Safety versus success in elective single embryo transfer: Women's preferences for outcome of in vitro fertilisation

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Abstract

Objective To assess whether women waiting to undergo in vitro fertilisation (IVF) view adverse outcomes associated with twin pregnancy as more desirable than having no pregnancy at all.

Design Women's preference values for five adverse birth outcomes associated with twin pregnancy were compared with their preference value for treatment failure (TF), i.e. no pregnancy at all.

Setting Aberdeen Fertility Centre, University of Aberdeen, UK.

Population A total of 74 women waiting to undergo IVF.

Methods The standard gamble method was used to elicit women's preference values for giving birth to a child with physical impairments (PI), cognitive impairments (CI), or visual impairments (VI), perinatal death (PD) without a subsequent pregnancy, premature delivery (PremD), and TF (no pregnancy).

Main outcome measures Preference values were elicited on a scale where 1 represents giving birth to a healthy child and 0 represents immediate death.

Results The median preference values for having a child with PI, CI, or VI were 0.940, 0.970, and 0.975, respectively. The median values for PremD, PD, and TF were 0.955, 0.725, and 0.815, respectively. Having no child at all was valued significantly lower than having a child with PI, CI, or VI (P < 0.01) but significantly higher than PD (P < 0.01).

Conclusions Some women waiting for IVF treatment view severe child disability outcomes associated with double embryo transfer as being more desirable than having no child at all. Women embarking on IVF may be influenced more strongly by considerations of 'treatment success' rather than future risks to their offspring.

Original languageEnglish
Pages (from-to)977-983
Number of pages7
JournalBJOG-An International Journal of Obstetrics and Gynaecology
Volume114
Issue number8
Early online date18 Jun 2007
DOIs
Publication statusPublished - Aug 2007

Keywords

  • IVF
  • multiple pregnancy
  • patient preferences
  • single embryo transfer
  • health-care professionals
  • multiple births
  • attitudes
  • IVF/ICSI
  • pregnancies
  • infertile
  • couples
  • mothers
  • desire

Cite this

@article{05076447fedd4254a9e128c3ec0045b1,
title = "Safety versus success in elective single embryo transfer: Women's preferences for outcome of in vitro fertilisation",
abstract = "Objective To assess whether women waiting to undergo in vitro fertilisation (IVF) view adverse outcomes associated with twin pregnancy as more desirable than having no pregnancy at all. Design Women's preference values for five adverse birth outcomes associated with twin pregnancy were compared with their preference value for treatment failure (TF), i.e. no pregnancy at all. Setting Aberdeen Fertility Centre, University of Aberdeen, UK. Population A total of 74 women waiting to undergo IVF. Methods The standard gamble method was used to elicit women's preference values for giving birth to a child with physical impairments (PI), cognitive impairments (CI), or visual impairments (VI), perinatal death (PD) without a subsequent pregnancy, premature delivery (PremD), and TF (no pregnancy). Main outcome measures Preference values were elicited on a scale where 1 represents giving birth to a healthy child and 0 represents immediate death. Results The median preference values for having a child with PI, CI, or VI were 0.940, 0.970, and 0.975, respectively. The median values for PremD, PD, and TF were 0.955, 0.725, and 0.815, respectively. Having no child at all was valued significantly lower than having a child with PI, CI, or VI (P < 0.01) but significantly higher than PD (P < 0.01). Conclusions Some women waiting for IVF treatment view severe child disability outcomes associated with double embryo transfer as being more desirable than having no child at all. Women embarking on IVF may be influenced more strongly by considerations of 'treatment success' rather than future risks to their offspring.",
keywords = "IVF, multiple pregnancy, patient preferences, single embryo transfer, health-care professionals, multiple births, attitudes, IVF/ICSI, pregnancies, infertile, couples, mothers, desire",
author = "Scotland, {Graham Stewart} and Paul McNamee and Valerie Peddie and Siladitya Bhattacharya",
year = "2007",
month = "8",
doi = "10.1111/J.1471-0528.2007.01396.X",
language = "English",
volume = "114",
pages = "977--983",
journal = "BJOG-An International Journal of Obstetrics and Gynaecology",
issn = "1470-0328",
publisher = "John Wiley & Sons, Ltd (10.1111)",
number = "8",

}

TY - JOUR

T1 - Safety versus success in elective single embryo transfer

T2 - Women's preferences for outcome of in vitro fertilisation

AU - Scotland, Graham Stewart

AU - McNamee, Paul

AU - Peddie, Valerie

AU - Bhattacharya, Siladitya

PY - 2007/8

Y1 - 2007/8

N2 - Objective To assess whether women waiting to undergo in vitro fertilisation (IVF) view adverse outcomes associated with twin pregnancy as more desirable than having no pregnancy at all. Design Women's preference values for five adverse birth outcomes associated with twin pregnancy were compared with their preference value for treatment failure (TF), i.e. no pregnancy at all. Setting Aberdeen Fertility Centre, University of Aberdeen, UK. Population A total of 74 women waiting to undergo IVF. Methods The standard gamble method was used to elicit women's preference values for giving birth to a child with physical impairments (PI), cognitive impairments (CI), or visual impairments (VI), perinatal death (PD) without a subsequent pregnancy, premature delivery (PremD), and TF (no pregnancy). Main outcome measures Preference values were elicited on a scale where 1 represents giving birth to a healthy child and 0 represents immediate death. Results The median preference values for having a child with PI, CI, or VI were 0.940, 0.970, and 0.975, respectively. The median values for PremD, PD, and TF were 0.955, 0.725, and 0.815, respectively. Having no child at all was valued significantly lower than having a child with PI, CI, or VI (P < 0.01) but significantly higher than PD (P < 0.01). Conclusions Some women waiting for IVF treatment view severe child disability outcomes associated with double embryo transfer as being more desirable than having no child at all. Women embarking on IVF may be influenced more strongly by considerations of 'treatment success' rather than future risks to their offspring.

AB - Objective To assess whether women waiting to undergo in vitro fertilisation (IVF) view adverse outcomes associated with twin pregnancy as more desirable than having no pregnancy at all. Design Women's preference values for five adverse birth outcomes associated with twin pregnancy were compared with their preference value for treatment failure (TF), i.e. no pregnancy at all. Setting Aberdeen Fertility Centre, University of Aberdeen, UK. Population A total of 74 women waiting to undergo IVF. Methods The standard gamble method was used to elicit women's preference values for giving birth to a child with physical impairments (PI), cognitive impairments (CI), or visual impairments (VI), perinatal death (PD) without a subsequent pregnancy, premature delivery (PremD), and TF (no pregnancy). Main outcome measures Preference values were elicited on a scale where 1 represents giving birth to a healthy child and 0 represents immediate death. Results The median preference values for having a child with PI, CI, or VI were 0.940, 0.970, and 0.975, respectively. The median values for PremD, PD, and TF were 0.955, 0.725, and 0.815, respectively. Having no child at all was valued significantly lower than having a child with PI, CI, or VI (P < 0.01) but significantly higher than PD (P < 0.01). Conclusions Some women waiting for IVF treatment view severe child disability outcomes associated with double embryo transfer as being more desirable than having no child at all. Women embarking on IVF may be influenced more strongly by considerations of 'treatment success' rather than future risks to their offspring.

KW - IVF

KW - multiple pregnancy

KW - patient preferences

KW - single embryo transfer

KW - health-care professionals

KW - multiple births

KW - attitudes

KW - IVF/ICSI

KW - pregnancies

KW - infertile

KW - couples

KW - mothers

KW - desire

U2 - 10.1111/J.1471-0528.2007.01396.X

DO - 10.1111/J.1471-0528.2007.01396.X

M3 - Article

VL - 114

SP - 977

EP - 983

JO - BJOG-An International Journal of Obstetrics and Gynaecology

JF - BJOG-An International Journal of Obstetrics and Gynaecology

SN - 1470-0328

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ER -