Serotoninergic neurons in the brainstem expressing FOS protein after orofacial noxious stimulation: an immunocytochemical double-labeling study

B Lang, Y Q Li

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Employing an immunocytochemical double-labeling technique, we investigated the co-localization of FOS protein, the expression product of c-fos proto-oncogene induced by orofacial noxious stimulation, and serotonin in the rat brainstem. About 3.2%-25.6% of serotonin-like immunoreactive neurons and 6.2%-46.7% of FOS-like immunoreactive neurons in the raphe nuclei, reticular formation and ventrolateral subdivision of the midbrain periaqueductal gray exhibit FOS-like immunoreactivity and serotonin-like immunoreactivity, respectively. The present results provide further morphological evidence for the involvement of serotoninergic neurons in modulating the transmission of noxious information.
Original languageEnglish
Pages (from-to)263-8
Number of pages6
JournalJournal für Hirnforschung
Volume39
Issue number2
Publication statusPublished - 1998

Fingerprint

Serotonergic Neurons
Brain Stem
Serotonin
Proto-Oncogene Proteins c-fos
Neurons
Periaqueductal Gray
Proteins
Raphe Nuclei
Reticular Formation
Mesencephalon

Keywords

  • Animals
  • Brain Stem
  • Face
  • Immunohistochemistry
  • Male
  • Mouth
  • Neurons
  • Pain
  • Periaqueductal Gray
  • Physical Stimulation
  • Proto-Oncogene Proteins c-fos
  • Raphe Nuclei
  • Rats
  • Rats, Sprague-Dawley
  • Reticular Formation
  • Serotonin

Cite this

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title = "Serotoninergic neurons in the brainstem expressing FOS protein after orofacial noxious stimulation: an immunocytochemical double-labeling study",
abstract = "Employing an immunocytochemical double-labeling technique, we investigated the co-localization of FOS protein, the expression product of c-fos proto-oncogene induced by orofacial noxious stimulation, and serotonin in the rat brainstem. About 3.2{\%}-25.6{\%} of serotonin-like immunoreactive neurons and 6.2{\%}-46.7{\%} of FOS-like immunoreactive neurons in the raphe nuclei, reticular formation and ventrolateral subdivision of the midbrain periaqueductal gray exhibit FOS-like immunoreactivity and serotonin-like immunoreactivity, respectively. The present results provide further morphological evidence for the involvement of serotoninergic neurons in modulating the transmission of noxious information.",
keywords = "Animals, Brain Stem, Face, Immunohistochemistry, Male, Mouth, Neurons, Pain, Periaqueductal Gray, Physical Stimulation, Proto-Oncogene Proteins c-fos, Raphe Nuclei, Rats, Rats, Sprague-Dawley, Reticular Formation, Serotonin",
author = "B Lang and Li, {Y Q}",
year = "1998",
language = "English",
volume = "39",
pages = "263--8",
journal = "Journal f{\"u}r Hirnforschung",
issn = "0021-8359",
publisher = "Akademie Verlag GMBH",
number = "2",

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TY - JOUR

T1 - Serotoninergic neurons in the brainstem expressing FOS protein after orofacial noxious stimulation: an immunocytochemical double-labeling study

AU - Lang, B

AU - Li, Y Q

PY - 1998

Y1 - 1998

N2 - Employing an immunocytochemical double-labeling technique, we investigated the co-localization of FOS protein, the expression product of c-fos proto-oncogene induced by orofacial noxious stimulation, and serotonin in the rat brainstem. About 3.2%-25.6% of serotonin-like immunoreactive neurons and 6.2%-46.7% of FOS-like immunoreactive neurons in the raphe nuclei, reticular formation and ventrolateral subdivision of the midbrain periaqueductal gray exhibit FOS-like immunoreactivity and serotonin-like immunoreactivity, respectively. The present results provide further morphological evidence for the involvement of serotoninergic neurons in modulating the transmission of noxious information.

AB - Employing an immunocytochemical double-labeling technique, we investigated the co-localization of FOS protein, the expression product of c-fos proto-oncogene induced by orofacial noxious stimulation, and serotonin in the rat brainstem. About 3.2%-25.6% of serotonin-like immunoreactive neurons and 6.2%-46.7% of FOS-like immunoreactive neurons in the raphe nuclei, reticular formation and ventrolateral subdivision of the midbrain periaqueductal gray exhibit FOS-like immunoreactivity and serotonin-like immunoreactivity, respectively. The present results provide further morphological evidence for the involvement of serotoninergic neurons in modulating the transmission of noxious information.

KW - Animals

KW - Brain Stem

KW - Face

KW - Immunohistochemistry

KW - Male

KW - Mouth

KW - Neurons

KW - Pain

KW - Periaqueductal Gray

KW - Physical Stimulation

KW - Proto-Oncogene Proteins c-fos

KW - Raphe Nuclei

KW - Rats

KW - Rats, Sprague-Dawley

KW - Reticular Formation

KW - Serotonin

M3 - Article

C2 - 10022350

VL - 39

SP - 263

EP - 268

JO - Journal für Hirnforschung

JF - Journal für Hirnforschung

SN - 0021-8359

IS - 2

ER -