Selenium and iodine deficiencies and selenoprotein function

John Arthur, Fergus Nicol, J H Mitchell, G J Beckett

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12 Citations (Scopus)

Abstract

This paper reviews some recent findings on the interactions between selenium deficiency and iodine deficency. Both micronutrients can control the levels of selenoprotein mRNAs, particularly in the thyroid and brain. When selenium and iodine supplies are limiting the compensatory mechanisms work to minimise adverse effects on thyroid hormone metabolsm and thus neurological development. The mechanisms for regulation of selenoproteins in selenium and iol dine deficiency are however very tissue-specific. For example, unlike the brain and thyroid, brown adipose tissue is unable to retain selenoproteins in selenium and iodine deficiency and is therefore at greater risk from injurious effects of the deficiencies.

Original languageEnglish
Pages (from-to)129-135
Number of pages7
JournalBiomedical and Environmental Sciences
Volume10
Issue number2-3
Publication statusPublished - Sep 1997

Keywords

  • THYROID-HORMONE METABOLISM
  • GENE-EXPRESSION
  • RATS
  • SELENOENZYME
  • EPIDEMIOLOGY
  • DEIODINASES
  • TISSUE

Cite this

Arthur, J., Nicol, F., Mitchell, J. H., & Beckett, G. J. (1997). Selenium and iodine deficiencies and selenoprotein function. Biomedical and Environmental Sciences, 10(2-3), 129-135.