Secreted frizzled-related protein 3 (sFRP3) regulates antidepressant responses in mice and humans

M. H. Jang; Y. Kitabatake; E. Kang; H. Jun; M. V. Pletnikov; K. M. Christian; R. Hen; S. Lucae; E. B. Binder; H. Song; G. I. Ming

doi:10.1038/mp.2012.158

Secreted frizzled-related protein 3 (sFRP3) regulates antidepressant responses in mice and humans

M. H. Jang, Y. Kitabatake, E. Kang, H. Jun, M. V. Pletnikov, K. M. Christian, R. Hen, S. Lucae, E. B. Binder^* (Corresponding Author), H. Song^* (Corresponding Author), G. I. Ming^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

24 Citations (Scopus)

Abstract

Major depression, a common mental illness affecting millions of people worldwide, is one of the leading causes of morbidity and has a significant economic cost. Although the mechanisms of action are not well understood, antidepressants, including serotonin-selective reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs), have been used for the treatment of depression, anxiety and other psychiatric disorders.1 Here we identified a Wnt signaling inhibitor, secreted frizzled-related protein (sFRP3), as a molecular target of antidepressant treatments in rodent models, and revealed the significant association of three single-nucleotide polymorphisms (SNPs) in FRZB (the sFRP3 human ortholog) with early antidepressant responses in a clinical cohort.

Original language	English
Pages (from-to)	957-958
Number of pages	2
Journal	Molecular Psychiatry
Volume	18
Issue number	9
Early online date	4 Dec 2012
DOIs	https://doi.org/10.1038/mp.2012.158
Publication status	Published - 1 Sept 2013
Externally published	Yes

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title = "Secreted frizzled-related protein 3 (sFRP3) regulates antidepressant responses in mice and humans",

abstract = "Major depression, a common mental illness affecting millions of people worldwide, is one of the leading causes of morbidity and has a significant economic cost. Although the mechanisms of action are not well understood, antidepressants, including serotonin-selective reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs), have been used for the treatment of depression, anxiety and other psychiatric disorders.1 Here we identified a Wnt signaling inhibitor, secreted frizzled-related protein (sFRP3), as a molecular target of antidepressant treatments in rodent models, and revealed the significant association of three single-nucleotide polymorphisms (SNPs) in FRZB (the sFRP3 human ortholog) with early antidepressant responses in a clinical cohort.",

author = "Jang, {M. H.} and Y. Kitabatake and E. Kang and H. Jun and Pletnikov, {M. V.} and Christian, {K. M.} and R. Hen and S. Lucae and Binder, {E. B.} and H. Song and Ming, {G. I.}",

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doi = "10.1038/mp.2012.158",

language = "English",

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journal = "Molecular Psychiatry",

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T1 - Secreted frizzled-related protein 3 (sFRP3) regulates antidepressant responses in mice and humans

AU - Jang, M. H.

AU - Kitabatake, Y.

AU - Kang, E.

AU - Jun, H.

AU - Pletnikov, M. V.

AU - Christian, K. M.

AU - Hen, R.

AU - Lucae, S.

AU - Binder, E. B.

AU - Song, H.

AU - Ming, G. I.

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Major depression, a common mental illness affecting millions of people worldwide, is one of the leading causes of morbidity and has a significant economic cost. Although the mechanisms of action are not well understood, antidepressants, including serotonin-selective reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs), have been used for the treatment of depression, anxiety and other psychiatric disorders.1 Here we identified a Wnt signaling inhibitor, secreted frizzled-related protein (sFRP3), as a molecular target of antidepressant treatments in rodent models, and revealed the significant association of three single-nucleotide polymorphisms (SNPs) in FRZB (the sFRP3 human ortholog) with early antidepressant responses in a clinical cohort.

AB - Major depression, a common mental illness affecting millions of people worldwide, is one of the leading causes of morbidity and has a significant economic cost. Although the mechanisms of action are not well understood, antidepressants, including serotonin-selective reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs), have been used for the treatment of depression, anxiety and other psychiatric disorders.1 Here we identified a Wnt signaling inhibitor, secreted frizzled-related protein (sFRP3), as a molecular target of antidepressant treatments in rodent models, and revealed the significant association of three single-nucleotide polymorphisms (SNPs) in FRZB (the sFRP3 human ortholog) with early antidepressant responses in a clinical cohort.

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U2 - 10.1038/mp.2012.158

DO - 10.1038/mp.2012.158

M3 - Letter

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AN - SCOPUS:84883170533

SN - 1359-4184

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JO - Molecular Psychiatry

JF - Molecular Psychiatry

IS - 9

ER -

Secreted frizzled-related protein 3 (sFRP3) regulates antidepressant responses in mice and humans

Abstract

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