Scanning Conditions in Functional Connectivity Magnetic Resonance Imaging: How to Standardise Resting-State for Optimal Data Acquisition and Visualisation?

Catarina Dinis Fernandes* (Corresponding Author), Ourania Varsou, Michael Stringer, Mary Joan Macleod, Christian Schwarzbauer

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Functional connectivity magnetic resonance imaging (fcMRI), performed during resting wakefulness without tasks or stimulation, is a non-invasive technique to assess and visualise functional brain networks in vivo. Acquisition of resting-state imaging data has become increasingly common in longitudinal studies to investigate brain health and disease. However, the scanning protocols vary considerably across different institutions creating challenges for comparability especially for the interpretation of findings in patient cohorts and establishment of diagnostic or prognostic imaging biomarkers. The aim of this chapter is to discuss the effect of two experimental conditions (i.e. a low cognitive demand paradigm and a pure resting-state fcMRI) on the reproducibility of brain networks between a baseline and a follow-up session, 30 (±5) days later, acquired from 12 right-handed volunteers (29 ± 5 yrs). A novel method was developed and used for a direct statistical comparison of the test-retest reliability using 28 well-established functional brain networks. Overall, both scanning conditions produced good levels of test-retest reliability. While the pure resting-state condition showed higher test-retest reliability for 18 of the 28 analysed networks, the low cognitive demand paradigm produced higher test-retest reliability for 8 of the 28 brain networks (i.e. visual, sensorimotor and frontal areas); in 2 of the 28 brain networks no significant changes could be detected. These results are relevant to planning of longitudinal studies, as higher test-retest reliability generally increases statistical power. This work also makes an important contribution to neuroimaging where optimising fcMRI experimental scanning conditions, and hence data visualisation of brain function, remains an on-going topic of interest. In this chapter, we provide a full methodological explanation of the two paradigms and our analysis so that readers can apply them to their own scanning protocols.
Original languageEnglish
Title of host publicationBiomedical Visualisation
EditorsPaul M. Rea
PublisherSpringer
Chapter3
Pages35-52
Number of pages18
Volume6
ISBN (Electronic)9783030376390
ISBN (Print)9783030376383
DOIs
Publication statusPublished - 2020

Publication series

NameAdvances in Experimental Medicine and Biology (AEMB)
PublisherSpringer
Volume1235
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • brain
  • magnetic resonance imaging
  • functional connectivity
  • resting-state
  • Functional connectivity
  • Brain
  • Magnetic resonance imaging
  • Resting-state
  • NETWORK
  • HUMAN BRAIN
  • MRI
  • DEFAULT MODE
  • REPRODUCIBILITY
  • IMPACT
  • ARCHITECTURE
  • EYES OPEN
  • TEST-RETEST RELIABILITY
  • FMRI

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