Serum antibody response against periodontal bacteria and risk of coronary heart disease: systematic review and meta-analysis

Chaitanya Pradeep Joshi, Ranjeet Bapat, William Anderson, Dana Dawson, George Cherukara* (Corresponding Author), Karolin Hijazi* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)
1 Downloads (Pure)


Background: The present systematic review and meta-analysis assessed the strength of a reported association between elevated serum anti-periodontal bacterial antibody responses and an increased risk of coronary heart disease (CHD).
Review: Twenty original studies were identified after systematically searching five databases. The majority (n=11) compared serum anti-Porphyromonas gingivalis (Pg) and/or anti-Aggregatibacter actinomycetemcomitans (Aa) IgG antibody responses between CHD patients and control participants. The strength of the association between serum anti-Pg antibodies and CHD (n=10) and serum anti-Aa antibodies and CHD (n=6) was investigated using a meta-analysis approach separately.
Results: Most studies (61%) reported that the serum IgG antibody responses were elevated in CHD patients than in controls. The meta-analyses showed a significant association between elevated serum IgG antibody responses (anti-Pg and anti-Aa) and CHD risk, with pooled odds ratios of 1.23 (95% CI: 1.09-1.38, p=0.001) and 1.25 (95% CI: 1.04-1.47, p=0.0004), respectively.
Conclusion: A modest increase of CHD risk in individuals with higher serum anti-Pg and anti-Aa IgG antibody responses may support their use as potential biomarkers to detect and monitor at-risk populations. However, observed inconsistencies with the design and interpretation of immunoassays warrants standardisation of the immunoassays assessing antibody responses against periodontal bacteria.
Original languageEnglish
Pages (from-to)1570-1586
Number of pages17
JournalJournal of Journal of Clinical Periodontology
Issue number12
Early online date1 Oct 2021
Publication statusPublished - 31 Dec 2021


  • Myocardial Infarction
  • Periodontitis
  • Atherosclerosis
  • Coronary Artery Disease
  • Antibodies
  • Immunoglobulin G
  • Porphyromonas gingivalis
  • Aggregatibacter actinomycetemcomitans


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