Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: the ARCAGE study

Tatiana MacFarlane, G. J. Macfarlane, N. S. Thakker, S. Benhamou, C. Bouchardy, W. Ahrens, H. Pohlabeln, P. Lagiou, A. Lagiou, X. Castellsague, A. Agudo, A. Slamova, J. Plzak, F. Merletti, L. Richiardi, R. Talamini, L. Barzan, K. Kjaerheim, C. Canova, L. SimonatoD. I. Conway, P. A. McKinney, P. Thomson, P. Sloan, A. Znaor, C. M. Healy, B. E. McCartan, M. Marron, P. Brennan

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Abstract

Background: The study aimed to investigate the role of medical history (skin warts, Candida albicans, herpetic lesions, heartburn, regurgitation) and medication use (for heartburn; for regurgitation; aspirin) in the aetiology of upper aerodigestive tract (UADT) cancer.
Methods: A multicentre (10 European countries) case–control study [Alcohol-Related CAncers and GEnetic susceptibility (ARCAGE) project].
Results: There were 1779 cases of UADT cancer and 1993 controls. History of warts or C. albicans infection was associated with a reduced risk [odds ratio (OR) 0.80, 95% confidence interval (CI) 0.68–0.94 and OR 0.73, 95% CI 0.60–0.89, respectively] but there was no association with herpetic lesions, heartburn, regurgitation or medication for related symptoms. Regurgitation was associated with an increased risk for cancer of the oesophagus (OR 1.47, 95% CI 0.98–2.21). Regular aspirin use was not associated with risk of UADT cancer overall but was associated with a reduced risk for cancer of oesophagus (OR 0.51, 95% CI 0.28–0.96), hypopharynx (OR 0.53, 95% CI 0.28–1.02) and larynx (OR 0.74, 95% CI 0.54–1.01).
Conclusions: A history of some infections appears to be a marker for decreased risk of UADT cancer. The role of medical history and medication use varied by UADT subsites with aspirin use associated with a decreased risk of oesophageal cancer and suggestive of a decreased risk of hypopharyngeal and laryngeal cancers.
Original languageEnglish
Pages (from-to)1053-1060
Number of pages8
JournalAnnals of Oncology
Volume23
Issue number4
Early online date9 Aug 2011
DOIs
Publication statusPublished - Apr 2012

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Genetic Predisposition to Disease
Odds Ratio
Alcohols
Confidence Intervals
Heartburn
Esophageal Neoplasms
Neoplasms
Aspirin
Warts
Candida albicans
Hypopharyngeal Neoplasms
Hypopharynx
Laryngeal Neoplasms
Larynx
Infection
Skin

Keywords

  • aspirin use
  • epidemiology
  • gastroesophageal reflux
  • medical history
  • medication use
  • upper aerodigestive tract cancer

Cite this

Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe : the ARCAGE study. / MacFarlane, Tatiana; Macfarlane, G. J.; Thakker, N. S.; Benhamou, S.; Bouchardy, C.; Ahrens, W.; Pohlabeln, H.; Lagiou, P.; Lagiou, A.; Castellsague, X.; Agudo, A.; Slamova, A.; Plzak, J. ; Merletti, F.; Richiardi, L.; Talamini, R.; Barzan, L.; Kjaerheim, K.; Canova, C.; Simonato, L.; Conway, D. I. ; McKinney, P. A.; Thomson, P.; Sloan, P.; Znaor, A.; Healy, C. M.; McCartan, B. E.; Marron, M.; Brennan, P.

In: Annals of Oncology, Vol. 23, No. 4, 04.2012, p. 1053-1060.

Research output: Contribution to journalArticle

MacFarlane, T, Macfarlane, GJ, Thakker, NS, Benhamou, S, Bouchardy, C, Ahrens, W, Pohlabeln, H, Lagiou, P, Lagiou, A, Castellsague, X, Agudo, A, Slamova, A, Plzak, J, Merletti, F, Richiardi, L, Talamini, R, Barzan, L, Kjaerheim, K, Canova, C, Simonato, L, Conway, DI, McKinney, PA, Thomson, P, Sloan, P, Znaor, A, Healy, CM, McCartan, BE, Marron, M & Brennan, P 2012, 'Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: the ARCAGE study', Annals of Oncology, vol. 23, no. 4, pp. 1053-1060. https://doi.org/10.1093/annonc/mdr335
MacFarlane, Tatiana ; Macfarlane, G. J. ; Thakker, N. S. ; Benhamou, S. ; Bouchardy, C. ; Ahrens, W. ; Pohlabeln, H. ; Lagiou, P. ; Lagiou, A. ; Castellsague, X. ; Agudo, A. ; Slamova, A. ; Plzak, J. ; Merletti, F. ; Richiardi, L. ; Talamini, R. ; Barzan, L. ; Kjaerheim, K. ; Canova, C. ; Simonato, L. ; Conway, D. I. ; McKinney, P. A. ; Thomson, P. ; Sloan, P. ; Znaor, A. ; Healy, C. M. ; McCartan, B. E. ; Marron, M. ; Brennan, P. / Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe : the ARCAGE study. In: Annals of Oncology. 2012 ; Vol. 23, No. 4. pp. 1053-1060.
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abstract = "Background: The study aimed to investigate the role of medical history (skin warts, Candida albicans, herpetic lesions, heartburn, regurgitation) and medication use (for heartburn; for regurgitation; aspirin) in the aetiology of upper aerodigestive tract (UADT) cancer. Methods: A multicentre (10 European countries) case–control study [Alcohol-Related CAncers and GEnetic susceptibility (ARCAGE) project]. Results: There were 1779 cases of UADT cancer and 1993 controls. History of warts or C. albicans infection was associated with a reduced risk [odds ratio (OR) 0.80, 95{\%} confidence interval (CI) 0.68–0.94 and OR 0.73, 95{\%} CI 0.60–0.89, respectively] but there was no association with herpetic lesions, heartburn, regurgitation or medication for related symptoms. Regurgitation was associated with an increased risk for cancer of the oesophagus (OR 1.47, 95{\%} CI 0.98–2.21). Regular aspirin use was not associated with risk of UADT cancer overall but was associated with a reduced risk for cancer of oesophagus (OR 0.51, 95{\%} CI 0.28–0.96), hypopharynx (OR 0.53, 95{\%} CI 0.28–1.02) and larynx (OR 0.74, 95{\%} CI 0.54–1.01). Conclusions: A history of some infections appears to be a marker for decreased risk of UADT cancer. The role of medical history and medication use varied by UADT subsites with aspirin use associated with a decreased risk of oesophageal cancer and suggestive of a decreased risk of hypopharyngeal and laryngeal cancers.",
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author = "Tatiana MacFarlane and Macfarlane, {G. J.} and Thakker, {N. S.} and S. Benhamou and C. Bouchardy and W. Ahrens and H. Pohlabeln and P. Lagiou and A. Lagiou and X. Castellsague and A. Agudo and A. Slamova and J. Plzak and F. Merletti and L. Richiardi and R. Talamini and L. Barzan and K. Kjaerheim and C. Canova and L. Simonato and Conway, {D. I.} and McKinney, {P. A.} and P. Thomson and P. Sloan and A. Znaor and Healy, {C. M.} and McCartan, {B. E.} and M. Marron and P. Brennan",
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TY - JOUR

T1 - Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe

T2 - the ARCAGE study

AU - MacFarlane, Tatiana

AU - Macfarlane, G. J.

AU - Thakker, N. S.

AU - Benhamou, S.

AU - Bouchardy, C.

AU - Ahrens, W.

AU - Pohlabeln, H.

AU - Lagiou, P.

AU - Lagiou, A.

AU - Castellsague, X.

AU - Agudo, A.

AU - Slamova, A.

AU - Plzak, J.

AU - Merletti, F.

AU - Richiardi, L.

AU - Talamini, R.

AU - Barzan, L.

AU - Kjaerheim, K.

AU - Canova, C.

AU - Simonato, L.

AU - Conway, D. I.

AU - McKinney, P. A.

AU - Thomson, P.

AU - Sloan, P.

AU - Znaor, A.

AU - Healy, C. M.

AU - McCartan, B. E.

AU - Marron, M.

AU - Brennan, P.

PY - 2012/4

Y1 - 2012/4

N2 - Background: The study aimed to investigate the role of medical history (skin warts, Candida albicans, herpetic lesions, heartburn, regurgitation) and medication use (for heartburn; for regurgitation; aspirin) in the aetiology of upper aerodigestive tract (UADT) cancer. Methods: A multicentre (10 European countries) case–control study [Alcohol-Related CAncers and GEnetic susceptibility (ARCAGE) project]. Results: There were 1779 cases of UADT cancer and 1993 controls. History of warts or C. albicans infection was associated with a reduced risk [odds ratio (OR) 0.80, 95% confidence interval (CI) 0.68–0.94 and OR 0.73, 95% CI 0.60–0.89, respectively] but there was no association with herpetic lesions, heartburn, regurgitation or medication for related symptoms. Regurgitation was associated with an increased risk for cancer of the oesophagus (OR 1.47, 95% CI 0.98–2.21). Regular aspirin use was not associated with risk of UADT cancer overall but was associated with a reduced risk for cancer of oesophagus (OR 0.51, 95% CI 0.28–0.96), hypopharynx (OR 0.53, 95% CI 0.28–1.02) and larynx (OR 0.74, 95% CI 0.54–1.01). Conclusions: A history of some infections appears to be a marker for decreased risk of UADT cancer. The role of medical history and medication use varied by UADT subsites with aspirin use associated with a decreased risk of oesophageal cancer and suggestive of a decreased risk of hypopharyngeal and laryngeal cancers.

AB - Background: The study aimed to investigate the role of medical history (skin warts, Candida albicans, herpetic lesions, heartburn, regurgitation) and medication use (for heartburn; for regurgitation; aspirin) in the aetiology of upper aerodigestive tract (UADT) cancer. Methods: A multicentre (10 European countries) case–control study [Alcohol-Related CAncers and GEnetic susceptibility (ARCAGE) project]. Results: There were 1779 cases of UADT cancer and 1993 controls. History of warts or C. albicans infection was associated with a reduced risk [odds ratio (OR) 0.80, 95% confidence interval (CI) 0.68–0.94 and OR 0.73, 95% CI 0.60–0.89, respectively] but there was no association with herpetic lesions, heartburn, regurgitation or medication for related symptoms. Regurgitation was associated with an increased risk for cancer of the oesophagus (OR 1.47, 95% CI 0.98–2.21). Regular aspirin use was not associated with risk of UADT cancer overall but was associated with a reduced risk for cancer of oesophagus (OR 0.51, 95% CI 0.28–0.96), hypopharynx (OR 0.53, 95% CI 0.28–1.02) and larynx (OR 0.74, 95% CI 0.54–1.01). Conclusions: A history of some infections appears to be a marker for decreased risk of UADT cancer. The role of medical history and medication use varied by UADT subsites with aspirin use associated with a decreased risk of oesophageal cancer and suggestive of a decreased risk of hypopharyngeal and laryngeal cancers.

KW - aspirin use

KW - epidemiology

KW - gastroesophageal reflux

KW - medical history

KW - medication use

KW - upper aerodigestive tract cancer

U2 - 10.1093/annonc/mdr335

DO - 10.1093/annonc/mdr335

M3 - Article

VL - 23

SP - 1053

EP - 1060

JO - Annals of Oncology

JF - Annals of Oncology

SN - 0923-7534

IS - 4

ER -