Serum antibody response against periodontal bacteria and risk of coronary heart disease: systematic review and meta-analysis

Chaitanya Pradeep Joshi; Ranjeet  Bapat; William Anderson; Dana Dawson; George Cherukara; Karolin Hijazi

doi:10.1111/jcpe.13550

Serum antibody response against periodontal bacteria and risk of coronary heart disease: systematic review and meta-analysis

Chaitanya Pradeep Joshi, Ranjeet Bapat, William Anderson, Dana Dawson, George Cherukara^* (Corresponding Author), Karolin Hijazi^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

Background: The present systematic review and meta-analysis assessed the strength of a reported association between elevated serum anti-periodontal bacterial antibody responses and an increased risk of coronary heart disease (CHD).
Review: Twenty original studies were identified after systematically searching five databases. The majority (n=11) compared serum anti-Porphyromonas gingivalis (Pg) and/or anti-Aggregatibacter actinomycetemcomitans (Aa) IgG antibody responses between CHD patients and control participants. The strength of the association between serum anti-Pg antibodies and CHD (n=10) and serum anti-Aa antibodies and CHD (n=6) was investigated using a meta-analysis approach separately.
Results: Most studies (61%) reported that the serum IgG antibody responses were elevated in CHD patients than in controls. The meta-analyses showed a significant association between elevated serum IgG antibody responses (anti-Pg and anti-Aa) and CHD risk, with pooled odds ratios of 1.23 (95% CI: 1.09-1.38, p=0.001) and 1.25 (95% CI: 1.04-1.47, p=0.0004), respectively.
Conclusion: A modest increase of CHD risk in individuals with higher serum anti-Pg and anti-Aa IgG antibody responses may support their use as potential biomarkers to detect and monitor at-risk populations. However, observed inconsistencies with the design and interpretation of immunoassays warrants standardisation of the immunoassays assessing antibody responses against periodontal bacteria.

Original language	English
Pages (from-to)	1570-1586
Number of pages	17
Journal	Journal of Journal of Clinical Periodontology
Volume	48
Issue number	12
Early online date	1 Oct 2021
DOIs	https://doi.org/10.1111/jcpe.13550
Publication status	Published - 31 Dec 2021

Keywords

Myocardial Infarction
Periodontitis
Atherosclerosis
Coronary Artery Disease
Antibodies
Immunoglobulin G
Porphyromonas gingivalis
Aggregatibacter actinomycetemcomitans

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@article{7dba3c008704452684b0cc949f22df1a,

title = "Serum antibody response against periodontal bacteria and risk of coronary heart disease: systematic review and meta-analysis",

abstract = "Background: The present systematic review and meta-analysis assessed the strength of a reported association between elevated serum anti-periodontal bacterial antibody responses and an increased risk of coronary heart disease (CHD).Review: Twenty original studies were identified after systematically searching five databases. The majority (n=11) compared serum anti-Porphyromonas gingivalis (Pg) and/or anti-Aggregatibacter actinomycetemcomitans (Aa) IgG antibody responses between CHD patients and control participants. The strength of the association between serum anti-Pg antibodies and CHD (n=10) and serum anti-Aa antibodies and CHD (n=6) was investigated using a meta-analysis approach separately.Results: Most studies (61%) reported that the serum IgG antibody responses were elevated in CHD patients than in controls. The meta-analyses showed a significant association between elevated serum IgG antibody responses (anti-Pg and anti-Aa) and CHD risk, with pooled odds ratios of 1.23 (95% CI: 1.09-1.38, p=0.001) and 1.25 (95% CI: 1.04-1.47, p=0.0004), respectively.Conclusion: A modest increase of CHD risk in individuals with higher serum anti-Pg and anti-Aa IgG antibody responses may support their use as potential biomarkers to detect and monitor at-risk populations. However, observed inconsistencies with the design and interpretation of immunoassays warrants standardisation of the immunoassays assessing antibody responses against periodontal bacteria. ",

keywords = "Myocardial Infarction, Periodontitis, Atherosclerosis, Coronary Artery Disease, Antibodies, Immunoglobulin G, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans",

author = "Joshi, {Chaitanya Pradeep} and Ranjeet Bapat and William Anderson and Dana Dawson and George Cherukara and Karolin Hijazi",

note = "Acknowledgements: The authors would like to thank Dr Neil Scott from the Medical Statistics Team, Division of Applied Health Sciences, the University of Aberdeen for providing statistical support and advice in conducting meta-analyses. Disclosures and funding note: There are no financial disclosures or conflicts of interest to declare for any of the authors. This project received no external funding ",

year = "2021",

month = dec,

day = "31",

doi = "10.1111/jcpe.13550",

language = "English",

volume = "48",

pages = "1570--1586",

journal = "Journal of Journal of Clinical Periodontology",

issn = "0303-6979",

publisher = "Blackwell Munksgaard",

number = "12",

}

TY - JOUR

T1 - Serum antibody response against periodontal bacteria and risk of coronary heart disease

T2 - systematic review and meta-analysis

AU - Joshi, Chaitanya Pradeep

AU - Bapat, Ranjeet

AU - Anderson, William

AU - Dawson, Dana

AU - Cherukara, George

AU - Hijazi, Karolin

N1 - Acknowledgements: The authors would like to thank Dr Neil Scott from the Medical Statistics Team, Division of Applied Health Sciences, the University of Aberdeen for providing statistical support and advice in conducting meta-analyses. Disclosures and funding note: There are no financial disclosures or conflicts of interest to declare for any of the authors. This project received no external funding

PY - 2021/12/31

Y1 - 2021/12/31

N2 - Background: The present systematic review and meta-analysis assessed the strength of a reported association between elevated serum anti-periodontal bacterial antibody responses and an increased risk of coronary heart disease (CHD).Review: Twenty original studies were identified after systematically searching five databases. The majority (n=11) compared serum anti-Porphyromonas gingivalis (Pg) and/or anti-Aggregatibacter actinomycetemcomitans (Aa) IgG antibody responses between CHD patients and control participants. The strength of the association between serum anti-Pg antibodies and CHD (n=10) and serum anti-Aa antibodies and CHD (n=6) was investigated using a meta-analysis approach separately.Results: Most studies (61%) reported that the serum IgG antibody responses were elevated in CHD patients than in controls. The meta-analyses showed a significant association between elevated serum IgG antibody responses (anti-Pg and anti-Aa) and CHD risk, with pooled odds ratios of 1.23 (95% CI: 1.09-1.38, p=0.001) and 1.25 (95% CI: 1.04-1.47, p=0.0004), respectively.Conclusion: A modest increase of CHD risk in individuals with higher serum anti-Pg and anti-Aa IgG antibody responses may support their use as potential biomarkers to detect and monitor at-risk populations. However, observed inconsistencies with the design and interpretation of immunoassays warrants standardisation of the immunoassays assessing antibody responses against periodontal bacteria.

AB - Background: The present systematic review and meta-analysis assessed the strength of a reported association between elevated serum anti-periodontal bacterial antibody responses and an increased risk of coronary heart disease (CHD).Review: Twenty original studies were identified after systematically searching five databases. The majority (n=11) compared serum anti-Porphyromonas gingivalis (Pg) and/or anti-Aggregatibacter actinomycetemcomitans (Aa) IgG antibody responses between CHD patients and control participants. The strength of the association between serum anti-Pg antibodies and CHD (n=10) and serum anti-Aa antibodies and CHD (n=6) was investigated using a meta-analysis approach separately.Results: Most studies (61%) reported that the serum IgG antibody responses were elevated in CHD patients than in controls. The meta-analyses showed a significant association between elevated serum IgG antibody responses (anti-Pg and anti-Aa) and CHD risk, with pooled odds ratios of 1.23 (95% CI: 1.09-1.38, p=0.001) and 1.25 (95% CI: 1.04-1.47, p=0.0004), respectively.Conclusion: A modest increase of CHD risk in individuals with higher serum anti-Pg and anti-Aa IgG antibody responses may support their use as potential biomarkers to detect and monitor at-risk populations. However, observed inconsistencies with the design and interpretation of immunoassays warrants standardisation of the immunoassays assessing antibody responses against periodontal bacteria.

KW - Myocardial Infarction

KW - Periodontitis

KW - Atherosclerosis

KW - Coronary Artery Disease

KW - Antibodies

KW - Immunoglobulin G

KW - Porphyromonas gingivalis

KW - Aggregatibacter actinomycetemcomitans

U2 - 10.1111/jcpe.13550

DO - 10.1111/jcpe.13550

M3 - Review article

C2 - 34545592

VL - 48

SP - 1570

EP - 1586

JO - Journal of Journal of Clinical Periodontology

JF - Journal of Journal of Clinical Periodontology

SN - 0303-6979

IS - 12

ER -

Serum antibody response against periodontal bacteria and risk of coronary heart disease: systematic review and meta-analysis

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Keywords

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