Roles of metallothionein in cellular metabolism

J H Beattie, I Bremner

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    The metal-binding protein metallothionein (MT) is thought to play a physiological role in Zn and Cu homeostasis and may donate or sequester these essential metals on enzymes and transcription factors. However, the production of healthy MT knockout mice demonstrates that MT is not essential for survival, growth or reproduction. Nevertheless, it appears to protect against some effects of Zn deficiency and also the toxicity of heavy metals, oxidants and a wide range of stress factors. It shows notable induction during cell proliferation with marked and usually transitory nuclear localisation being observed in some different types of proliferating cells. This suggests a nuclear function for the protein during cell division, with possible modulatory effects on growth and development. Indeed, some MT knock-out mice become obese but it is not yet clear if this phenotype is caused by lack of MT. The cellular localisation and functions of MT-I and MT-II are reviewed with reference to work on genetically modified cells and animals.

    Original languageEnglish
    Title of host publicationMETAL IONS IN BIOLOGY AND MEDICINE, VOL 5
    EditorsP Collery, P Bratter, VN deBratter, L Khassanova, JC Etienne
    Place of PublicationMONTROUGE
    PublisherJohn Libbey Eurotext
    Pages117-127
    Number of pages11
    ISBN (Print)2-7420-0214-6
    Publication statusPublished - 1998
    Event5th International Symposium on Metal Ions in Biology and Medicine - NEUHERBERG
    Duration: 8 May 199810 May 1998

    Conference

    Conference5th International Symposium on Metal Ions in Biology and Medicine
    CityNEUHERBERG
    Period8/05/9810/05/98

    Keywords

    • CENTRAL-NERVOUS-SYSTEM
    • I-TRANSGENIC MICE
    • NULL MICE
    • IMMUNOHISTOCHEMICAL LOCALIZATION
    • RAT-LIVER
    • INDUCED NEPHROTOXICITY
    • INCREASED SENSITIVITY
    • ZINC-DEFICIENCY
    • GENE-EXPRESSION
    • PROTECTIVE ROLE

    Cite this

    Beattie, J. H., & Bremner, I. (1998). Roles of metallothionein in cellular metabolism. In P. Collery, P. Bratter, VN. deBratter, L. Khassanova, & JC. Etienne (Eds.), METAL IONS IN BIOLOGY AND MEDICINE, VOL 5 (pp. 117-127). MONTROUGE: John Libbey Eurotext.

    Roles of metallothionein in cellular metabolism. / Beattie, J H ; Bremner, I .

    METAL IONS IN BIOLOGY AND MEDICINE, VOL 5. ed. / P Collery; P Bratter; VN deBratter; L Khassanova; JC Etienne. MONTROUGE : John Libbey Eurotext, 1998. p. 117-127.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Beattie, JH & Bremner, I 1998, Roles of metallothionein in cellular metabolism. in P Collery, P Bratter, VN deBratter, L Khassanova & JC Etienne (eds), METAL IONS IN BIOLOGY AND MEDICINE, VOL 5. John Libbey Eurotext, MONTROUGE, pp. 117-127, 5th International Symposium on Metal Ions in Biology and Medicine, NEUHERBERG, 8/05/98.
    Beattie JH, Bremner I. Roles of metallothionein in cellular metabolism. In Collery P, Bratter P, deBratter VN, Khassanova L, Etienne JC, editors, METAL IONS IN BIOLOGY AND MEDICINE, VOL 5. MONTROUGE: John Libbey Eurotext. 1998. p. 117-127
    Beattie, J H ; Bremner, I . / Roles of metallothionein in cellular metabolism. METAL IONS IN BIOLOGY AND MEDICINE, VOL 5. editor / P Collery ; P Bratter ; VN deBratter ; L Khassanova ; JC Etienne. MONTROUGE : John Libbey Eurotext, 1998. pp. 117-127
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    abstract = "The metal-binding protein metallothionein (MT) is thought to play a physiological role in Zn and Cu homeostasis and may donate or sequester these essential metals on enzymes and transcription factors. However, the production of healthy MT knockout mice demonstrates that MT is not essential for survival, growth or reproduction. Nevertheless, it appears to protect against some effects of Zn deficiency and also the toxicity of heavy metals, oxidants and a wide range of stress factors. It shows notable induction during cell proliferation with marked and usually transitory nuclear localisation being observed in some different types of proliferating cells. This suggests a nuclear function for the protein during cell division, with possible modulatory effects on growth and development. Indeed, some MT knock-out mice become obese but it is not yet clear if this phenotype is caused by lack of MT. The cellular localisation and functions of MT-I and MT-II are reviewed with reference to work on genetically modified cells and animals.",
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    AB - The metal-binding protein metallothionein (MT) is thought to play a physiological role in Zn and Cu homeostasis and may donate or sequester these essential metals on enzymes and transcription factors. However, the production of healthy MT knockout mice demonstrates that MT is not essential for survival, growth or reproduction. Nevertheless, it appears to protect against some effects of Zn deficiency and also the toxicity of heavy metals, oxidants and a wide range of stress factors. It shows notable induction during cell proliferation with marked and usually transitory nuclear localisation being observed in some different types of proliferating cells. This suggests a nuclear function for the protein during cell division, with possible modulatory effects on growth and development. Indeed, some MT knock-out mice become obese but it is not yet clear if this phenotype is caused by lack of MT. The cellular localisation and functions of MT-I and MT-II are reviewed with reference to work on genetically modified cells and animals.

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    KW - NULL MICE

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    KW - INDUCED NEPHROTOXICITY

    KW - INCREASED SENSITIVITY

    KW - ZINC-DEFICIENCY

    KW - GENE-EXPRESSION

    KW - PROTECTIVE ROLE

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    EP - 127

    BT - METAL IONS IN BIOLOGY AND MEDICINE, VOL 5

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    A2 - Bratter, P

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