Role of the gut microbiota in inflammatory bowel disease pathogenesis

what have we learnt in the past 10 years?

Georgina L Hold, Megan Smith, Charlie Grange, Euan Robert Watt, Emad M. El-Omar, Indrani Mukhopadhya

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

Our understanding of the microbial involvement in inflammatory bowel disease (IBD) pathogenesis has increased exponentially over the past decade. The development of newer molecular tools for the global assessment of the gut microbiome and the identification of nucleotide-binding oligomerization domain-containing protein 2 in 2001 and other susceptibility genes for Crohn's disease in particular has led to better understanding of the aetiopathogenesis of IBD. The microbial studies have elaborated the normal composition of the gut microbiome and its perturbations in the setting of IBD. This altered microbiome or "dysbiosis" is a key player in the protracted course of inflammation in IBD. Numerous genome-wide association studies have identified further genes involved in gastrointestinal innate immunity (including polymorphisms in genes involved in autophagy: ATG16L1 and IGRM), which have helped elucidate the relationship of the local innate immunity with the adjacent luminal bacteria. These developments have also spurred the search for specific pathogens which may have a role in the metamorphosis of the gut microbiome from a symbiotic entity to a putative pathogenic one. Here we review advances in our understanding of microbial involvement in IBD pathogenesis over the past 10 years and offer insight into how this will shape our therapeutic management of the disease in the coming years.
Original languageEnglish
Pages (from-to)1192-1210
Number of pages19
JournalWorld Journal of Gastroenterology
Volume20
Issue number5
DOIs
Publication statusPublished - 7 Feb 2014

Fingerprint

Inflammatory Bowel Diseases
Innate Immunity
Dysbiosis
Genes
Genome-Wide Association Study
Microbiota
Autophagy
Disease Management
Crohn Disease
Nucleotides
Gastrointestinal Microbiome
Inflammation
Bacteria
Therapeutics

Keywords

  • inflammatory bowel disease
  • Crohn's disease
  • ulcerative colitis
  • gut microbiota
  • innate immune response
  • Probiotics
  • prebiotics
  • faecal transplant

Cite this

Role of the gut microbiota in inflammatory bowel disease pathogenesis : what have we learnt in the past 10 years? / Hold, Georgina L; Smith, Megan; Grange, Charlie; Watt, Euan Robert; El-Omar, Emad M.; Mukhopadhya, Indrani.

In: World Journal of Gastroenterology, Vol. 20, No. 5, 07.02.2014, p. 1192-1210.

Research output: Contribution to journalArticle

Hold, Georgina L ; Smith, Megan ; Grange, Charlie ; Watt, Euan Robert ; El-Omar, Emad M. ; Mukhopadhya, Indrani. / Role of the gut microbiota in inflammatory bowel disease pathogenesis : what have we learnt in the past 10 years?. In: World Journal of Gastroenterology. 2014 ; Vol. 20, No. 5. pp. 1192-1210.
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