Selective Unresponsiveness to Conformational B Cell Epitopes of the Myelin Oligodendrocyte Glycoprotein in H-2b Mice

C. Bourquin, A. Schubart, S. Tobollik, I. Mather, S. Ogg, R. Liblau, Christopher Linington

    Research output: Contribution to journalArticle

    34 Citations (Scopus)

    Abstract

    Autoantibodies directed against conformation-dependent epitopes of the extracellular domain of the myelin oligodendrocyte glycoprotein (MOG(Igd)) play a major role in the immunopathogenesis of demyelination in experimental autoimmune encephalomyelitis. We now demonstrate that one or more genes encoded within the MHC selectively censor the ability of H-2(b) mice to mount this conformation-dependent autoantibody response, while leaving T and B cell responses to linear MOG(Igd) epitopes intact. This novel form of selective B cell unresponsiveness discriminates between pathogenic and nonpathogenic Ab responses to MOG and determines whether or not Ab-dependent effector mechanisms play an important role in the pathogenesis of MOG-induced experimental autoimmune encephalomyelitis in the mouse.

    Original languageEnglish
    Pages (from-to)455-461
    Number of pages6
    JournalThe Journal of Immunology
    Volume171
    Issue number1
    Publication statusPublished - Jul 2003

    Keywords

    • EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
    • MAJOR HISTOCOMPATIBILITY COMPLEX
    • ALLERGIC ENCEPHALOMYELITIS
    • MULTIPLE-SCLEROSIS
    • FINE SPECIFICITY
    • IN-VIVO
    • T-CELLS
    • AUTOANTIBODIES
    • ANTIBODIES
    • PEPTIDE

    Cite this

    Bourquin, C., Schubart, A., Tobollik, S., Mather, I., Ogg, S., Liblau, R., & Linington, C. (2003). Selective Unresponsiveness to Conformational B Cell Epitopes of the Myelin Oligodendrocyte Glycoprotein in H-2b Mice. The Journal of Immunology, 171(1), 455-461.