Sample size

How many patients are necessary?

P. M. Fayers*, D. Machin

*Corresponding author for this work

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The need for sample size calculations is briefly reviewed: Many of the arguments against small trials are already well known, and we only cursorily repeat them in passing. Problems that arise in the estimation of sample size are then discussed, with particular reference to survival studies. However, most of the issues which we discuss are equally applicable to other types of study. Finally, prognostic factor analysis designs are discussed, since this is another area in which experience shows that far too many studies are of an inadequate size and yield misleading results.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalBritish Journal of Cancer
Volume72
Issue number1
DOIs
Publication statusPublished - 1 Jan 1995

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Sample Size
Statistical Factor Analysis
Survival

Keywords

  • Number of patients
  • Power calulation
  • Randomised trials
  • Sample size
  • Study size

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Sample size : How many patients are necessary? / Fayers, P. M.; Machin, D.

In: British Journal of Cancer, Vol. 72, No. 1, 01.01.1995, p. 1-9.

Research output: Contribution to journalArticle

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