Self-reported pain severity is associated with a history of coronary heart disease

S. Parsons, J. McBeth, G. J. Macfarlane, P. C. Hannaford, D. P. M. Symmons

Research output: Contribution to journalArticle

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Abstract


Background
Previous studies have found an association between chronic pain and cardiovascular (CV) mortality.

Objective
To explore the relationship between the severity of pain and non-fatal CV disease.

Methods
A total of 45,994 adults randomly selected from general practice registers in Manchester and Aberdeen were posted a survey, which included a Chronic Pain Grade questionnaire, pain manikin and questions about lifestyle and medical history. A single component measuring pain severity was extracted using factor analysis. Logistic regression was used to test for an association between quintiles of pain severity and a history of CV disease, adjusting for confounders.

Results
Of the 15,288 responders, 61% (n = 9357) reported pain for ≥1 day in the past month. Compared with the first (lowest) pain severity quintile, the fully adjusted odds ratio for heart attack in the second severity quintile was 1.25 (95% confidence interval 0.68, 2.30); third quintile: 1.65 (0.93, 2.94); fourth quintile: 1.76 (1.00, 3.11) and fifth (highest) quintile 2.47 (1.43, 4.28). Corresponding figures for angina (excluding heart attack) were: 1.79 (0.93, 3.45), 1.91 (1.00, 3.62), 1.03 (0.50, 2.11) and 3.17 (1.71, 5.85).

Conclusion
A history of CV disease is reported more often in those with severe pain than would be expected by chance, even when adjusting for shared risk factors.
Original languageEnglish
Pages (from-to)167-175
Number of pages9
JournalEuropean Journal of Pain
Volume19
Issue number2
Early online date28 May 2014
DOIs
Publication statusPublished - Feb 2015

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Coronary Disease
Pain
Cardiovascular Diseases
Chronic Pain
Myocardial Infarction
Manikins
General Practice
Statistical Factor Analysis
Life Style
Logistic Models
Odds Ratio
Confidence Intervals
Mortality

Cite this

Self-reported pain severity is associated with a history of coronary heart disease. / Parsons, S.; McBeth, J.; Macfarlane, G. J.; Hannaford, P. C.; Symmons, D. P. M.

In: European Journal of Pain, Vol. 19, No. 2, 02.2015, p. 167-175.

Research output: Contribution to journalArticle

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title = "Self-reported pain severity is associated with a history of coronary heart disease",
abstract = "BackgroundPrevious studies have found an association between chronic pain and cardiovascular (CV) mortality.ObjectiveTo explore the relationship between the severity of pain and non-fatal CV disease.MethodsA total of 45,994 adults randomly selected from general practice registers in Manchester and Aberdeen were posted a survey, which included a Chronic Pain Grade questionnaire, pain manikin and questions about lifestyle and medical history. A single component measuring pain severity was extracted using factor analysis. Logistic regression was used to test for an association between quintiles of pain severity and a history of CV disease, adjusting for confounders.ResultsOf the 15,288 responders, 61{\%} (n = 9357) reported pain for ≥1 day in the past month. Compared with the first (lowest) pain severity quintile, the fully adjusted odds ratio for heart attack in the second severity quintile was 1.25 (95{\%} confidence interval 0.68, 2.30); third quintile: 1.65 (0.93, 2.94); fourth quintile: 1.76 (1.00, 3.11) and fifth (highest) quintile 2.47 (1.43, 4.28). Corresponding figures for angina (excluding heart attack) were: 1.79 (0.93, 3.45), 1.91 (1.00, 3.62), 1.03 (0.50, 2.11) and 3.17 (1.71, 5.85).ConclusionA history of CV disease is reported more often in those with severe pain than would be expected by chance, even when adjusting for shared risk factors.",
author = "S. Parsons and J. McBeth and Macfarlane, {G. J.} and Hannaford, {P. C.} and Symmons, {D. P. M.}",
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AU - Parsons, S.

AU - McBeth, J.

AU - Macfarlane, G. J.

AU - Hannaford, P. C.

AU - Symmons, D. P. M.

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N2 - BackgroundPrevious studies have found an association between chronic pain and cardiovascular (CV) mortality.ObjectiveTo explore the relationship between the severity of pain and non-fatal CV disease.MethodsA total of 45,994 adults randomly selected from general practice registers in Manchester and Aberdeen were posted a survey, which included a Chronic Pain Grade questionnaire, pain manikin and questions about lifestyle and medical history. A single component measuring pain severity was extracted using factor analysis. Logistic regression was used to test for an association between quintiles of pain severity and a history of CV disease, adjusting for confounders.ResultsOf the 15,288 responders, 61% (n = 9357) reported pain for ≥1 day in the past month. Compared with the first (lowest) pain severity quintile, the fully adjusted odds ratio for heart attack in the second severity quintile was 1.25 (95% confidence interval 0.68, 2.30); third quintile: 1.65 (0.93, 2.94); fourth quintile: 1.76 (1.00, 3.11) and fifth (highest) quintile 2.47 (1.43, 4.28). Corresponding figures for angina (excluding heart attack) were: 1.79 (0.93, 3.45), 1.91 (1.00, 3.62), 1.03 (0.50, 2.11) and 3.17 (1.71, 5.85).ConclusionA history of CV disease is reported more often in those with severe pain than would be expected by chance, even when adjusting for shared risk factors.

AB - BackgroundPrevious studies have found an association between chronic pain and cardiovascular (CV) mortality.ObjectiveTo explore the relationship between the severity of pain and non-fatal CV disease.MethodsA total of 45,994 adults randomly selected from general practice registers in Manchester and Aberdeen were posted a survey, which included a Chronic Pain Grade questionnaire, pain manikin and questions about lifestyle and medical history. A single component measuring pain severity was extracted using factor analysis. Logistic regression was used to test for an association between quintiles of pain severity and a history of CV disease, adjusting for confounders.ResultsOf the 15,288 responders, 61% (n = 9357) reported pain for ≥1 day in the past month. Compared with the first (lowest) pain severity quintile, the fully adjusted odds ratio for heart attack in the second severity quintile was 1.25 (95% confidence interval 0.68, 2.30); third quintile: 1.65 (0.93, 2.94); fourth quintile: 1.76 (1.00, 3.11) and fifth (highest) quintile 2.47 (1.43, 4.28). Corresponding figures for angina (excluding heart attack) were: 1.79 (0.93, 3.45), 1.91 (1.00, 3.62), 1.03 (0.50, 2.11) and 3.17 (1.71, 5.85).ConclusionA history of CV disease is reported more often in those with severe pain than would be expected by chance, even when adjusting for shared risk factors.

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