Role of the polymorphic IL-1B, IL-1RN and TNF-A genes in distal gastric cancer in Mexico

E. Garza-Gonzalez, F. J. Bosques-Padilla, Emad Munir El-Omar, Georgina Louise Hold, R. Tijerina-Menchaca, H. J. Maldonado-Garza, G. I. Perez-Perez

Research output: Contribution to journalArticle

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Abstract

Several cytokine gene polymorphisms have been associated with increased risk of distal gastric cancer (GC) and its precursor histological markers in Caucasian, Asian and Portuguese populations although little is known about their role in other ethnic groups. Our study investigates the role of the IL-1B-31, IL-1RN and TNF-A-308 gene polymorphisms as risk factors for the development of GC in a Mexican population. We studied 278 patients who were enrolled at the Hospital Universitario Dr. Jose Eleuterio Gonzalez, Universidad Autonoma de Nuevo Leon. The subjects were divided into 2 groups. Sixty-three patients with histologically confirmed distal GC (mean age = 58.8 years, range = 22-84, F:M = 0.56), and 215 patients with no evidence of distal or proximal GC (mean age = 56.1 years, range = 18-92, F:M = 1.17). The IL-1B-31 and the TNF-A-308 polymorphisms were determined by PCR-RFLP and pyrosequencing, respectively, in all cases and controls. The VNTR polymorphism in intron 2 of the IL-1RN gene was typed by PCR in 25 cases and 201 controls. The H. pylori status was determined by histology, rapid urease test, culture and serology for non-cancer controls and by histology for the GC cases. The carriage of the proinflammatory IL-1B-31*C allele was associated with increased risk of distal GC (odds ratio [OR] = 7.63, 95% confidence interval [CI] = 1.73-46.94, p = 0.003). When cases and controls were matched by age and gender, the OR value was higher (OR = 8.05, 95 % CI = 1.8 -50.22, p = 0.001). When only H. pylori GC cases and controls were compared, the OR value was 7.8 (95% CI = 1.05-161.8, p = 0.04). No association was found between any of the other polymorphisms studied and distal GC. In this Mexican population, the 1L-1B proinflammatory genotype increases the risk of distal GC. These findings are similar to previous reports in Caucasian populations and underscore the importance of cytokine gene polymorphisms in the development of distal GC. (C) 2004 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)237-241
Number of pages5
JournalInternational Journal of Cancer
Volume114
Issue number2
Early online date11 Nov 2004
DOIs
Publication statusPublished - 20 Mar 2005

Keywords

  • helicobacter
  • gastric cancer
  • interleukin-1
  • cytokine
  • premalignant conditions
  • IL1-RN
  • TNF-A
  • Mexico
  • helicobacter pylori infection
  • increased risk
  • interleukin-1 polymorphisms
  • atrophic gastritis
  • Korean population
  • association
  • carcinoma
  • diagnosis
  • Japanese
  • ulcers

Cite this

Garza-Gonzalez, E., Bosques-Padilla, F. J., El-Omar, E. M., Hold, G. L., Tijerina-Menchaca, R., Maldonado-Garza, H. J., & Perez-Perez, G. I. (2005). Role of the polymorphic IL-1B, IL-1RN and TNF-A genes in distal gastric cancer in Mexico. International Journal of Cancer, 114(2), 237-241. https://doi.org/10.1002/ijc.20718

Role of the polymorphic IL-1B, IL-1RN and TNF-A genes in distal gastric cancer in Mexico. / Garza-Gonzalez, E.; Bosques-Padilla, F. J.; El-Omar, Emad Munir; Hold, Georgina Louise; Tijerina-Menchaca, R.; Maldonado-Garza, H. J.; Perez-Perez, G. I.

In: International Journal of Cancer, Vol. 114, No. 2, 20.03.2005, p. 237-241.

Research output: Contribution to journalArticle

Garza-Gonzalez, E, Bosques-Padilla, FJ, El-Omar, EM, Hold, GL, Tijerina-Menchaca, R, Maldonado-Garza, HJ & Perez-Perez, GI 2005, 'Role of the polymorphic IL-1B, IL-1RN and TNF-A genes in distal gastric cancer in Mexico' International Journal of Cancer, vol. 114, no. 2, pp. 237-241. https://doi.org/10.1002/ijc.20718
Garza-Gonzalez E, Bosques-Padilla FJ, El-Omar EM, Hold GL, Tijerina-Menchaca R, Maldonado-Garza HJ et al. Role of the polymorphic IL-1B, IL-1RN and TNF-A genes in distal gastric cancer in Mexico. International Journal of Cancer. 2005 Mar 20;114(2):237-241. https://doi.org/10.1002/ijc.20718
Garza-Gonzalez, E. ; Bosques-Padilla, F. J. ; El-Omar, Emad Munir ; Hold, Georgina Louise ; Tijerina-Menchaca, R. ; Maldonado-Garza, H. J. ; Perez-Perez, G. I. / Role of the polymorphic IL-1B, IL-1RN and TNF-A genes in distal gastric cancer in Mexico. In: International Journal of Cancer. 2005 ; Vol. 114, No. 2. pp. 237-241.
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abstract = "Several cytokine gene polymorphisms have been associated with increased risk of distal gastric cancer (GC) and its precursor histological markers in Caucasian, Asian and Portuguese populations although little is known about their role in other ethnic groups. Our study investigates the role of the IL-1B-31, IL-1RN and TNF-A-308 gene polymorphisms as risk factors for the development of GC in a Mexican population. We studied 278 patients who were enrolled at the Hospital Universitario Dr. Jose Eleuterio Gonzalez, Universidad Autonoma de Nuevo Leon. The subjects were divided into 2 groups. Sixty-three patients with histologically confirmed distal GC (mean age = 58.8 years, range = 22-84, F:M = 0.56), and 215 patients with no evidence of distal or proximal GC (mean age = 56.1 years, range = 18-92, F:M = 1.17). The IL-1B-31 and the TNF-A-308 polymorphisms were determined by PCR-RFLP and pyrosequencing, respectively, in all cases and controls. The VNTR polymorphism in intron 2 of the IL-1RN gene was typed by PCR in 25 cases and 201 controls. The H. pylori status was determined by histology, rapid urease test, culture and serology for non-cancer controls and by histology for the GC cases. The carriage of the proinflammatory IL-1B-31*C allele was associated with increased risk of distal GC (odds ratio [OR] = 7.63, 95{\%} confidence interval [CI] = 1.73-46.94, p = 0.003). When cases and controls were matched by age and gender, the OR value was higher (OR = 8.05, 95 {\%} CI = 1.8 -50.22, p = 0.001). When only H. pylori GC cases and controls were compared, the OR value was 7.8 (95{\%} CI = 1.05-161.8, p = 0.04). No association was found between any of the other polymorphisms studied and distal GC. In this Mexican population, the 1L-1B proinflammatory genotype increases the risk of distal GC. These findings are similar to previous reports in Caucasian populations and underscore the importance of cytokine gene polymorphisms in the development of distal GC. (C) 2004 Wiley-Liss, Inc.",
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AU - Garza-Gonzalez, E.

AU - Bosques-Padilla, F. J.

AU - El-Omar, Emad Munir

AU - Hold, Georgina Louise

AU - Tijerina-Menchaca, R.

AU - Maldonado-Garza, H. J.

AU - Perez-Perez, G. I.

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N2 - Several cytokine gene polymorphisms have been associated with increased risk of distal gastric cancer (GC) and its precursor histological markers in Caucasian, Asian and Portuguese populations although little is known about their role in other ethnic groups. Our study investigates the role of the IL-1B-31, IL-1RN and TNF-A-308 gene polymorphisms as risk factors for the development of GC in a Mexican population. We studied 278 patients who were enrolled at the Hospital Universitario Dr. Jose Eleuterio Gonzalez, Universidad Autonoma de Nuevo Leon. The subjects were divided into 2 groups. Sixty-three patients with histologically confirmed distal GC (mean age = 58.8 years, range = 22-84, F:M = 0.56), and 215 patients with no evidence of distal or proximal GC (mean age = 56.1 years, range = 18-92, F:M = 1.17). The IL-1B-31 and the TNF-A-308 polymorphisms were determined by PCR-RFLP and pyrosequencing, respectively, in all cases and controls. The VNTR polymorphism in intron 2 of the IL-1RN gene was typed by PCR in 25 cases and 201 controls. The H. pylori status was determined by histology, rapid urease test, culture and serology for non-cancer controls and by histology for the GC cases. The carriage of the proinflammatory IL-1B-31*C allele was associated with increased risk of distal GC (odds ratio [OR] = 7.63, 95% confidence interval [CI] = 1.73-46.94, p = 0.003). When cases and controls were matched by age and gender, the OR value was higher (OR = 8.05, 95 % CI = 1.8 -50.22, p = 0.001). When only H. pylori GC cases and controls were compared, the OR value was 7.8 (95% CI = 1.05-161.8, p = 0.04). No association was found between any of the other polymorphisms studied and distal GC. In this Mexican population, the 1L-1B proinflammatory genotype increases the risk of distal GC. These findings are similar to previous reports in Caucasian populations and underscore the importance of cytokine gene polymorphisms in the development of distal GC. (C) 2004 Wiley-Liss, Inc.

AB - Several cytokine gene polymorphisms have been associated with increased risk of distal gastric cancer (GC) and its precursor histological markers in Caucasian, Asian and Portuguese populations although little is known about their role in other ethnic groups. Our study investigates the role of the IL-1B-31, IL-1RN and TNF-A-308 gene polymorphisms as risk factors for the development of GC in a Mexican population. We studied 278 patients who were enrolled at the Hospital Universitario Dr. Jose Eleuterio Gonzalez, Universidad Autonoma de Nuevo Leon. The subjects were divided into 2 groups. Sixty-three patients with histologically confirmed distal GC (mean age = 58.8 years, range = 22-84, F:M = 0.56), and 215 patients with no evidence of distal or proximal GC (mean age = 56.1 years, range = 18-92, F:M = 1.17). The IL-1B-31 and the TNF-A-308 polymorphisms were determined by PCR-RFLP and pyrosequencing, respectively, in all cases and controls. The VNTR polymorphism in intron 2 of the IL-1RN gene was typed by PCR in 25 cases and 201 controls. The H. pylori status was determined by histology, rapid urease test, culture and serology for non-cancer controls and by histology for the GC cases. The carriage of the proinflammatory IL-1B-31*C allele was associated with increased risk of distal GC (odds ratio [OR] = 7.63, 95% confidence interval [CI] = 1.73-46.94, p = 0.003). When cases and controls were matched by age and gender, the OR value was higher (OR = 8.05, 95 % CI = 1.8 -50.22, p = 0.001). When only H. pylori GC cases and controls were compared, the OR value was 7.8 (95% CI = 1.05-161.8, p = 0.04). No association was found between any of the other polymorphisms studied and distal GC. In this Mexican population, the 1L-1B proinflammatory genotype increases the risk of distal GC. These findings are similar to previous reports in Caucasian populations and underscore the importance of cytokine gene polymorphisms in the development of distal GC. (C) 2004 Wiley-Liss, Inc.

KW - helicobacter

KW - gastric cancer

KW - interleukin-1

KW - cytokine

KW - premalignant conditions

KW - IL1-RN

KW - TNF-A

KW - Mexico

KW - helicobacter pylori infection

KW - increased risk

KW - interleukin-1 polymorphisms

KW - atrophic gastritis

KW - Korean population

KW - association

KW - carcinoma

KW - diagnosis

KW - Japanese

KW - ulcers

U2 - 10.1002/ijc.20718

DO - 10.1002/ijc.20718

M3 - Article

VL - 114

SP - 237

EP - 241

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

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ER -