TY - GEN
T1 - Safety of the proposed amendment of the specifications for steviol glycosides (E 960) as a food additive
T2 - Rebaudioside M produced via enzyme-catalysed bioconversion of purified stevia leaf extract
AU - Younes, Maged
AU - Aquilina, Gabriele
AU - Engel, Karl-Heinz
AU - Fowler, Paul
AU - Frutos Fernandez, Maria Jose
AU - Fürst, Peter
AU - Gürtler, Rainer
AU - Gundert-Remy, Ursula
AU - Husøy, Trine
AU - Mennes, Wim
AU - Moldeus, Peter
AU - Oskarsson, Agneta
AU - Shah, Romina
AU - Waalkens-Berendsen, Ine
AU - Wölfle, Detlef
AU - Degen, Gisela
AU - Gott, David
AU - Leblanc, Jean-Charles
AU - Herman, Lieve
AU - Aguilera, Jaime
AU - Giarola, Alessandra
AU - Rincon, Ana M
AU - Castle, Laurence
AU - EFSA Panel on Food Additives and Flavourings (FAF)
PY - 2019/10
Y1 - 2019/10
N2 - Abstract The EFSA Panel on Food Additives and Flavourings (FAF) provides a scientific opinion on the safety of the proposed amendment of the specifications for steviol glycosides (E 960) as a food additive, in particular related to rebaudioside M produced via enzyme-catalysed bioconversion of purified stevia leaf extract. Rebaudioside M (95 is produced via enzymatic bioconversion of purified stevia leaf extract using uridine diphosphate (UDP)-glucosyltransferase and sucrose synthase enzymes produced by the genetically modified yeasts K. phaffii UGT-a and K. phaffii UGT-b, that facilitates the transfer of glucose to purified stevia leaf extract via glycosidic bonds. The Panel considered that the parental strain K. phaffii ATCC 20864 qualifies for the qualified presumption of safety (QPS) approach for safety assessment and, therefore, is considered to be safe for production purposes. The Panel concluded that there is no safety concern for Rebaudioside M produced via enzymatic bioconversion of purified stevia leaf extract using UDP-glucosyltransferase and sucrose synthase enzymes produced by the genetically modified yeasts K. phaffii UGT-a and K. phaffii UGT-b, to be used as a food additive. However, the Panel recommended that the European Commission considers establishing separate specifications for Rebaudioside M produced via enzymatic bioconversion of purified stevia leaf extract in Commission Regulation (EU) No 231/2012.
AB - Abstract The EFSA Panel on Food Additives and Flavourings (FAF) provides a scientific opinion on the safety of the proposed amendment of the specifications for steviol glycosides (E 960) as a food additive, in particular related to rebaudioside M produced via enzyme-catalysed bioconversion of purified stevia leaf extract. Rebaudioside M (95 is produced via enzymatic bioconversion of purified stevia leaf extract using uridine diphosphate (UDP)-glucosyltransferase and sucrose synthase enzymes produced by the genetically modified yeasts K. phaffii UGT-a and K. phaffii UGT-b, that facilitates the transfer of glucose to purified stevia leaf extract via glycosidic bonds. The Panel considered that the parental strain K. phaffii ATCC 20864 qualifies for the qualified presumption of safety (QPS) approach for safety assessment and, therefore, is considered to be safe for production purposes. The Panel concluded that there is no safety concern for Rebaudioside M produced via enzymatic bioconversion of purified stevia leaf extract using UDP-glucosyltransferase and sucrose synthase enzymes produced by the genetically modified yeasts K. phaffii UGT-a and K. phaffii UGT-b, to be used as a food additive. However, the Panel recommended that the European Commission considers establishing separate specifications for Rebaudioside M produced via enzymatic bioconversion of purified stevia leaf extract in Commission Regulation (EU) No 231/2012.
U2 - 10.2903/j.efsa.2019.5867
DO - 10.2903/j.efsa.2019.5867
M3 - Article
C2 - 32626146
SN - 1831-4732
VL - 17
SP - e05867
JO - EFSA Journal
JF - EFSA Journal
ER -