Role of spontaneous and sensory orexin network dynamics in rapid locomotion initiation

Mahesh M. Karnani* (Corresponding Author), Cornelia Schöne, Edward F. Bracey, J. Antonio González, Paulius Viskaitis, Han-Tao Li, Antoine Adamantidis, Denis Burdakov

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Citations (Scopus)
1 Downloads (Pure)

Abstract

Summary Appropriate motor control is critical for normal life, and requires hypothalamic hypocretin/orexin neurons (HONs). HONs are slowly regulated by nutrients, but also display rapid (subsecond) activity fluctuations in vivo. The necessity of these activity bursts for sensorimotor control and their roles in specific phases of movement are unknown. Here we show that temporally-restricted optosilencing of spontaneous or sensory-evoked HON bursts disrupts locomotion initiation, but does not affect ongoing locomotion. Conversely, HON optostimulation initiates locomotion with subsecond delays in a frequency-dependent manner. Using 2-photon volumetric imaging of activity of >300 HONs during sensory stimulation and self-initiated locomotion, we identify several locomotion-related HON subtypes, which distinctly predict the probability of imminent locomotion initiation, display distinct sensory responses, and are differentially modulated by food deprivation. By causally linking HON bursts to locomotion initiation, these findings reveal the sensorimotor importance of rapid spontaneous and evoked fluctuations in HON ensemble activity.
Original languageEnglish
Article number101771
Number of pages17
JournalProgress in Neurobiology
Volume187
Early online date11 Feb 2020
DOIs
Publication statusPublished - Apr 2020

Keywords

  • hypothalamus
  • orexin/hypocretin neurons
  • locomotion
  • sensorimotor processing
  • ensemble imaging
  • Locomotion
  • Ensemble imaging
  • Hypothalamus
  • Sensorimotor processing

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Role of spontaneous and sensory orexin network dynamics in rapid locomotion initiation'. Together they form a unique fingerprint.

  • Cite this

    Karnani, M. M., Schöne, C., Bracey, E. F., González, J. A., Viskaitis, P., Li, H-T., Adamantidis, A., & Burdakov, D. (2020). Role of spontaneous and sensory orexin network dynamics in rapid locomotion initiation. Progress in Neurobiology, 187, [101771]. https://doi.org/10.1016/j.pneurobio.2020.101771