Sample size calculator for cluster randomized trials

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

Cluster randomized trials, where individuals are randomized in groups are increasingly being used in healthcare evaluation. The adoption of a clustered design has implications for design, conduct and analysis of studies. In particular, standard sample sizes have to be inflated for cluster designs, as outcomes for individuals within clusters may be correlated; inflation can be achieved either by increasing the cluster size or by increasing the number of clusters in the study. A sample size calculator is presented for calculating appropriate sample sizes for cluster trials, whilst allowing the implications of both methods of inflation to be considered. (C) 2003 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)113-125
Number of pages12
JournalComputers in Biology and Medicine
Volume34
Issue number2
DOIs
Publication statusPublished - 2004

Keywords

  • cluster randomized trial
  • sample size
  • calculator
  • inflation factor
  • BINARY
  • CARE

Cite this

Sample size calculator for cluster randomized trials. / Campbell, Marion Kay; Thomson, S.; Ramsay, Craig R; MacLennan, Graeme Stewart.

In: Computers in Biology and Medicine, Vol. 34, No. 2, 2004, p. 113-125.

Research output: Contribution to journalArticle

@article{4bc00289e2f04552b7f90d70e5257467,
title = "Sample size calculator for cluster randomized trials",
abstract = "Cluster randomized trials, where individuals are randomized in groups are increasingly being used in healthcare evaluation. The adoption of a clustered design has implications for design, conduct and analysis of studies. In particular, standard sample sizes have to be inflated for cluster designs, as outcomes for individuals within clusters may be correlated; inflation can be achieved either by increasing the cluster size or by increasing the number of clusters in the study. A sample size calculator is presented for calculating appropriate sample sizes for cluster trials, whilst allowing the implications of both methods of inflation to be considered. (C) 2003 Elsevier Ltd. All rights reserved.",
keywords = "cluster randomized trial, sample size, calculator, inflation factor, BINARY, CARE",
author = "Campbell, {Marion Kay} and S. Thomson and Ramsay, {Craig R} and MacLennan, {Graeme Stewart}",
year = "2004",
doi = "10.1016/S0010-4825(03)00039-8",
language = "English",
volume = "34",
pages = "113--125",
journal = "Computers in Biology and Medicine",
issn = "0010-4825",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Sample size calculator for cluster randomized trials

AU - Campbell, Marion Kay

AU - Thomson, S.

AU - Ramsay, Craig R

AU - MacLennan, Graeme Stewart

PY - 2004

Y1 - 2004

N2 - Cluster randomized trials, where individuals are randomized in groups are increasingly being used in healthcare evaluation. The adoption of a clustered design has implications for design, conduct and analysis of studies. In particular, standard sample sizes have to be inflated for cluster designs, as outcomes for individuals within clusters may be correlated; inflation can be achieved either by increasing the cluster size or by increasing the number of clusters in the study. A sample size calculator is presented for calculating appropriate sample sizes for cluster trials, whilst allowing the implications of both methods of inflation to be considered. (C) 2003 Elsevier Ltd. All rights reserved.

AB - Cluster randomized trials, where individuals are randomized in groups are increasingly being used in healthcare evaluation. The adoption of a clustered design has implications for design, conduct and analysis of studies. In particular, standard sample sizes have to be inflated for cluster designs, as outcomes for individuals within clusters may be correlated; inflation can be achieved either by increasing the cluster size or by increasing the number of clusters in the study. A sample size calculator is presented for calculating appropriate sample sizes for cluster trials, whilst allowing the implications of both methods of inflation to be considered. (C) 2003 Elsevier Ltd. All rights reserved.

KW - cluster randomized trial

KW - sample size

KW - calculator

KW - inflation factor

KW - BINARY

KW - CARE

U2 - 10.1016/S0010-4825(03)00039-8

DO - 10.1016/S0010-4825(03)00039-8

M3 - Article

VL - 34

SP - 113

EP - 125

JO - Computers in Biology and Medicine

JF - Computers in Biology and Medicine

SN - 0010-4825

IS - 2

ER -