Self-Powered Wireless Carbohydrate/Oxygen Sensitive Biodevice Based on Radio Signal Transmission

Magnus Falk, Miguel Alcalde, Philip N. Bartlett, Antonio L. De Lacey, Lo Gorton, Cristina Gutierrez-Sanchez, Raoudha Haddad, Jeremy Kilburn, Donal Leech, Roland Ludwig, Edmond Magner, Diana M. Mate, Peter O. Conghaile, Roberto Ortiz, Marcos Pita, Sascha Poller, Tautgirdas Ruzgas, Urszula Salaj-Kosla, Wolfgang Schuhmann, Fredrik Sebelius & 8 others Minling Shao, Leonard Stoica, Cristoph Sygmund, Jonas Tilly, Miguel D. Toscano, Jeevanthi Vivekananthan, Emma Wright, Sergey Shleev*

*Corresponding author for this work

    Research output: Contribution to journalArticle

    44 Citations (Scopus)

    Abstract

    Here for the first time, we detail self-contained (wireless and self-powered) biodevices with wireless signal transmission. Specifically, we demonstrate the operation of self-sustained carbohydrate and oxygen sensitive biodevices, consisting of a wireless electronic unit, radio transmitter and separate sensing bioelectrodes, supplied with electrical energy from a combined multi-enzyme fuel cell generating sufficient current at required voltage to power the electronics. A carbohydrate/oxygen enzymatic fuel cell was assembled by comparing the performance of a range of different bioelectrodes followed by selection of the most suitable, stable combination. Carbohydrates (viz. lactose for the demonstration) and oxygen were also chosen as bioanalytes, being important biomarkers, to demonstrate the operation of the self-contained biosensing device, employing enzyme-modified bioelectrodes to enable the actual sensing. A wireless electronic unit, consisting of a micropotentiostat, an energy harvesting module (voltage amplifier together with a capacitor), and a radio microchip, were designed to enable the biofuel cell to be used as a power supply for managing the sensing devices and for wireless data transmission. The electronic system used required current and voltages greater than 44 mu A and 0.57 V, respectively to operate; which the biofuel cell was capable of providing, when placed in a carbohydrate and oxygen containing buffer. In addition, a USB based receiver and computer software were employed for proof-of concept tests of the developed biodevices. Operation of bench-top prototypes was demonstrated in buffers containing different concentrations of the analytes, showcasing that the variation in response of both carbohydrate and oxygen biosensors could be monitored wirelessly in real-time as analyte concentrations in buffers were changed, using only an enzymatic fuel cell as a power supply.

    Original languageEnglish
    Article number109104
    Pages (from-to)1-9
    Number of pages9
    JournalPloS ONE
    Volume9
    Issue number10
    DOIs
    Publication statusPublished - 13 Oct 2014

    Cite this

    Falk, M., Alcalde, M., Bartlett, P. N., De Lacey, A. L., Gorton, L., Gutierrez-Sanchez, C., ... Shleev, S. (2014). Self-Powered Wireless Carbohydrate/Oxygen Sensitive Biodevice Based on Radio Signal Transmission. PloS ONE, 9(10), 1-9. [109104]. https://doi.org/10.1371/journal.pone.0109104

    Self-Powered Wireless Carbohydrate/Oxygen Sensitive Biodevice Based on Radio Signal Transmission. / Falk, Magnus; Alcalde, Miguel; Bartlett, Philip N.; De Lacey, Antonio L.; Gorton, Lo; Gutierrez-Sanchez, Cristina; Haddad, Raoudha; Kilburn, Jeremy; Leech, Donal; Ludwig, Roland; Magner, Edmond; Mate, Diana M.; Conghaile, Peter O.; Ortiz, Roberto; Pita, Marcos; Poller, Sascha; Ruzgas, Tautgirdas; Salaj-Kosla, Urszula; Schuhmann, Wolfgang; Sebelius, Fredrik; Shao, Minling; Stoica, Leonard; Sygmund, Cristoph; Tilly, Jonas; Toscano, Miguel D.; Vivekananthan, Jeevanthi; Wright, Emma; Shleev, Sergey.

    In: PloS ONE, Vol. 9, No. 10, 109104, 13.10.2014, p. 1-9.

    Research output: Contribution to journalArticle

    Falk, M, Alcalde, M, Bartlett, PN, De Lacey, AL, Gorton, L, Gutierrez-Sanchez, C, Haddad, R, Kilburn, J, Leech, D, Ludwig, R, Magner, E, Mate, DM, Conghaile, PO, Ortiz, R, Pita, M, Poller, S, Ruzgas, T, Salaj-Kosla, U, Schuhmann, W, Sebelius, F, Shao, M, Stoica, L, Sygmund, C, Tilly, J, Toscano, MD, Vivekananthan, J, Wright, E & Shleev, S 2014, 'Self-Powered Wireless Carbohydrate/Oxygen Sensitive Biodevice Based on Radio Signal Transmission', PloS ONE, vol. 9, no. 10, 109104, pp. 1-9. https://doi.org/10.1371/journal.pone.0109104
    Falk M, Alcalde M, Bartlett PN, De Lacey AL, Gorton L, Gutierrez-Sanchez C et al. Self-Powered Wireless Carbohydrate/Oxygen Sensitive Biodevice Based on Radio Signal Transmission. PloS ONE. 2014 Oct 13;9(10):1-9. 109104. https://doi.org/10.1371/journal.pone.0109104
    Falk, Magnus ; Alcalde, Miguel ; Bartlett, Philip N. ; De Lacey, Antonio L. ; Gorton, Lo ; Gutierrez-Sanchez, Cristina ; Haddad, Raoudha ; Kilburn, Jeremy ; Leech, Donal ; Ludwig, Roland ; Magner, Edmond ; Mate, Diana M. ; Conghaile, Peter O. ; Ortiz, Roberto ; Pita, Marcos ; Poller, Sascha ; Ruzgas, Tautgirdas ; Salaj-Kosla, Urszula ; Schuhmann, Wolfgang ; Sebelius, Fredrik ; Shao, Minling ; Stoica, Leonard ; Sygmund, Cristoph ; Tilly, Jonas ; Toscano, Miguel D. ; Vivekananthan, Jeevanthi ; Wright, Emma ; Shleev, Sergey. / Self-Powered Wireless Carbohydrate/Oxygen Sensitive Biodevice Based on Radio Signal Transmission. In: PloS ONE. 2014 ; Vol. 9, No. 10. pp. 1-9.
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    abstract = "Here for the first time, we detail self-contained (wireless and self-powered) biodevices with wireless signal transmission. Specifically, we demonstrate the operation of self-sustained carbohydrate and oxygen sensitive biodevices, consisting of a wireless electronic unit, radio transmitter and separate sensing bioelectrodes, supplied with electrical energy from a combined multi-enzyme fuel cell generating sufficient current at required voltage to power the electronics. A carbohydrate/oxygen enzymatic fuel cell was assembled by comparing the performance of a range of different bioelectrodes followed by selection of the most suitable, stable combination. Carbohydrates (viz. lactose for the demonstration) and oxygen were also chosen as bioanalytes, being important biomarkers, to demonstrate the operation of the self-contained biosensing device, employing enzyme-modified bioelectrodes to enable the actual sensing. A wireless electronic unit, consisting of a micropotentiostat, an energy harvesting module (voltage amplifier together with a capacitor), and a radio microchip, were designed to enable the biofuel cell to be used as a power supply for managing the sensing devices and for wireless data transmission. The electronic system used required current and voltages greater than 44 mu A and 0.57 V, respectively to operate; which the biofuel cell was capable of providing, when placed in a carbohydrate and oxygen containing buffer. In addition, a USB based receiver and computer software were employed for proof-of concept tests of the developed biodevices. Operation of bench-top prototypes was demonstrated in buffers containing different concentrations of the analytes, showcasing that the variation in response of both carbohydrate and oxygen biosensors could be monitored wirelessly in real-time as analyte concentrations in buffers were changed, using only an enzymatic fuel cell as a power supply.",
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    AU - Alcalde, Miguel

    AU - Bartlett, Philip N.

    AU - De Lacey, Antonio L.

    AU - Gorton, Lo

    AU - Gutierrez-Sanchez, Cristina

    AU - Haddad, Raoudha

    AU - Kilburn, Jeremy

    AU - Leech, Donal

    AU - Ludwig, Roland

    AU - Magner, Edmond

    AU - Mate, Diana M.

    AU - Conghaile, Peter O.

    AU - Ortiz, Roberto

    AU - Pita, Marcos

    AU - Poller, Sascha

    AU - Ruzgas, Tautgirdas

    AU - Salaj-Kosla, Urszula

    AU - Schuhmann, Wolfgang

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    AU - Shao, Minling

    AU - Stoica, Leonard

    AU - Sygmund, Cristoph

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    N2 - Here for the first time, we detail self-contained (wireless and self-powered) biodevices with wireless signal transmission. Specifically, we demonstrate the operation of self-sustained carbohydrate and oxygen sensitive biodevices, consisting of a wireless electronic unit, radio transmitter and separate sensing bioelectrodes, supplied with electrical energy from a combined multi-enzyme fuel cell generating sufficient current at required voltage to power the electronics. A carbohydrate/oxygen enzymatic fuel cell was assembled by comparing the performance of a range of different bioelectrodes followed by selection of the most suitable, stable combination. Carbohydrates (viz. lactose for the demonstration) and oxygen were also chosen as bioanalytes, being important biomarkers, to demonstrate the operation of the self-contained biosensing device, employing enzyme-modified bioelectrodes to enable the actual sensing. A wireless electronic unit, consisting of a micropotentiostat, an energy harvesting module (voltage amplifier together with a capacitor), and a radio microchip, were designed to enable the biofuel cell to be used as a power supply for managing the sensing devices and for wireless data transmission. The electronic system used required current and voltages greater than 44 mu A and 0.57 V, respectively to operate; which the biofuel cell was capable of providing, when placed in a carbohydrate and oxygen containing buffer. In addition, a USB based receiver and computer software were employed for proof-of concept tests of the developed biodevices. Operation of bench-top prototypes was demonstrated in buffers containing different concentrations of the analytes, showcasing that the variation in response of both carbohydrate and oxygen biosensors could be monitored wirelessly in real-time as analyte concentrations in buffers were changed, using only an enzymatic fuel cell as a power supply.

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