Serotoninergic neurons in the brainstem expressing FOS protein after orofacial noxious stimulation: an immunocytochemical double-labeling study

B Lang, Y Q Li

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6 Citations (Scopus)


Employing an immunocytochemical double-labeling technique, we investigated the co-localization of FOS protein, the expression product of c-fos proto-oncogene induced by orofacial noxious stimulation, and serotonin in the rat brainstem. About 3.2%-25.6% of serotonin-like immunoreactive neurons and 6.2%-46.7% of FOS-like immunoreactive neurons in the raphe nuclei, reticular formation and ventrolateral subdivision of the midbrain periaqueductal gray exhibit FOS-like immunoreactivity and serotonin-like immunoreactivity, respectively. The present results provide further morphological evidence for the involvement of serotoninergic neurons in modulating the transmission of noxious information.
Original languageEnglish
Pages (from-to)263-8
Number of pages6
JournalJournal für Hirnforschung
Issue number2
Publication statusPublished - 1998



  • Animals
  • Brain Stem
  • Face
  • Immunohistochemistry
  • Male
  • Mouth
  • Neurons
  • Pain
  • Periaqueductal Gray
  • Physical Stimulation
  • Proto-Oncogene Proteins c-fos
  • Raphe Nuclei
  • Rats
  • Rats, Sprague-Dawley
  • Reticular Formation
  • Serotonin

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