a tolerable daily intake (TDI) of 0.65 μg DAS/kg bw were established. Based on over 15,000 occurrence data, the highest acute and chronic dietary exposures were estimated to be 0.8 and 0.49 μg DAS/kg bw per day, respectively, and were not of health concern for humans. The limited information for poultry, pigs and dogs indicated a low risk for these animals at the estimated DAS exposure levels under current feeding practices, with the possible exception of fattening chicken. Assuming similar or lower sensitivity than for poultry, the risk was considered overall low for other farm and companion animal species for which no toxicity data were available. In consideration of the similarities of several trichothecenes and the likelihood of co‐exposure via food and feed, it could be appropriate to perform a cumulative risk assessment for this group of substances.

KW - 4,15 ‐ diacetoxyscirpenol

KW - DAS

KW - anguidine

KW - MAS

KW - exposure

KW - toxicity

KW - human and animal risk assessment

U2 - 10.2903/j.efsa.2018.5367

DO - 10.2903/j.efsa.2018.5367

M3 - Article

VL - 16

JO - EFSA Journal

JF - EFSA Journal

SN - 1831-4732

IS - 8

M1 - e05367

ER -

Risk to human and animal health related to the presence of 4,15‐diacetoxyscirpenol in food and feed

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this