Employing an immunocytochemical double-labeling technique, we investigated the co-localization of FOS protein, the expression product of c-fos proto-oncogene induced by orofacial noxious stimulation, and serotonin in the rat brainstem. About 3.2%-25.6% of serotonin-like immunoreactive neurons and 6.2%-46.7% of FOS-like immunoreactive neurons in the raphe nuclei, reticular formation and ventrolateral subdivision of the midbrain periaqueductal gray exhibit FOS-like immunoreactivity and serotonin-like immunoreactivity, respectively. The present results provide further morphological evidence for the involvement of serotoninergic neurons in modulating the transmission of noxious information.
|Number of pages||6|
|Journal||Journal für Hirnforschung|
|Publication status||Published - 1998|
- Brain Stem
- Periaqueductal Gray
- Physical Stimulation
- Proto-Oncogene Proteins c-fos
- Raphe Nuclei
- Rats, Sprague-Dawley
- Reticular Formation
Lang, B., & Li, Y. Q. (1998). Serotoninergic neurons in the brainstem expressing FOS protein after orofacial noxious stimulation: an immunocytochemical double-labeling study. Journal für Hirnforschung, 39(2), 263-8.