Self-regulation and the foraging gene (PRKG1) in humans

Andriy A. Struk, Jhotisha Mugon, Andrea Huston, Abigail A. Scholer, Gertraud Stadler, E. Tory Higgins, Marla B. Sokolowski, James Danckert (Corresponding Author)

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Foraging is a goal-directed behaviour that balances the need to explore the environment for resources with the need to exploit those resources. In Drosophila melanogaster distinct phenotypes have been observed in relation to the foraging gene (for), labelled the rover and sitter. Adult rovers explore their environs more extensively than do adult sitters. We explored whether this distinction would be conserved in humans. We made use of a distinction from Regulatory Mode Theory between those who ‘get on with it’–so-called Locomotors, and those who prefer to ensure they ‘do the right thing’, so-called Assessors. In this logic, rovers and Locomotors share similarities in goal pursuit, as do sitters and Assessors. In two samples, we show that genetic variation in PRKG1, the human orthologue of for, is associated with preferential adoption of a specific regulatory mode. Next, participants performed a foraging task to see whether genetic differences associated with distinct regulatory modes would be associated with distinct goal pursuit patterns. Assessors tended to hug the boundary of the foraging environment, much like behaviours seen in Drosophila adult sitters. In a patchy foraging environment, Assessors adopted more cautious search strategies maximising exploitation. These results show that distinct patterns of goal pursuit are associated with particular genotypes of PRKG1, the human orthologue of for.
Original languageEnglish
Pages (from-to)4434-4439
Number of pages6
JournalPNAS
Volume116
Issue number10
Early online date19 Feb 2019
DOIs
Publication statusPublished - 5 Mar 2019

Fingerprint

Genes
Drosophila melanogaster
Drosophila
Genotype
Phenotype
Self-Control
Environ

Keywords

  • foraging gene
  • self-regulation
  • locomotion
  • assessment
  • PRKG1
  • Locomotion
  • Assessment
  • Foraging gene
  • Self-regulation

ASJC Scopus subject areas

  • General

Cite this

Struk, A. A., Mugon, J., Huston, A., Scholer, A. A., Stadler, G., Higgins, E. T., ... Danckert, J. (2019). Self-regulation and the foraging gene (PRKG1) in humans. PNAS, 116(10), 4434-4439. https://doi.org/10.1073/pnas.1809924116

Self-regulation and the foraging gene (PRKG1) in humans. / Struk, Andriy A.; Mugon, Jhotisha; Huston, Andrea; Scholer, Abigail A. ; Stadler, Gertraud; Higgins, E. Tory ; Sokolowski, Marla B.; Danckert, James (Corresponding Author).

In: PNAS, Vol. 116, No. 10, 05.03.2019, p. 4434-4439.

Research output: Contribution to journalArticle

Struk, AA, Mugon, J, Huston, A, Scholer, AA, Stadler, G, Higgins, ET, Sokolowski, MB & Danckert, J 2019, 'Self-regulation and the foraging gene (PRKG1) in humans', PNAS, vol. 116, no. 10, pp. 4434-4439. https://doi.org/10.1073/pnas.1809924116
Struk AA, Mugon J, Huston A, Scholer AA, Stadler G, Higgins ET et al. Self-regulation and the foraging gene (PRKG1) in humans. PNAS. 2019 Mar 5;116(10):4434-4439. https://doi.org/10.1073/pnas.1809924116
Struk, Andriy A. ; Mugon, Jhotisha ; Huston, Andrea ; Scholer, Abigail A. ; Stadler, Gertraud ; Higgins, E. Tory ; Sokolowski, Marla B. ; Danckert, James. / Self-regulation and the foraging gene (PRKG1) in humans. In: PNAS. 2019 ; Vol. 116, No. 10. pp. 4434-4439.
@article{6e305bd2d4464666bcee6fbf7eb7a230,
title = "Self-regulation and the foraging gene (PRKG1) in humans",
abstract = "Foraging is a goal-directed behaviour that balances the need to explore the environment for resources with the need to exploit those resources. In Drosophila melanogaster distinct phenotypes have been observed in relation to the foraging gene (for), labelled the rover and sitter. Adult rovers explore their environs more extensively than do adult sitters. We explored whether this distinction would be conserved in humans. We made use of a distinction from Regulatory Mode Theory between those who ‘get on with it’–so-called Locomotors, and those who prefer to ensure they ‘do the right thing’, so-called Assessors. In this logic, rovers and Locomotors share similarities in goal pursuit, as do sitters and Assessors. In two samples, we show that genetic variation in PRKG1, the human orthologue of for, is associated with preferential adoption of a specific regulatory mode. Next, participants performed a foraging task to see whether genetic differences associated with distinct regulatory modes would be associated with distinct goal pursuit patterns. Assessors tended to hug the boundary of the foraging environment, much like behaviours seen in Drosophila adult sitters. In a patchy foraging environment, Assessors adopted more cautious search strategies maximising exploitation. These results show that distinct patterns of goal pursuit are associated with particular genotypes of PRKG1, the human orthologue of for.",
keywords = "foraging gene, self-regulation, locomotion, assessment, PRKG1, Locomotion, Assessment, Foraging gene, Self-regulation",
author = "Struk, {Andriy A.} and Jhotisha Mugon and Andrea Huston and Scholer, {Abigail A.} and Gertraud Stadler and Higgins, {E. Tory} and Sokolowski, {Marla B.} and James Danckert",
note = "We would like to thank Dr. Sara Mostafavi (University of British Columbia) for directing us to the CMC website regarding gene expression for rs13499 and for statistical advice. This work was supported by NSERC Discovery funds to JD and a Canadian Institute for Advanced Research award to MS.",
year = "2019",
month = "3",
day = "5",
doi = "10.1073/pnas.1809924116",
language = "English",
volume = "116",
pages = "4434--4439",
journal = "PNAS",
issn = "0027-8424",
publisher = "NATL ACAD SCIENCES",
number = "10",

}

TY - JOUR

T1 - Self-regulation and the foraging gene (PRKG1) in humans

AU - Struk, Andriy A.

AU - Mugon, Jhotisha

AU - Huston, Andrea

AU - Scholer, Abigail A.

AU - Stadler, Gertraud

AU - Higgins, E. Tory

AU - Sokolowski, Marla B.

AU - Danckert, James

N1 - We would like to thank Dr. Sara Mostafavi (University of British Columbia) for directing us to the CMC website regarding gene expression for rs13499 and for statistical advice. This work was supported by NSERC Discovery funds to JD and a Canadian Institute for Advanced Research award to MS.

PY - 2019/3/5

Y1 - 2019/3/5

N2 - Foraging is a goal-directed behaviour that balances the need to explore the environment for resources with the need to exploit those resources. In Drosophila melanogaster distinct phenotypes have been observed in relation to the foraging gene (for), labelled the rover and sitter. Adult rovers explore their environs more extensively than do adult sitters. We explored whether this distinction would be conserved in humans. We made use of a distinction from Regulatory Mode Theory between those who ‘get on with it’–so-called Locomotors, and those who prefer to ensure they ‘do the right thing’, so-called Assessors. In this logic, rovers and Locomotors share similarities in goal pursuit, as do sitters and Assessors. In two samples, we show that genetic variation in PRKG1, the human orthologue of for, is associated with preferential adoption of a specific regulatory mode. Next, participants performed a foraging task to see whether genetic differences associated with distinct regulatory modes would be associated with distinct goal pursuit patterns. Assessors tended to hug the boundary of the foraging environment, much like behaviours seen in Drosophila adult sitters. In a patchy foraging environment, Assessors adopted more cautious search strategies maximising exploitation. These results show that distinct patterns of goal pursuit are associated with particular genotypes of PRKG1, the human orthologue of for.

AB - Foraging is a goal-directed behaviour that balances the need to explore the environment for resources with the need to exploit those resources. In Drosophila melanogaster distinct phenotypes have been observed in relation to the foraging gene (for), labelled the rover and sitter. Adult rovers explore their environs more extensively than do adult sitters. We explored whether this distinction would be conserved in humans. We made use of a distinction from Regulatory Mode Theory between those who ‘get on with it’–so-called Locomotors, and those who prefer to ensure they ‘do the right thing’, so-called Assessors. In this logic, rovers and Locomotors share similarities in goal pursuit, as do sitters and Assessors. In two samples, we show that genetic variation in PRKG1, the human orthologue of for, is associated with preferential adoption of a specific regulatory mode. Next, participants performed a foraging task to see whether genetic differences associated with distinct regulatory modes would be associated with distinct goal pursuit patterns. Assessors tended to hug the boundary of the foraging environment, much like behaviours seen in Drosophila adult sitters. In a patchy foraging environment, Assessors adopted more cautious search strategies maximising exploitation. These results show that distinct patterns of goal pursuit are associated with particular genotypes of PRKG1, the human orthologue of for.

KW - foraging gene

KW - self-regulation

KW - locomotion

KW - assessment

KW - PRKG1

KW - Locomotion

KW - Assessment

KW - Foraging gene

KW - Self-regulation

UR - http://www.scopus.com/inward/record.url?scp=85062653567&partnerID=8YFLogxK

U2 - 10.1073/pnas.1809924116

DO - 10.1073/pnas.1809924116

M3 - Article

VL - 116

SP - 4434

EP - 4439

JO - PNAS

JF - PNAS

SN - 0027-8424

IS - 10

ER -