Seeking a niche

R Martin Roop, Gregory T Robertson, Gail Patricia Ferguson, Liesl E Milford, Malcolm E Winkler, G C Walker

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Long-term residence of the brucellae in the phagosomal compartment of host macrophages is essential to their ability to produce disease in both natural and experimental hosts. Correspondingly, the Brucella spp. appear to be well adapted to resist the multiple environmental stresses they encounter in their intracellular home. This brief review will focus on the contributions of the hfq and bacA gene products to this adaptation. Studies with Brucella hfq mutants suggest that stationary phase physiology is critical for successful long-term residence in host macrophages. Analysis of Brucella bacA mutants, on the other hand, reveal very striking parallels between the strategies employed by the rhizobia to establish and maintain protracted intracellular residence in their plant host and those used by the brucellae during their long-term survival in the phagosomal compartment of host macrophages.
Original languageEnglish
Pages (from-to)349-363
Number of pages15
JournalVeterinary Microbiology
Volume90
Issue number1-4
Publication statusPublished - 20 Dec 2002

Fingerprint

Brucella
niches
macrophages
Macrophages
Host Factor 1 Protein
mutants
Rhizobium
host plants
physiology
genes

Keywords

  • Animals
  • Bacterial Proteins
  • Bacterial Vaccines
  • Brucella
  • Host Factor 1 Protein
  • Intracellular Fluid
  • Macrophages
  • Membrane Proteins
  • Membrane Transport Proteins
  • Mutation
  • Phagosomes

Cite this

Roop, R. M., Robertson, G. T., Ferguson, G. P., Milford, L. E., Winkler, M. E., & Walker, G. C. (2002). Seeking a niche. Veterinary Microbiology, 90(1-4), 349-363.

Seeking a niche. / Roop, R Martin; Robertson, Gregory T; Ferguson, Gail Patricia; Milford, Liesl E; Winkler, Malcolm E; Walker, G C.

In: Veterinary Microbiology, Vol. 90, No. 1-4, 20.12.2002, p. 349-363.

Research output: Contribution to journalArticle

Roop, RM, Robertson, GT, Ferguson, GP, Milford, LE, Winkler, ME & Walker, GC 2002, 'Seeking a niche', Veterinary Microbiology, vol. 90, no. 1-4, pp. 349-363.
Roop RM, Robertson GT, Ferguson GP, Milford LE, Winkler ME, Walker GC. Seeking a niche. Veterinary Microbiology. 2002 Dec 20;90(1-4):349-363.
Roop, R Martin ; Robertson, Gregory T ; Ferguson, Gail Patricia ; Milford, Liesl E ; Winkler, Malcolm E ; Walker, G C. / Seeking a niche. In: Veterinary Microbiology. 2002 ; Vol. 90, No. 1-4. pp. 349-363.
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