Serum antibody response against periodontal bacteria and risk of coronary heart disease: systematic review and meta-analysis

Chaitanya Pradeep Joshi, Ranjeet Bapat, William Anderson, Dana Dawson, George Cherukara, Karolin Hijazi* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Background: The present systematic review and meta-analysis assessed the strength of a reported association between elevated serum anti-periodontal bacterial antibody responses and an increased risk of coronary heart disease (CHD).
Review: Twenty original studies were identified after systematically searching five databases. The majority (n=11) compared serum anti-Porphyromonas gingivalis (Pg) and/or anti-Aggregatibacter actinomycetemcomitans (Aa) IgG antibody responses between CHD patients and control participants. The strength of the association between serum anti-Pg antibodies and CHD (n=10) and serum anti-Aa antibodies and CHD (n=6) was investigated using a meta-analysis approach separately.
Results: Most studies (61%) reported that the serum IgG antibody responses were elevated in CHD patients than in controls. The meta-analyses showed a significant association between elevated serum IgG antibody responses (anti-Pg and anti-Aa) and CHD risk, with pooled odds ratios of 1.23 (95% CI: 1.09-1.38, p=0.001) and 1.25 (95% CI: 1.04-1.47, p=0.0004), respectively.
Conclusion: A modest increase of CHD risk in individuals with higher serum anti-Pg and anti-Aa IgG antibody responses may support their use as potential biomarkers to detect and monitor at-risk populations. However, observed inconsistencies with the design and interpretation of immunoassays warrants standardisation of the immunoassays assessing antibody responses against periodontal bacteria.
Original languageEnglish
JournalJournal of Journal of Clinical Periodontology
Publication statusAccepted/In press - 2 Sep 2021


  • Myocardial Infarction
  • Periodontitis
  • Atherosclerosis
  • Coronary Artery Disease
  • Antibodies
  • Immunoglobulin G
  • Porphyromonas gingivalis
  • Aggregatibacter actinomycetemcomitans


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