Screening seeds of some Scottish plants for free radical scavenging activity

Yashodharan Kumarasamy, Maureen Byres, Philip J. Cox, Marcel Jaspars, Lutfun Nahar, Satyajit D. Sarker

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From a consideration of ethnobotanical and taxonomic information, seeds of 45 Scottish plant species encompassing 23 different families were obtained from authentic seed suppliers. The n-hexane, dichloromethane (DCM) and methanol (MeOH) extracts were assessed, both qualitatively and quantitatively, for free radical scavenging activity in the DPPH assay. The MeOH extracts of 37 species exhibited low to high levels of free radical scavenging activity (RC,, values ranging from 2.00 to 4.7 x 10(-4) mg/mL), and Alliaria petiolata, Prunus padus and Prunus spinosa were the most potent antioxidant extracts. The DCM extracts of 17 species showed similar levels of activity, and among those, Prunus padus and Prunus spinosa extracts were the most active with RC,, values of 2.5 x 10(-4) and 5.0 x 10-4 mg/mL, respectively. The n-hexane extracts were much less active than the MeOH and DCM extracts, and 17 species, with the exception of Glechoma hederacea (RC50 = 1.94 x 10(-4)) displayed low to moderate levels of free radical scavenging property (RC50 values ranging from 2.00 to 8.7 x 10(-3) mg/mL). Copyright (C) 2007 John Wiley & Sons, Ltd.

Original languageEnglish
Pages (from-to)615-621
Number of pages7
JournalPhytotherapy Research
Issue number7
Early online date14 Mar 2007
Publication statusPublished - Jul 2007


  • scottish plants
  • antioxidant activity
  • DPPH assay
  • free radical scavenger
  • amyotrophic-lateral-sclerosis
  • oxidative stress
  • reactive oxygen
  • Alzheimers-disease
  • mechanism
  • protein
  • cells
  • antioxidants
  • progression
  • hypothesis

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