Role of host genes in sporadic gastric cancer

Emad Munir El-Omar

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Gastric cancer remains a major health problem particularly in the developing world. Helicobacter pylori (H. pylori) infection is the most recognised aetiological risk factor for this malignancy. The infection causes a chronic gastritis that is the precursor to all the pathophysiological abnormalities characteristic of gastric carcinogenesis. Genetic polymorphisms have emerged in recent years as important determinants of disease susceptibility and severity. In the case of H. pylori-induced gastric cancer, host genetic polymorphisms play an important role both in the precancerous stages and in the transition to cancer. In particular, polymorphic genes of the adaptive and innate immune response are involved in all stages of the neoplastic process. This field is rapidly expanding and many other genetic determinants are currently being defined. The ultimate value of host genetics should be in understanding the pathogenesis of the disease, which would offer a true opportunity to defeat this global killer.

Original languageEnglish
Pages (from-to)675-686
Number of pages12
JournalBest Practice & Research Clinical Gastroenterology
Volume20
Issue number4
DOIs
Publication statusPublished - 2006

Keywords

  • gastric cancer
  • Helicobacter pylori
  • genetic polymorphisms
  • single nucleotide polymorphisms
  • cytokines
  • interleukins
  • toll-like receptors
  • helicobacter-pylori infection
  • acid suppressive therapy
  • duodenal-ulcer disease
  • necrosis-factor-alpha
  • Toll like receptors
  • atrophic gastritis
  • increased risk
  • Chinese population
  • interleukin-1 polymorphisms
  • reflux esophagitis

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