Safety of phenylcapsaicin as a novel food pursuant to Regulation (EU) 2015/2283

EFSA Panel on Nutrition, Novel Foods and Food Allergens (EFSA NDA Panel)

Research output: Contribution to journalArticle

Abstract

Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on phenylcapsaicin as a novel food (NF) pursuant to Regulation (EU) 2015/2283. Phenylcapsaicin is a chemically synthesised analogue of capsaicin intended to be marketed in food supplements and in foods for special medical purposes to the general population above the age of 11 years old at a maximum level of 2.5 mg/day. The highest intake of the NF is 2.5 mg/day which corresponds to 36 μg/kg body weight (bw) per day for adults, and 58 μg/kg bw per day for adolescents (10-14 years). The Panel considers that there is no concern with respect to genotoxicity of the NF. The reference point derived based on a 13-week rat study was the lowest of the model averaged BMDL 20 values of 37.2 mg/kg bw per day in females for increased plasma alanine aminotransferase (ALAT) levels. The Panel concludes that the NF, phenylcapsaicin, is safe under the proposed uses and use levels.

Original languageEnglish
Article numbere05718
Number of pages24
JournalEFSA Journal
Volume17
Issue number6
Early online date14 Jun 2019
DOIs
Publication statusE-pub ahead of print - 14 Jun 2019

Keywords

  • phenylcapsaicin
  • novel food
  • ingredient
  • safety

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    EFSA Panel on Nutrition, Novel Foods and Food Allergens (EFSA NDA Panel) (2019). Safety of phenylcapsaicin as a novel food pursuant to Regulation (EU) 2015/2283. EFSA Journal, 17(6), [e05718]. https://doi.org/10.2903/j.efsa.2019.5718