Safeguarding Female Reproductive Health against Endocrine Disrupting Chemicals: The FREIA Project

Majorie B.M. van Duursen*, Julie Boberg, Sofie Christiansen, Lisa Connolly, Pauliina Damdimopoulou, Panagiotis Filis, Paul A. Fowler , Bart M. Gadella, Jan Holte, Kersti Jääger, Hanna K.L. Johansson, Tianyi Li, Séverine Mazaud-Guittot, Anne-Simone Parent, Andres Salumets, Ana M. Soto, Terje Svingen, Agne Velthut-Meikas, Eva Bay Wedebye, Yuling XieMartin van den Berg

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Downloads (Pure)

Abstract

Currently available test methods are not well-suited for the identification of chemicals that disturb hormonal processes involved in female reproductive development and function. This renders women’s reproductive health at increasing risk globally, which, coupled with increasing incidence rates of reproductive disorders, is of great concern. A woman’s reproductive health is largely established during embryonic and fetal development and subsequently matures during puberty. The endocrine system influences development, maturation, and function of the female reproductive system, thereby making appropriate hormone levels imperative for correct functioning of reproductive processes. It is concerning that the effects of human-made chemicals on the endocrine system and female reproductive health are poorly addressed in regulatory chemical safety assessment, partly because adequate test methods are lacking. Our EU-funded project FREIA aims to address this need by increasing understanding of how endocrine disrupting chemicals (EDCs) can impact female reproductive health. We will use this information to provide better test methods that enable fit-for-purpose chemical regulation and then share our knowledge, promote a sustainable society, and improve the reproductive health of women globally.
Original languageEnglish
Article number3215
Number of pages13
Journal International Journal of Molecular Sciences
Volume21
Issue number9
Early online date1 May 2020
DOIs
Publication statusPublished - May 2020

Keywords

  • female reproductive health
  • endocrine disrupting chemicals
  • test methods
  • risk assessment
  • fertility
  • ovary
  • oocyte
  • adrenal
  • mammary gland
  • steroidogenesis
  • bioassay

Fingerprint Dive into the research topics of 'Safeguarding Female Reproductive Health against Endocrine Disrupting Chemicals: The FREIA Project'. Together they form a unique fingerprint.

  • Equipment

    Iain Fraser Cytometry Centre

    Andrea Holme (Manager), Linda Duncan (Senior Application Scientist), Ailsa Laird (Technician) & Kate Burgoyne (Technician)

    Institute of Medical Sciences

    Research Facilities: Facility

  • Cite this

    van Duursen, M. B. M., Boberg, J., Christiansen, S., Connolly, L., Damdimopoulou, P., Filis, P., Fowler , P. A., Gadella, B. M., Holte, J., Jääger, K., Johansson, H. K. L., Li, T., Mazaud-Guittot, S., Parent, A-S., Salumets, A., Soto, A. M., Svingen, T., Velthut-Meikas, A., Wedebye, E. B., ... van den Berg, M. (2020). Safeguarding Female Reproductive Health against Endocrine Disrupting Chemicals: The FREIA Project. International Journal of Molecular Sciences, 21(9), [3215]. https://doi.org/10.3390/ijms21093215