Abstract
Background: Lysosomal cathepsin proteases function in a pro-
grammed cell death (LPCD) pathway. Although there is evidence
for the importance of this pathway in cancer cell survival, it has
not been exploited in anti-cancer therapeutics. Hsp70 and ser-
pinB3 can block this pathway and promote cell survival. Further-
more, serpinB3 is associated with lack of response to
chemotherapy. Cathepsin mediated cell death is observed in
response to anthracyclines or taxanes, which are widely utilised
in breast cancer treatment.
grammed cell death (LPCD) pathway. Although there is evidence
for the importance of this pathway in cancer cell survival, it has
not been exploited in anti-cancer therapeutics. Hsp70 and ser-
pinB3 can block this pathway and promote cell survival. Further-
more, serpinB3 is associated with lack of response to
chemotherapy. Cathepsin mediated cell death is observed in
response to anthracyclines or taxanes, which are widely utilised
in breast cancer treatment.
| Original language | English |
|---|---|
| Article number | O-35 |
| Pages (from-to) | 13 |
| Number of pages | 1 |
| Journal | European Journal of Cancer. Supplement |
| Volume | 8 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Sep 2010 |
| Event | 1st British Breast Cancer Research Conference - Nottingham, United Kingdom Duration: 15 Sep 2010 → 17 Sep 2010 |
Keywords
- Breast cancer
- treatment
- biomarkers
- serpinB3
