Abstract
Employing an immunocytochemical double-labeling technique, we investigated the co-localization of FOS protein, the expression product of c-fos proto-oncogene induced by orofacial noxious stimulation, and serotonin in the rat brainstem. About 3.2%-25.6% of serotonin-like immunoreactive neurons and 6.2%-46.7% of FOS-like immunoreactive neurons in the raphe nuclei, reticular formation and ventrolateral subdivision of the midbrain periaqueductal gray exhibit FOS-like immunoreactivity and serotonin-like immunoreactivity, respectively. The present results provide further morphological evidence for the involvement of serotoninergic neurons in modulating the transmission of noxious information.
Original language | English |
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Pages (from-to) | 263-8 |
Number of pages | 6 |
Journal | Journal für Hirnforschung |
Volume | 39 |
Issue number | 2 |
Publication status | Published - 1998 |
Keywords
- Animals
- Brain Stem
- Face
- Immunohistochemistry
- Male
- Mouth
- Neurons
- Pain
- Periaqueductal Gray
- Physical Stimulation
- Proto-Oncogene Proteins c-fos
- Raphe Nuclei
- Rats
- Rats, Sprague-Dawley
- Reticular Formation
- Serotonin