Selective Unresponsiveness to Conformational B Cell Epitopes of the Myelin Oligodendrocyte Glycoprotein in H-2b Mice

C. Bourquin, A. Schubart, S. Tobollik, I. Mather, S. Ogg, R. Liblau, Christopher Linington

    Research output: Contribution to journalArticle

    34 Citations (Scopus)

    Abstract

    Autoantibodies directed against conformation-dependent epitopes of the extracellular domain of the myelin oligodendrocyte glycoprotein (MOG(Igd)) play a major role in the immunopathogenesis of demyelination in experimental autoimmune encephalomyelitis. We now demonstrate that one or more genes encoded within the MHC selectively censor the ability of H-2(b) mice to mount this conformation-dependent autoantibody response, while leaving T and B cell responses to linear MOG(Igd) epitopes intact. This novel form of selective B cell unresponsiveness discriminates between pathogenic and nonpathogenic Ab responses to MOG and determines whether or not Ab-dependent effector mechanisms play an important role in the pathogenesis of MOG-induced experimental autoimmune encephalomyelitis in the mouse.

    Original languageEnglish
    Pages (from-to)455-461
    Number of pages6
    JournalThe Journal of Immunology
    Volume171
    Issue number1
    Publication statusPublished - Jul 2003

    Keywords

    • EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
    • MAJOR HISTOCOMPATIBILITY COMPLEX
    • ALLERGIC ENCEPHALOMYELITIS
    • MULTIPLE-SCLEROSIS
    • FINE SPECIFICITY
    • IN-VIVO
    • T-CELLS
    • AUTOANTIBODIES
    • ANTIBODIES
    • PEPTIDE

    Cite this

    Bourquin, C., Schubart, A., Tobollik, S., Mather, I., Ogg, S., Liblau, R., & Linington, C. (2003). Selective Unresponsiveness to Conformational B Cell Epitopes of the Myelin Oligodendrocyte Glycoprotein in H-2b Mice. The Journal of Immunology, 171(1), 455-461.

    Selective Unresponsiveness to Conformational B Cell Epitopes of the Myelin Oligodendrocyte Glycoprotein in H-2b Mice. / Bourquin, C.; Schubart, A.; Tobollik, S.; Mather, I.; Ogg, S.; Liblau, R.; Linington, Christopher.

    In: The Journal of Immunology, Vol. 171, No. 1, 07.2003, p. 455-461.

    Research output: Contribution to journalArticle

    Bourquin, C, Schubart, A, Tobollik, S, Mather, I, Ogg, S, Liblau, R & Linington, C 2003, 'Selective Unresponsiveness to Conformational B Cell Epitopes of the Myelin Oligodendrocyte Glycoprotein in H-2b Mice', The Journal of Immunology, vol. 171, no. 1, pp. 455-461.
    Bourquin C, Schubart A, Tobollik S, Mather I, Ogg S, Liblau R et al. Selective Unresponsiveness to Conformational B Cell Epitopes of the Myelin Oligodendrocyte Glycoprotein in H-2b Mice. The Journal of Immunology. 2003 Jul;171(1):455-461.
    Bourquin, C. ; Schubart, A. ; Tobollik, S. ; Mather, I. ; Ogg, S. ; Liblau, R. ; Linington, Christopher. / Selective Unresponsiveness to Conformational B Cell Epitopes of the Myelin Oligodendrocyte Glycoprotein in H-2b Mice. In: The Journal of Immunology. 2003 ; Vol. 171, No. 1. pp. 455-461.
    @article{cdc224654cac4a31ae459baac47d91cf,
    title = "Selective Unresponsiveness to Conformational B Cell Epitopes of the Myelin Oligodendrocyte Glycoprotein in H-2b Mice",
    abstract = "Autoantibodies directed against conformation-dependent epitopes of the extracellular domain of the myelin oligodendrocyte glycoprotein (MOG(Igd)) play a major role in the immunopathogenesis of demyelination in experimental autoimmune encephalomyelitis. We now demonstrate that one or more genes encoded within the MHC selectively censor the ability of H-2(b) mice to mount this conformation-dependent autoantibody response, while leaving T and B cell responses to linear MOG(Igd) epitopes intact. This novel form of selective B cell unresponsiveness discriminates between pathogenic and nonpathogenic Ab responses to MOG and determines whether or not Ab-dependent effector mechanisms play an important role in the pathogenesis of MOG-induced experimental autoimmune encephalomyelitis in the mouse.",
    keywords = "EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, MAJOR HISTOCOMPATIBILITY COMPLEX, ALLERGIC ENCEPHALOMYELITIS, MULTIPLE-SCLEROSIS, FINE SPECIFICITY, IN-VIVO, T-CELLS, AUTOANTIBODIES, ANTIBODIES, PEPTIDE",
    author = "C. Bourquin and A. Schubart and S. Tobollik and I. Mather and S. Ogg and R. Liblau and Christopher Linington",
    year = "2003",
    month = "7",
    language = "English",
    volume = "171",
    pages = "455--461",
    journal = "The Journal of Immunology",
    issn = "0022-1767",
    publisher = "American Association of Immunologists",
    number = "1",

    }

    TY - JOUR

    T1 - Selective Unresponsiveness to Conformational B Cell Epitopes of the Myelin Oligodendrocyte Glycoprotein in H-2b Mice

    AU - Bourquin, C.

    AU - Schubart, A.

    AU - Tobollik, S.

    AU - Mather, I.

    AU - Ogg, S.

    AU - Liblau, R.

    AU - Linington, Christopher

    PY - 2003/7

    Y1 - 2003/7

    N2 - Autoantibodies directed against conformation-dependent epitopes of the extracellular domain of the myelin oligodendrocyte glycoprotein (MOG(Igd)) play a major role in the immunopathogenesis of demyelination in experimental autoimmune encephalomyelitis. We now demonstrate that one or more genes encoded within the MHC selectively censor the ability of H-2(b) mice to mount this conformation-dependent autoantibody response, while leaving T and B cell responses to linear MOG(Igd) epitopes intact. This novel form of selective B cell unresponsiveness discriminates between pathogenic and nonpathogenic Ab responses to MOG and determines whether or not Ab-dependent effector mechanisms play an important role in the pathogenesis of MOG-induced experimental autoimmune encephalomyelitis in the mouse.

    AB - Autoantibodies directed against conformation-dependent epitopes of the extracellular domain of the myelin oligodendrocyte glycoprotein (MOG(Igd)) play a major role in the immunopathogenesis of demyelination in experimental autoimmune encephalomyelitis. We now demonstrate that one or more genes encoded within the MHC selectively censor the ability of H-2(b) mice to mount this conformation-dependent autoantibody response, while leaving T and B cell responses to linear MOG(Igd) epitopes intact. This novel form of selective B cell unresponsiveness discriminates between pathogenic and nonpathogenic Ab responses to MOG and determines whether or not Ab-dependent effector mechanisms play an important role in the pathogenesis of MOG-induced experimental autoimmune encephalomyelitis in the mouse.

    KW - EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

    KW - MAJOR HISTOCOMPATIBILITY COMPLEX

    KW - ALLERGIC ENCEPHALOMYELITIS

    KW - MULTIPLE-SCLEROSIS

    KW - FINE SPECIFICITY

    KW - IN-VIVO

    KW - T-CELLS

    KW - AUTOANTIBODIES

    KW - ANTIBODIES

    KW - PEPTIDE

    M3 - Article

    VL - 171

    SP - 455

    EP - 461

    JO - The Journal of Immunology

    JF - The Journal of Immunology

    SN - 0022-1767

    IS - 1

    ER -