SEARCH international case-control study of childhood brain tumours

Role of index pregnancy and birth, and mother's reproductive history

Margaret McCredie*, Julian Little, Seonaidh Cotton, Beth Mueller, Raphael Peris-Bonet, N. W. Choi, Sylvaine Cordier, Graziella Filippini, Elizabeth A. Holly, Baruch Modan, Annie Arslan, Susan Preston-Martin

*Corresponding author for this work

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

A series of co-ordinated population-based case-control studies of childhood brain tumours (CBT) was undertaken under the auspices of the Surveillance of Environmental Aspects Related to Cancer in Humans (SEARCH) programme of the International Agency for Research on Cancer (IARC) to evaluate, inter alia, the risk in relation to characteristics of the index pregnancy and birth, and maternal reproductive history. Subjects comprised 1218 cases aged 0-19 years and 2223 controls. Risk estimates were calculated by unconditional logistic regression, adjusted for age, sex, centre and mother's years of schooling, for all types of CBT combined as well as for four groups defined by histopathology (astroglial tumours, primitive neuroectodermal tumours of the brain, 'other glial' tumours and 'other histological types') and for five age groups (0-1, 0-4, 5-9, 10-14, 15-19 years). Use of anaesthetic 'gas' was associated with an increased risk of CBT (OR = 1.5, 95% CI [1.1, 2.0]), apparent in children aged 0-4 years (OR = 2.4, 95% CI [1.4, 4.1]) and for astroglial tumours (OR = 1.6, 95% CI [1.1, 2.2]) with non-significantly increased relative risks for each of the other histological groups. However, not all centre-specific relative risks were elevated. No other aspect of the index pregnancy, delivery and early neonatal period or of the mother's previous reproductive history was associated with risk for CBT.

Original languageEnglish
Pages (from-to)325-341
Number of pages17
JournalPaediatric and Perinatal Epidemiology
Volume13
Issue number3
DOIs
Publication statusPublished - Jul 1999

Fingerprint

Reproductive History
Environmental Monitoring
Brain Neoplasms
Case-Control Studies
Mothers
Parturition
Pregnancy
Neoplasms
International Agencies
Inhalation Anesthetics
Primitive Neuroectodermal Tumors
Neuroglia
Age Groups
Logistic Models
Brain
Research
Population

ASJC Scopus subject areas

  • Epidemiology
  • Pediatrics, Perinatology, and Child Health

Cite this

SEARCH international case-control study of childhood brain tumours : Role of index pregnancy and birth, and mother's reproductive history. / McCredie, Margaret; Little, Julian; Cotton, Seonaidh; Mueller, Beth; Peris-Bonet, Raphael; Choi, N. W.; Cordier, Sylvaine; Filippini, Graziella; Holly, Elizabeth A.; Modan, Baruch; Arslan, Annie; Preston-Martin, Susan.

In: Paediatric and Perinatal Epidemiology, Vol. 13, No. 3, 07.1999, p. 325-341.

Research output: Contribution to journalArticle

McCredie, M, Little, J, Cotton, S, Mueller, B, Peris-Bonet, R, Choi, NW, Cordier, S, Filippini, G, Holly, EA, Modan, B, Arslan, A & Preston-Martin, S 1999, 'SEARCH international case-control study of childhood brain tumours: Role of index pregnancy and birth, and mother's reproductive history', Paediatric and Perinatal Epidemiology, vol. 13, no. 3, pp. 325-341. https://doi.org/10.1046/j.1365-3016.1999.00195.x
McCredie, Margaret ; Little, Julian ; Cotton, Seonaidh ; Mueller, Beth ; Peris-Bonet, Raphael ; Choi, N. W. ; Cordier, Sylvaine ; Filippini, Graziella ; Holly, Elizabeth A. ; Modan, Baruch ; Arslan, Annie ; Preston-Martin, Susan. / SEARCH international case-control study of childhood brain tumours : Role of index pregnancy and birth, and mother's reproductive history. In: Paediatric and Perinatal Epidemiology. 1999 ; Vol. 13, No. 3. pp. 325-341.
@article{9d56a9b7b6a04e7b8ac4db03b97dd27f,
title = "SEARCH international case-control study of childhood brain tumours: Role of index pregnancy and birth, and mother's reproductive history",
abstract = "A series of co-ordinated population-based case-control studies of childhood brain tumours (CBT) was undertaken under the auspices of the Surveillance of Environmental Aspects Related to Cancer in Humans (SEARCH) programme of the International Agency for Research on Cancer (IARC) to evaluate, inter alia, the risk in relation to characteristics of the index pregnancy and birth, and maternal reproductive history. Subjects comprised 1218 cases aged 0-19 years and 2223 controls. Risk estimates were calculated by unconditional logistic regression, adjusted for age, sex, centre and mother's years of schooling, for all types of CBT combined as well as for four groups defined by histopathology (astroglial tumours, primitive neuroectodermal tumours of the brain, 'other glial' tumours and 'other histological types') and for five age groups (0-1, 0-4, 5-9, 10-14, 15-19 years). Use of anaesthetic 'gas' was associated with an increased risk of CBT (OR = 1.5, 95{\%} CI [1.1, 2.0]), apparent in children aged 0-4 years (OR = 2.4, 95{\%} CI [1.4, 4.1]) and for astroglial tumours (OR = 1.6, 95{\%} CI [1.1, 2.2]) with non-significantly increased relative risks for each of the other histological groups. However, not all centre-specific relative risks were elevated. No other aspect of the index pregnancy, delivery and early neonatal period or of the mother's previous reproductive history was associated with risk for CBT.",
author = "Margaret McCredie and Julian Little and Seonaidh Cotton and Beth Mueller and Raphael Peris-Bonet and Choi, {N. W.} and Sylvaine Cordier and Graziella Filippini and Holly, {Elizabeth A.} and Baruch Modan and Annie Arslan and Susan Preston-Martin",
year = "1999",
month = "7",
doi = "10.1046/j.1365-3016.1999.00195.x",
language = "English",
volume = "13",
pages = "325--341",
journal = "Paediatric and Perinatal Epidemiology",
issn = "0269-5022",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - SEARCH international case-control study of childhood brain tumours

T2 - Role of index pregnancy and birth, and mother's reproductive history

AU - McCredie, Margaret

AU - Little, Julian

AU - Cotton, Seonaidh

AU - Mueller, Beth

AU - Peris-Bonet, Raphael

AU - Choi, N. W.

AU - Cordier, Sylvaine

AU - Filippini, Graziella

AU - Holly, Elizabeth A.

AU - Modan, Baruch

AU - Arslan, Annie

AU - Preston-Martin, Susan

PY - 1999/7

Y1 - 1999/7

N2 - A series of co-ordinated population-based case-control studies of childhood brain tumours (CBT) was undertaken under the auspices of the Surveillance of Environmental Aspects Related to Cancer in Humans (SEARCH) programme of the International Agency for Research on Cancer (IARC) to evaluate, inter alia, the risk in relation to characteristics of the index pregnancy and birth, and maternal reproductive history. Subjects comprised 1218 cases aged 0-19 years and 2223 controls. Risk estimates were calculated by unconditional logistic regression, adjusted for age, sex, centre and mother's years of schooling, for all types of CBT combined as well as for four groups defined by histopathology (astroglial tumours, primitive neuroectodermal tumours of the brain, 'other glial' tumours and 'other histological types') and for five age groups (0-1, 0-4, 5-9, 10-14, 15-19 years). Use of anaesthetic 'gas' was associated with an increased risk of CBT (OR = 1.5, 95% CI [1.1, 2.0]), apparent in children aged 0-4 years (OR = 2.4, 95% CI [1.4, 4.1]) and for astroglial tumours (OR = 1.6, 95% CI [1.1, 2.2]) with non-significantly increased relative risks for each of the other histological groups. However, not all centre-specific relative risks were elevated. No other aspect of the index pregnancy, delivery and early neonatal period or of the mother's previous reproductive history was associated with risk for CBT.

AB - A series of co-ordinated population-based case-control studies of childhood brain tumours (CBT) was undertaken under the auspices of the Surveillance of Environmental Aspects Related to Cancer in Humans (SEARCH) programme of the International Agency for Research on Cancer (IARC) to evaluate, inter alia, the risk in relation to characteristics of the index pregnancy and birth, and maternal reproductive history. Subjects comprised 1218 cases aged 0-19 years and 2223 controls. Risk estimates were calculated by unconditional logistic regression, adjusted for age, sex, centre and mother's years of schooling, for all types of CBT combined as well as for four groups defined by histopathology (astroglial tumours, primitive neuroectodermal tumours of the brain, 'other glial' tumours and 'other histological types') and for five age groups (0-1, 0-4, 5-9, 10-14, 15-19 years). Use of anaesthetic 'gas' was associated with an increased risk of CBT (OR = 1.5, 95% CI [1.1, 2.0]), apparent in children aged 0-4 years (OR = 2.4, 95% CI [1.4, 4.1]) and for astroglial tumours (OR = 1.6, 95% CI [1.1, 2.2]) with non-significantly increased relative risks for each of the other histological groups. However, not all centre-specific relative risks were elevated. No other aspect of the index pregnancy, delivery and early neonatal period or of the mother's previous reproductive history was associated with risk for CBT.

UR - http://www.scopus.com/inward/record.url?scp=13044256398&partnerID=8YFLogxK

U2 - 10.1046/j.1365-3016.1999.00195.x

DO - 10.1046/j.1365-3016.1999.00195.x

M3 - Article

VL - 13

SP - 325

EP - 341

JO - Paediatric and Perinatal Epidemiology

JF - Paediatric and Perinatal Epidemiology

SN - 0269-5022

IS - 3

ER -