Selenoproteins in human thyroid tissues

P Zagrodzki, Fergus Nicol, John Arthur, M Slowiaczek

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13 Citations (Scopus)

Abstract

The aim of the present work was to clarify whether the activities of selenoenzymes can serve as markers for different tumors or goiters, as classified by histological criteria. The following parameters were determined: 1) selenium content of plasma (Se), 2) activities of the selenoenzymes: plasma glutathione peroxidase (plGSHPx), cytosolic glutathione peroxidase (cGSHPx), type I and type II iodothyronine deiodinases (ID-I, ID-II), thioredoxin reductase (THRR) in human thyroid tissues. The material came from follicular neoplasm, papillary carcinoma, struma nodosa, struma lymphomatosis Hashimoto, other thyroid surgery specimens, and normal tissues. There was no difference in Se nor in plGSHPx between patients and healthy volunteers. No significant differences were found for any parameter in thyroid carcinoma versus normal or goitrous thyroid tissue. In the whole group of thyroid surgery specimens the statistically significant correlations were found between ID-I and ID-II and between THRR and selenoperoxidases. Principal components analysis confirmed the above correlation and moreover revealed correlation between Se and plGSHPx, but did not detect any clear distinction between patients with the different diagnoses.

Original languageEnglish
Pages (from-to)223-227
Number of pages5
JournalBioFactors
Volume14
Issue number1-4
Publication statusPublished - 2001

Keywords

  • selenoenzymes
  • thyroid disorders
  • correlations
  • SELENIUM

Cite this

Zagrodzki, P., Nicol, F., Arthur, J., & Slowiaczek, M. (2001). Selenoproteins in human thyroid tissues. BioFactors, 14(1-4), 223-227.