Rotavirus infection in children with acute gastroenteritis in Iran

A systematic review and meta-analysis

Maziar Moradi-Lakeh, Sareh Shakerian*, Mohsen Yaghoubi, Abdoulreza Esteghamati, Frahad Shokraneh, Hamid Reza Baradaran, Roxana Mansour Ghanaee

*Corresponding author for this work

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Background: The recent studies show that Rotavirus is important cause of the acute gastroenteritis. The aim of this review is to estimate the number of Rotavirus infection among Iranian children by performing a systematic review and estimating a pooled data.

Methods: We performed a systematic literature review in relevant databases including PUBMED, MEDLINE, OVID, SID, MAGIRAN, and IRANMEDEX. Search in databases was done in October 10, 2013. Meta-analysis was performed using the STATA statistical package version 11. We assessed heterogeneity by Q-test and used random model for pooling measures of proportion of Rotavirus infection among Iranian children with diarrhea (and 95% confidence intervals [CI]). Sub group analysis between in-patient and outpatient group were done and publication bias was assessed by Egger and Begg tests.

Results: A total of 154 records were identified in our searching. There were 36 studies including a total of 15,368 children with diarrhea. Out of 15,368 children, 6,338 were positive for Rotavirus gastroenteritis. Overall pooled estimate of infection with Rotavirus among cases of gastroenteritis was 0.35 (95% CI, 0.28-0.41). Pooled estimates for hospitalized children and outpatient subgroups were 0.39 (95% CI, 0.30-0.48), and 0.31 (95% CI, 0.23-0.38), respectively.

Conclusions: This study supports the importance of Rotavirus in the Iranian population such as common cause of diarrhea among children. Therefore, decision to adopt immunization programs to prevent Rotavirus infection might be helpful in Iran.

Original languageEnglish
Pages (from-to)1213-1223
Number of pages11
JournalInternational Journal of Preventive Medicine
Volume5
Issue number10
Publication statusPublished - 1 Jan 2014

Fingerprint

Rotavirus Infections
Gastroenteritis
Iran
Meta-Analysis
Rotavirus
Confidence Intervals
Diarrhea
Outpatients
Databases
Publication Bias
Immunization Programs
Hospitalized Child
Sudden Infant Death
PubMed
MEDLINE
Population

Keywords

  • Acute gastroenteritis
  • And diarrhea
  • Children
  • Rotavirus infection

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Moradi-Lakeh, M., Shakerian, S., Yaghoubi, M., Esteghamati, A., Shokraneh, F., Baradaran, H. R., & Ghanaee, R. M. (2014). Rotavirus infection in children with acute gastroenteritis in Iran: A systematic review and meta-analysis. International Journal of Preventive Medicine, 5(10), 1213-1223.

Rotavirus infection in children with acute gastroenteritis in Iran : A systematic review and meta-analysis. / Moradi-Lakeh, Maziar; Shakerian, Sareh; Yaghoubi, Mohsen; Esteghamati, Abdoulreza; Shokraneh, Frahad; Baradaran, Hamid Reza; Ghanaee, Roxana Mansour.

In: International Journal of Preventive Medicine, Vol. 5, No. 10, 01.01.2014, p. 1213-1223.

Research output: Contribution to journalReview article

Moradi-Lakeh, M, Shakerian, S, Yaghoubi, M, Esteghamati, A, Shokraneh, F, Baradaran, HR & Ghanaee, RM 2014, 'Rotavirus infection in children with acute gastroenteritis in Iran: A systematic review and meta-analysis', International Journal of Preventive Medicine, vol. 5, no. 10, pp. 1213-1223.
Moradi-Lakeh, Maziar ; Shakerian, Sareh ; Yaghoubi, Mohsen ; Esteghamati, Abdoulreza ; Shokraneh, Frahad ; Baradaran, Hamid Reza ; Ghanaee, Roxana Mansour. / Rotavirus infection in children with acute gastroenteritis in Iran : A systematic review and meta-analysis. In: International Journal of Preventive Medicine. 2014 ; Vol. 5, No. 10. pp. 1213-1223.
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abstract = "Background: The recent studies show that Rotavirus is important cause of the acute gastroenteritis. The aim of this review is to estimate the number of Rotavirus infection among Iranian children by performing a systematic review and estimating a pooled data.Methods: We performed a systematic literature review in relevant databases including PUBMED, MEDLINE, OVID, SID, MAGIRAN, and IRANMEDEX. Search in databases was done in October 10, 2013. Meta-analysis was performed using the STATA statistical package version 11. We assessed heterogeneity by Q-test and used random model for pooling measures of proportion of Rotavirus infection among Iranian children with diarrhea (and 95{\%} confidence intervals [CI]). Sub group analysis between in-patient and outpatient group were done and publication bias was assessed by Egger and Begg tests.Results: A total of 154 records were identified in our searching. There were 36 studies including a total of 15,368 children with diarrhea. Out of 15,368 children, 6,338 were positive for Rotavirus gastroenteritis. Overall pooled estimate of infection with Rotavirus among cases of gastroenteritis was 0.35 (95{\%} CI, 0.28-0.41). Pooled estimates for hospitalized children and outpatient subgroups were 0.39 (95{\%} CI, 0.30-0.48), and 0.31 (95{\%} CI, 0.23-0.38), respectively.Conclusions: This study supports the importance of Rotavirus in the Iranian population such as common cause of diarrhea among children. Therefore, decision to adopt immunization programs to prevent Rotavirus infection might be helpful in Iran.",
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