Rotavirus gastroenteritis and central nervous system (CNS) infection: characterization of the VP7 and VP4 genes of rotavirus strains isolated from paired fecal and cerebrospinal fluid samples from a child with CNS disease

M. Iturriza-Gomara, Ian A Auchterlonie, Win Zaw, P. Molyneaux, U. Desselberger, J. Gray

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    Abstract

    Rotavirus RNA was detected in the cerebrospinal fluid (CSF) of a child with central nervous system disease symptoms associated with rotavirus gastroenteritis. The rotavirus isolates from the fecal and CSF samples were genotyped as G1P[8]. Sequence analysis of the VP7 and VP4 proteins derived from the fecal and CSF samples were remarkably similar to each other and to G1P[8] rotavirus strains commonly circulating in the community and associated with gastroenteritis.

    Original languageEnglish
    Pages (from-to)4797-4799
    Number of pages2
    JournalJournal of Clinical Microbiology
    Volume40
    Issue number12
    DOIs
    Publication statusPublished - 2002

    Keywords

    • POLYMERASE-CHAIN-REACTION
    • REVERSE TRANSCRIPTION
    • ENCEPHALOPATHY
    • ENCEPHALITIS
    • CONVULSIONS
    • DIVERSITY
    • SYMPTOMS
    • NEURONS
    • AXONS
    • PCR

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